Neurosecretory Cells Expressing the Gene for Common Precursor for Diapause Hormone and Pheromone Biosynthesis-Activating Neuropeptide in the Suboesophageal Ganglion of the Silkworm, Bombyx mori

Sato, Yukihiro; Ikeda, Motoko; Yamashita, Okitsugu

doi:10.1006/gcen.1994.1156

Cited by 86 publications

(38 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The maternal SOG regulates embryonic state by producing diapause hormone (DH), which is a 24-amino acid peptide with a FXPRL motif at the C-terminus (X = G, T, V, S, I). The silkworm DH is encoded by the DH-PBAN gene that is expressed in neurosecretory cells (DHPCs) of the SOG, under the positive control of B. mori Pitx, a bicoid-like homeobox transcription factor that binds a cis-regulatory element in the promoter region of DH-PBAN [90][91][92]. Mammalian Pitx1 encodes an activator of pituitary-specific promoters such as those of genes encoding growth hormone (GH), prolactin (PRL), pro-opiomelanocortin (POMC), luteinizing hormone b-subunit (LHb), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) [93].…”

Section: Embryonic Diapause and Diapause Hormone Signallingmentioning

confidence: 99%

“…In B. mori, the DH precursor peptide can give rise to DH and other four additional FXPRL neuropeptides, the pheromone biosynthesis activating neuropeptide (PBAN) and the suboesophageal ganglion neuropeptides (a-, b-, c-SGNPs) [91,92]. DH, synthesized at the level of SOG of the silkworm, is released via the CC/CA complex in the haemolymph and it signals directly to egg chambers during vitellogenesis to elicit embryonic diapause (Fig.…”

Section: Embryonic Diapause and Diapause Hormone Signallingmentioning

confidence: 99%

See 1 more Smart Citation

The hormonal and circadian basis for insect photoperiodic timing

2011

View full text Add to dashboard Cite

Edited by Martha Merrow and Michael BrunnerKeywords: Insects Photoperiodism Diapause Endocrine axis Circadian clock Clock genes a b s t r a c t Daylength perception in temperate zones is a critical feature of insect life histories, and leads to developmental changes for resisting unfavourable seasons. The role of the neuroendocrine axis in the photoperiodic response of insects is discussed in relation to the key organs and molecules that are involved. We also discuss the controversial issue of the possible involvement of the circadian clock in photoperiodicity. Drosophila melanogaster has a shallow photoperiodic response that leads to reproductive arrest in adults, yet the unrivalled molecular genetic toolkit available for this model insect should allow the systematic molecular and neurobiological dissection of this complex phenotype.

show abstract

Section: Embryonic Diapause and Diapause Hormone Signallingmentioning

confidence: 99%

Section: Embryonic Diapause and Diapause Hormone Signallingmentioning

confidence: 99%

The hormonal and circadian basis for insect photoperiodic timing

2011

View full text Add to dashboard Cite

show abstract

“…DH acts on a G protein-coupled receptor in the developing ovaries of females during pupal-adult development (12,13), and is produced in DH-pheromone-biosynthesis-activating neuropeptide-producing neurosecretory cells (DHPCs) located within the subesophageal ganglion (SG) (14)(15)(16). DH levels in the SG and SG-brain complex are markedly lower in 25DD pupae than in 15DD pupae, although level of mRNA expression is higher in 25DD than in the 15DD pupae at the early to middle stages of pupal-adult development (11,17).…”

mentioning

confidence: 99%

Embryonic thermosensitive TRPA1 determines transgenerational diapause phenotype of the silkworm, Bombyx mori

Sato

Sokabe

Kashio

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

In the bivoltine strain of the silkworm, Bombyx mori, embryonic diapause is induced transgenerationally as a maternal effect. Progeny diapause is determined by the environmental temperature during embryonic development of the mother; however, its molecular mechanisms are largely unknown. Here, we show that the Bombyx TRPA1 ortholog (BmTrpA1) acts as a thermosensitive transient receptor potential (TRP) channel that is activated at temperatures above ∼21°C and affects the induction of diapause in progeny. In addition, we show that embryonic RNAi of BmTrpA1 affects diapause hormone release during pupal-adult development. This study identifying a thermosensitive TRP channel that acts as a molecular switch for a relatively long-term predictive adaptive response by inducing an alternative phenotype to seasonal polyphenism is unique.

