Neuropsychiatric symptoms and past manganese exposure in a ferro-alloy plant

Bouchard, Maryse F.; Mergler, Donna; Baldwin, Mary; Panisset, Michel; Roels, Harry

doi:10.1016/j.neuro.2006.08.002

Cited by 60 publications

(31 citation statements)

References 38 publications

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“…21 Higher means were reported in alloy-production workers (12 mg/l). 26,29,30 A receiver operating characteristic analysis determined 10 mg/l as 95 th % percentile in a group of unexposed South African workers in comparison to smelters. 26 Every other welder in our study was above that value.…”

Section: Discussionmentioning

confidence: 99%

Levels and predictors of airborne and internal exposure to manganese and iron among welders

Pesch

Weiß

Kendzia

et al. 2012

J Expo Sci Environ Epidemiol

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ning 11 and The Weldox GroupWe investigated airborne and internal exposure to manganese (Mn) and iron (Fe) among welders. Personal sampling of welding fumes was carried out in 241 welders during a shift. Metals were determined by inductively coupled plasma mass spectrometry. Mn in blood (MnB) was analyzed by graphite furnace atom absorption spectrometry. Determinants of exposure levels were estimated with multiple regression models. Respirable Mn was measured with a median of 62 (inter-quartile range (IQR) 8.4 --320) mg/m 3 and correlated with Fe (r ¼ 0.92, 95% CI 0.90 --0.94). Inhalable Mn was measured with similar concentrations (IQR 10 --340 mg/m 3 ). About 70% of the variance of Mn and Fe could be explained, mainly by the welding process. Ventilation decreased exposure to Fe and Mn significantly. Median concentrations of MnB and serum ferritin (SF) were 10.30 mg/l (IQR 8.33 --13.15 mg/l) and 131 mg/l (IQR 76 --240 mg/l), respectively. Few welders were presented with low iron stores, and MnB and SF were not correlated (r ¼ 0.07, 95% CI À0.05 to 0.20). Regression models revealed a significant association of the parent metal with MnB and SF, but a low fraction of variance was explained by exposure-related factors. Mn is mainly respirable in welding fumes. Airborne Mn and Fe influenced MnB and SF, respectively, in welders. This indicates an effect on the biological regulation of both metals. Mn and Fe were strongly correlated, whereas MnB and SF were not, likely due to higher iron stores among welders.

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Section: Discussionmentioning

confidence: 99%

Levels and predictors of airborne and internal exposure to manganese and iron among welders

Pesch

Weiß

Kendzia

et al. 2012

J Expo Sci Environ Epidemiol

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“…A psychosis (locura manganica) marked by aggressivity was reported among workers exposed via dust to very high Mn levels. Long-term changes in neuromotor, cognitive, and mood domains have been described in exposed occupational groups (Bouchard et al 2007;Roels et al 1985). Manganism can progress even after cessation of exposure and has long been considered irreversible (Huang et al 1993).…”

Section: Clinical Aspectsmentioning

confidence: 99%

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

et al. 2009

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Abstract:The purpose of this review is to highlight recent advances in the neuropathology associated with Mn exposures. We commence with a discussion on occupational manganism and clinical aspects of the disorder. This is followed by novel considerations on Mn transport (see also chapter by Yokel, this volume), advancing new hypotheses on the involvement of several transporters in Mn entry into the brain. This is followed by a brief description of the effects of Mn on neurotransmitter systems that are putative modulators of dopamine (DA) biology (the primary target of Mn neurotoxicity), as well as its effects on mitochondrial dysfunction and disruption of cellular energy metabolism. Next, we discuss inflammatory activation of glia in neuronal injury and how disruption of synaptic transmission and glial-neuronal communication may serve as underlying mechanisms of Mn-induced neurodegeneration commensurate with the cross-talk between glia and neurons. We conclude with a discussion on therapeutic aspects of Mn exposure. Emphasis is directed at treatment modalities and the utility of chelators in attenuating the neurodegenerative sequelae of exposure to Mn. For additional reading on several topics inherent to this review as well as others, the reader may wish to consult Aschner and Dorman (Toxicological Review 25:147-154, 2007) and Bowman et al. (Metals and neurodegeneration, 2009).

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“…and flight of ideas, in addition to the Parkinson's-like effects related to motor dysfunction (Bowler et al, 2006;Bouchard et al, 2007;Guilarte et al, 2008a;Guilarte, 2010).…”

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confidence: 99%