Neuropsychiatric Assessment of Patients With Hyperkinetic and Hypokinetic Movement Disorders

Abstract

We found that patients with HD manifested predominantly hyperactive behaviors, while those with PSP manifested hypoactive behaviors. Based on our findings and the anatomical lesions known to occur in these disorders, we suggest that the hyperactive behaviors in HD are secondary to an excitatory subcortical output through the medial and orbitofrontal cortical circuits, while in PSP the hypoactive behaviors are secondary to hypostimulation.

Determinants of irritability in Huntington's disease

“…The study shows that irritability in HD has a significant association with anxiety and depression. This is consistent with a previous study (15) which showed correlation between NPI domains of irritability anxiety and depression in HD subjects. However, there was variation in the level and significance of association based on the nature of irritability (self-rated or carer-rated), type of anxiety (state or trait) and depression.…”

Determinants of irritability in Huntington's disease

“…The study shows that irritability in HD has a significant association with anxiety and depression. This is consistent with a previous study (15) which showed correlation between NPI domains of irritability anxiety and depression in HD subjects. However, there was variation in the level and significance of association based on the nature of irritability (self-rated or carer-rated), type of anxiety (state or trait) and depression.…”

Neuropsychiatric aspects of Huntington's disease

“…Specifically, the MMSE, total DRS, chorea severity, and disease duration were not significantly correlated with any neuropsychiatric symptom. These findings are consistent with other research21 and indicate that behavioural aspects of basal ganglia diseases are often independent of cognitive and motor symptoms, at least early in the disease.…”

Neuropsychiatric differences between Parkinson's disease with dementia and Alzheimer's disease

“…The results in this study show that neuropsychiatric symptoms are common and severe in PD patients with dementia. A large proportion of PDD patients, 85%, showed at least one psychiatric symptom, almost as high as that observed in AD, and similar to that observed in other basal ganglia disorders (Litvan et al, 1998a). Among those patients who exhibited the symptom, higher (apathy and aberrant motor behavior) or equal severity was found in PDD than AD patients.…”

Determinants of irritability in Huntington's disease

“…The study shows that irritability in HD has a significant association with anxiety and depression. This is consistent with a previous study (15) which showed correlation between NPI domains of irritability anxiety and depression in HD subjects. However, there was variation in the level and significance of association based on the nature of irritability (self-rated or carer-rated), type of anxiety (state or trait) and depression.…”

Neuropsychiatric aspects of Huntington's disease

“…Specifically, the MMSE, total DRS, chorea severity, and disease duration were not significantly correlated with any neuropsychiatric symptom. These findings are consistent with other research21 and indicate that behavioural aspects of basal ganglia diseases are often independent of cognitive and motor symptoms, at least early in the disease.…”

Neuropsychiatric differences between Parkinson's disease with dementia and Alzheimer's disease

“…The results in this study show that neuropsychiatric symptoms are common and severe in PD patients with dementia. A large proportion of PDD patients, 85%, showed at least one psychiatric symptom, almost as high as that observed in AD, and similar to that observed in other basal ganglia disorders (Litvan et al, 1998a). Among those patients who exhibited the symptom, higher (apathy and aberrant motor behavior) or equal severity was found in PDD than AD patients.…”

Determinants of irritability in Huntington's disease

“…The study shows that irritability in HD has a significant association with anxiety and depression. This is consistent with a previous study (15) which showed correlation between NPI domains of irritability anxiety and depression in HD subjects. However, there was variation in the level and significance of association based on the nature of irritability (self-rated or carer-rated), type of anxiety (state or trait) and depression.…”

Neuropsychiatric aspects of Huntington's disease

“…Specifically, the MMSE, total DRS, chorea severity, and disease duration were not significantly correlated with any neuropsychiatric symptom. These findings are consistent with other research21 and indicate that behavioural aspects of basal ganglia diseases are often independent of cognitive and motor symptoms, at least early in the disease.…”

Neuropsychiatric differences between Parkinson's disease with dementia and Alzheimer's disease

“…The results in this study show that neuropsychiatric symptoms are common and severe in PD patients with dementia. A large proportion of PDD patients, 85%, showed at least one psychiatric symptom, almost as high as that observed in AD, and similar to that observed in other basal ganglia disorders (Litvan et al, 1998a). Among those patients who exhibited the symptom, higher (apathy and aberrant motor behavior) or equal severity was found in PDD than AD patients.…”