show abstract

“…In B. mori, the four neuropeptides, including a hormone inducing embryonic diapause, share a conserved pentapeptide amide at the C-terminal and have substantial pheromonotropic activity (8). Six pairs of somata of neurosecretory cells expressing the gene for the precursor protein are aggregated into three clusters localized at the ventral surface of the anterior, medial, and posterior neuromeres of the suboesophageal ganglion (SOG) (9). Surgical ablation of the anterior and medial clusters of somata at an early pupal stage greatly impaired pheromone production at the adult stage, whereas the same operation on the posterior cluster impaired diapause induction rather than pheromone production, thereby suggesting functional specialization of the three classes of neurosecretory cells (10).…”

mentioning

confidence: 99%

Activity patterns of neurosecretory cells releasing pheromonotropic neuropeptides in the moth Bombyx mori

Ichikawa¹

1998

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Short-and long-term firing patterns of neurosecretory cells releasing pheromonotropic neuropeptides in the silkworm moth Bombyx mori were examined. The cells showed three types of rhythmic changes in firing activity. Bursting activities with an interval of several seconds were synchronized with rhythmic abdominal motions for calling behavior. A slow f luctuation in firing activity over a period of several minutes depended on cyclic alternations of the f low of hemolymph. The electrical activity displayed a diel rhythm that related to light͞dark cycles of the environment and sex pheromone titers in the pheromone gland. In addition to a transient inhibition of firing caused by a tactile or light stimulus, a long-term permanent inhibition was induced by mating with a fertile male. Thus, the insect neurosecretory system is highly coordinated with physiology and behavior in Bombyx mori and is inf luenced by external stimuli.Female moths extrude the pheromone gland and emit sex pheromone to attract males. The calling behavior and sex pheromone production exhibit a diel periodicity with peak pheromone titers occurring during the photophase or scotophase. This diel periodicity of sex pheromone production in many species of moths is under the control of pheromonotropic neuropeptides, such as a pheromone biosynthesisactivating neuropeptide (PBAN) and PBAN-like factors (1, 2). PBANs have been identified from three species of moths (3-5). Analyses of cDNAs encoding PBANs in Bombyx mori and Helicoverpa zea showed that the neuropeptide is generated along with four additional family neuropeptides from a common precursor polyprotein that is translated from a single mRNA (6-8). In B. mori, the four neuropeptides, including a hormone inducing embryonic diapause, share a conserved pentapeptide amide at the C-terminal and have substantial pheromonotropic activity (8). Six pairs of somata of neurosecretory cells expressing the gene for the precursor protein are aggregated into three clusters localized at the ventral surface of the anterior, medial, and posterior neuromeres of the suboesophageal ganglion (SOG) (9). Surgical ablation of the anterior and medial clusters of somata at an early pupal stage greatly impaired pheromone production at the adult stage, whereas the same operation on the posterior cluster impaired diapause induction rather than pheromone production, thereby suggesting functional specialization of the three classes of neurosecretory cells (10). Intracellular dye injection revealed complete structures of individual neurosecretory cells, including a unique axonal pathway and neurohemal terminals (11). Five axons from two anterior and three medial cells project to the corpus cardiacum (CC) after passing through a branch of the maxillary nerve, nervus corporis cardiaci ventralis (NCC-V), that runs beneath the cuticle of the head. Many varicose terminal branches in the CC and associated nerves of the CC indicate that pheromonotropic neuropeptides synthesized in the somata are transferred to neurohemal areas and...

show abstract

Neurosecretory Cells Expressing the Gene for Common Precursor for Diapause Hormone and Pheromone Biosynthesis-Activating Neuropeptide in the Suboesophageal Ganglion of the Silkworm, Bombyx mori

Cited by 86 publications

References 0 publications

The hormonal and circadian basis for insect photoperiodic timing

The hormonal and circadian basis for insect photoperiodic timing

Embryonic thermosensitive TRPA1 determines transgenerational diapause phenotype of the silkworm, Bombyx mori

Activity patterns of neurosecretory cells releasing pheromonotropic neuropeptides in the moth Bombyx mori

Contact Info

Product

Resources

About