Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats

Peeyush, Kumar T.; Gangadharan, Gireesh; Mathew, Joseph; Paulose, C S

doi:10.1016/j.lfs.2009.09.012

Cited by 51 publications

(31 citation statements)

References 71 publications

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“…Previous reports show that diabetes mellitus specifically impair the memory function in experimental animals with strong involvement of the hippocampus and cerebral cortex [25]. Earlier works from our laboratory on neurochemical changes induced by diabetes showed cholinergic deficit in brain regions like cerebral cortex, cerebellum [26,27] causing cognitive dysfunction in diabetic rats. Present study analysed brainstem Cholinergic, Insulin, Vitamin D receptors and GLUT 3 gene expression is affected by diabetes and Vitamin D supplementation could modulate the brainstem receptors.…”

Section: Discussionmentioning

confidence: 92%

Expression of Cholinergic, Insulin, Vitamin D Receptors and GLUT 3 in the Brainstem of Streptozotocin Induced Diabetic Rats: Effect of Treatment with Vitamin D3

et al. 2011

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Complications arising from diabetes mellitus include cognitive deficits, neurophysiological and structural changes in the brain. The current study investigated the expression of cholinergic, insulin, Vitamin D receptor and GLUT 3 in the brainstem of streptozotocin-induced diabetic rats. Radioreceptor binding assays and gene expression were done in the brainstem of male Wistar rats. Our results showed that B(max) of total muscarinic, muscarinic M3 receptors was increased and muscarinic M1 receptor was decreased in diabetic rats compared to control. A significant increase in gene expression of muscarinic M3, α7 nicotinic acetylcholine, insulin, Vitamin D₃ receptors, acetylcholine esterase, choline acetyl transferase and GLUT 3 were observed in the brainstem of diabetic rats. Immunohistochemistry studies of muscarinic M1, M3 and α7 nicotinic acetylcholine receptors confirmed the gene expression at protein level. Vitamin D₃ and insulin treatment reversed diabetes-induced alterations to near control. This study provides an evidence that diabetes can alter the expression of cholinergic, insulin, Vitamin D receptors and GLUT 3 in brainstem. We found that Vitamin D₃ treatment could modulate the Vitamin D receptors and plays a pivotal role in maintaining the glucose transport and expressional level of cholinergic receptors in the brainstem of diabetic rats. Thus, our results suggest a therapeutic role of Vitamin D₃ in managing neurological disorders associated with diabetes.

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Section: Discussionmentioning

confidence: 92%

Expression of Cholinergic, Insulin, Vitamin D Receptors and GLUT 3 in the Brainstem of Streptozotocin Induced Diabetic Rats: Effect of Treatment with Vitamin D3

et al. 2011

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“…The oral dose of curcumin 60 mg/kg body weight for 14 days (20) and 90 mg/kg body weight for 15 days in hyperglycaemic rats were studied and they showed antidiabetic activity (21). In another study which was conducted in 2011, a dose of 150 mg/kg body weight for 49 days in hyperglycaemic rats prevented body weight loss and decreased blood glucose level (22).…”

Section: Curcuma Longa (Turmeric)mentioning

confidence: 99%

Recent Progress for the Utilization of Curcuma longa, Piper nigrum and Phoenix dactylifera Seeds against Type 2 Diabetes

Khaliq¹,

Sarfraz²,

Ashraf³

2016

West Indian Med J

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“…Curcumin has been used as an antioxidant, antiseptic, anti-inflammatory, antibacterial and antitumor agent and has been used against various disorders such as arthritis, cardiovascular diseases, lung fibrosis, gall stone formation, cardiotoxicity, diabetes, wound healing, AD and many more (Aggarwal 2006, Sharma et al, 2006. Recent studies have also shown curcumin to be protective against cancer (Duvoix et al, 2005), diabetes (Cheng et al, 2009, Peeyush et al, 2009) and for the reduction of blood cholesterol (Alwi et al, 2008, Ejaz et al, 2009, Jang et al, 2008. Curcumin protects against ischemia induced elevation in malondialdehyde (MDA) and lactate dehydrogenase (LDH) release in animal models (Dikshit et al, 1995).…”

Section: Intracellular Targetsmentioning

confidence: 99%

Therapeutic Potential of Polyphenols in Parkinson’s Disease

Mythri¹,

Harish²,

Raghunath³

et al. 2011

Towards New Therapies for Parkinson's Disease

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Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats

Cited by 51 publications

References 71 publications

Expression of Cholinergic, Insulin, Vitamin D Receptors and GLUT 3 in the Brainstem of Streptozotocin Induced Diabetic Rats: Effect of Treatment with Vitamin D3

Expression of Cholinergic, Insulin, Vitamin D Receptors and GLUT 3 in the Brainstem of Streptozotocin Induced Diabetic Rats: Effect of Treatment with Vitamin D3

Recent Progress for the Utilization of Curcuma longa, Piper nigrum and Phoenix dactylifera Seeds against Type 2 Diabetes

Therapeutic Potential of Polyphenols in Parkinson’s Disease

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