Neuropsychological function in obsessive-compulsive disorder: effects of comorbid conditions on task performance

Ayçiçeği, Ayşe; Dinn, Wayne M.; Harris, C. A.; Erkmen, Hüsnü

doi:10.1016/s0924-9338(03)00065-8

Cited by 93 publications

(75 citation statements)

References 46 publications

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“…In addition, Boldrini et al [2005] reported that visuoconstructive deficits seemed specific in OCD and supported the ventral frontostriatal circuit involvement in OCD. According to Aycicegi et al [2003], patients with OCD demonstrated performance deficits on measures of some neuropsychological tests, including visuoconstructional ability, that were consistent with the contention that dysfunction of the orbitofrontal-limbic network underlies OCD. However, Shin et al [2004] reported that using a qualitative scoring system for the ROCF, patients with OCD had impairments only in planning and organization, not in visuoperceptual and visuoconstructional ability during copying.…”

Section: Discussionmentioning

confidence: 57%

Morphometric alterations of anterior superior temporal cortex in obsessive–compulsive disorder

et al. 2006

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The superior temporal gyrus (STG) may be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Moreover, the anterior STG has rich interconnections with the orbitofrontal cortex and the amygdala, and plays a role in visuospatial processing, which is impaired in patients with OCD. This study was designed to examine the morphological abnormalities of the anterior STG and their relationships with visuospatial function and clinical symptom in patients with OCD. We measured gray matter volumes of the anterior STG [rostral STG and planum polare (PP)] by three-dimensional (3D) magnetic resonance imaging in age- and sex-matched groups, which consisted of 22 patients with OCD and 22 normal volunteers. Visuospatial function and clinical symptom were assessed using the Rey-Osterrieth Complex Figure (ROCF) test, the Yale-Brown Obsessive Compulsive Scale, and the Maudsley Obsessive Compulsive Inventory. We found significant volume reductions in bilateral PPs, but there were no significant correlations between brain volumes and the ROCF copy score, immediate or delayed recall score, and clinical symptom in patients with OCD. These results suggest that volume reduction of the anterior STG, especially the PP, may be related to the pathophysiology of OCD, but further research may be needed to explore a relationship of the PP volume change with cognitive impairment observed in patients with OCD.

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Section: Discussionmentioning

confidence: 57%

Morphometric alterations of anterior superior temporal cortex in obsessive–compulsive disorder

et al. 2006

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“…In order to achieve a favorable outcome in the IGT, initially-acquired preference toward the disadvantageous decks should be suppressed, which may rely on reversal learning (Fellows and Farah, 2005;Maia and McClelland, 2004). In OCD, previous studies have suggested impaired reversal learning in line with orbitofrontal dysfunction (Abbruzzese et al, 1997;Aycicegi et al, 2003;Remijnse et al, 2006), but contradictory findings also exist (Chamberlain et al, 2007;Kuelz et al, 2004). Given the critical role of the orbitofrontal cortex in the pathophysiology of OCD, we hypothesized that impaired reversal learning would affect IGT performance in patients with OCD.…”

Section: Discussionmentioning

confidence: 99%

Further evidence of a dissociation between decision-making under ambiguity and decision-making under risk in obsessive–compulsive disorder

Kim¹,

Kang²,

Namkoong³

et al. 2015

Journal of Affective Disorders

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“…Previous studies demonstrated that patients with OCD exhibit extensive cognitive functional dysfunction including the domains of attention, memory, abs tract thinking, and spatial memory 6,7 . Research has shown that OCD patients with depression have obviously decreased executive function 8 . In this study, cognitive functional testing revealed that the performance of patients with OCD for the total number of correct responses, total error number, preservative error number, and number of categories was much worse than that of the control group, which demonstrates that attention and executive function were impaired in patients with OCD.…”

Section: Discussionmentioning

confidence: 99%

Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder

Guo

Zhao

et al. 2014

Arq. Neuro-Psiquiatr.

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Objective: To explore the relationship between regional cerebral blood flow (CBF) and cognitive function in obsessive-compulsive disorder (OCD). Method: Single-photon emission computed tomography (SPECT) was performed for 139 OCD patients and 139 controls, and the radioactivity rate (RAR) was calculated. Cognitive function was assessed by the Wisconsin Card Sorting Test (WCST). Results: The RARs of the prefrontal, anterior temporal, and right occipital lobes were higher in patients than controls. For the WCST, correct and classification numbers were significantly lower, and errors and persistent errors were significantly higher in OCD patients. Right prefrontal lobe RAR was negatively correlated with correct numbers, right anterior temporal lobe RAR was positively correlated with errors, and the RARs of the right prefrontal lobe and left thalamus were positively correlated with persistent errors. Conclusion: OCD patients showed higher CBF in the prefrontal and anterior temporal lobes, suggesting that these areas may be related with cognitive impairment.Keywords: obsessive-compulsive disorder, regional cerebral blood flow, cognitive function. ResumoObjetivo: Estudar a relação entre a perfusão sanguínea regional cerebral e as funções cognitivas em pacientes com transtorno obsessivo compulsivo (TOC). Método: Foram estudados 139 pacientes com TOC e 139 controles. As imagens do fluxo sanguíneo cerebral foram feitas por single photon emission computed tomography e o radioactivity rate (RAR) foi calculado usando como referência a radioatividade do córtex cerebelar. As funções cognitivas foram avaliadas através do Wisconsin Card Sorting Test (WCST). Resultados: O RAR do lobo pré-frontal, do lobo temporal anterior e do lobo occipital direito foram mais elevados nos pacientes do que nos controles (P<0.05). Quanto ao WCST, os escores de números corretos (P<0.01) e de classificação (P<0.05) foram menores no grupo TOC do que nos controles; entretanto, os escores de erros e de erros persistentes nos controles foram mais elevados do que nos pacientes (P<0.01). O RAR do lobo pré-frontal direito estava relacionado de modo negativo com os números corretos; o RAR do lobo temporal anterior apresentava correlação positiva com os erros; o RAR do lobo pré-frontal direito e do tálamo esquerdo apresentavam correlação positiva com erros persistentes. Conclusão: Pacientes com TOC apresentaram perfusão sanguínea cerebral mais intensa no lobo pré-frontal e no lobo temporal anterior. O lobo pré-frontal direito, o lobo temporal e o tálamo esquerdo podem estar relacionados com alterações cognitivas.Palavras-chave: transtorno obsessivo-compulsivo, fluxo sanguíneo regional cerebral, função cognitiva.Obsessive-compulsive disorder (OCD) is an intractable psychiatric condition. OCD morbidity is 2-3%, which severely affects patients' quality of life 1 . In order to investigate the biological basis underlying changes in cerebral function in patients with OCD, we assessed cerebral blood flow (CBF) with single-photon emission computed tomograph...

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Neuropsychological function in obsessive-compulsive disorder: effects of comorbid conditions on task performance

Abstract: Findings are consistent with the contention that dysfunction of an orbitofrontal-limbic network underlies OCD.

Cited by 93 publications

References 46 publications

Morphometric alterations of anterior superior temporal cortex in obsessive–compulsive disorder

Morphometric alterations of anterior superior temporal cortex in obsessive–compulsive disorder

Further evidence of a dissociation between decision-making under ambiguity and decision-making under risk in obsessive–compulsive disorder

Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder

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