Neuropsychological and psychiatric abnormalities in myalgic encephalomyelitis: A preliminary report

Riccio, Massimo; Thompson, Christopher; Wilson, Barbara A.; Morgan, David; Lant, A. F.

doi:10.1111/j.2044-8260.1992.tb00975.x

Cited by 62 publications

(26 citation statements)

References 13 publications

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“…Smith (1991) found that CFS patients were slower at psychomotor tasks, had problems with selective and sustained attention, certain memory impairments and also increased sensitivity to visually disturbing patterns. In contrast to this, Riccio, Thompson, Wilson, Morgan & Lant (1992) reported that their CFS patients were only impaired on the ability to recall information from a story and on a paired associate learning task. The main aim of the present study was to extend these preliminary studies using a larger, clearly defined group of CFS patients.…”

mentioning

confidence: 84%

Behavioural problems associated with the chronic fatigue syndrome

Smith

Behan

Bell

et al. 1993

British J of Psychology

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Disturbances of memory, concentration and motor function are often reported by patients with the chronic fatigue syndrome (CFS). The present study objectively evaluated these behavioural problems using a computerized test battery measuring memory, attention and motor skills. Fifty-seven CFS patients were compared with 19 matched controls and all subjects completed the performance test battery and filled in questionnaires measuring psychopathology and mood. The patients reported significantly higher levels of depression, anxiety, physical symptoms and cognitive failures than the controls. Similarly, they reported more negative affect at the time of testing. The patients were slower on psychomotor tasks, showed increased visual sensitivity and impaired attention. Digit span and free recall were not impaired but retrieval from semantic memory and logical reasoning were slower. None of the performance differences between patients and controls could be attributed to differences in psychopathology. These results agree with recent findings from other laboratories, and it is now time to consider the nature of the neurological dysfunction underlying these effects.

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confidence: 84%

Behavioural problems associated with the chronic fatigue syndrome

Smith

Behan

Bell

et al. 1993

British J of Psychology

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“…For example, Riccio et al (1992) compared the performance of nine CFS patients to nine control subjects matched for age, sex, and premorbid intelligence. They employed a series of neuropsychological tests measuring intelligence, memory, problem solving, and psychomotor speed.…”

Section: Studies Employing Control Groupsmentioning

confidence: 99%

Neurocognitive functioning in chronic fatigue syndrome

DiPino

Kane

1996

Neuropsychol Rev

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Although substantial research has been conducted on chronic fatigue syndrome (CFS) over the past decade, the syndrome remains poorly understood. The most recent case definition describes CFS as being characterized both by disabling fatigue and by subjective reports of difficulty with concentration and "short-term" memory. However, research into the neurocognitive and psychological functioning of individuals with CFS has provided mixed objective results. The current paper reviews studies that have examined the neurocognitive and/or psychological functioning of individuals with CFS. Changes in research design and instruments employed to study individuals with CFS are suggested.

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“…For example, patients with CFS report an increased perception of muscular effort despite submaximal performance on exercise testing (Stokes et al 1988 ;Riley et al 1990), but the same may be true in depression, where impairment of motor function extends even to maximal voluntary hand grip (Cohen et al 1982 ;Moffoot et al 1994). Subjective reports of cognitive impairment in CFS are supported by objective evidence for slowed reaction time and poor memory or attention (Millon et al 1989 ;Altay et al 1990 ;Riccio et al 1992 ;Grafman et al 1993 ;MacDonald et al 1993 ;Ray et al 1993 ;Sandman et al 1993 ;Schmaling et al 1994 ;Cope et al 1995 ;DeLuca et al 1995 ;Joyce et al 1996 ;Marcel et al 1996 ;Marshall et al 1997 ;Vollmer-Conna et al 1997 ;Wearden & Appleby, 1997 ;Johnson et al 1998). A comparison with depression suggests a similar pattern of impairments (e.g.…”

Section: Introductionmentioning

confidence: 99%

The difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness

Lawrie

MacHale²,

Cavanagh³

et al. 2000

Psychol. Med.

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Background. Chronic fatigue syndrome (CFS) and major depressive disorder (MDD) share many symptoms and aetiological factors but may have different neurobiological underpinnings. We wished to determine the profile of the biological variables disturbed in CFS and MDD, and identify any critical factors that differentiate the disorders. Methods. Thirty patients with CFS, 20 with MDD and 15 healthy controls -matched group-wise for age and sex -were recruited. Subjects were given a detailed battery of motor and cognitive tests, including measures of psychomotor speed, memory and maximal voluntary muscle contraction in both the morning and evening that were balanced to avoid order effects. Results. CFS patients generally performed worse on cognitive tests than healthy controls, but better than patients with MDD. Both patient groups had markedly impaired motor function compared with healthy controls. MDD subjects showed a significantly greater diurnal improvement in maximal voluntary contraction than healthy controls. Conclusions. Patients with CFS and MDD show similarly substantial motor impairment, but cognitive deficits are generally more marked in MDD. Diurnal changes in some functions in MDD may differentiate the disorder from CFS.

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Neuropsychological and psychiatric abnormalities in myalgic encephalomyelitis: A preliminary report

Cited by 62 publications

References 13 publications

Behavioural problems associated with the chronic fatigue syndrome

Behavioural problems associated with the chronic fatigue syndrome

Neurocognitive functioning in chronic fatigue syndrome

The difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness

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