Neuroprotective factors and incident hearing impairment in the epidemiology of hearing loss study

Paulsen, Adam; Cruickshanks, Karen J.; Pinto, Alex; Schubert, Carla R.; Dalton, Dayna S.; Fischer, Mary; Klein, Barbara E.K.; Klein, Ronald; Tsai, Michael Y.; Tweed, Ted S.

doi:10.1002/lary.27847

Cited by 4 publications

(1 citation statement)

References 32 publications

(101 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, cumulative incidences of 37.2% at 10-year, 54.9% at 16-year and 75% at 20-year follow-up times have been reported in the EHLS (Cruickshanks et al, 2010;Paulsen et al, 2019;Schubert et al, 2018).…”

Section: Introductionmentioning

confidence: 98%

Prevalence and incidence of hearing impairment among adults: a 13-year follow-up study

Lohi

Ohtonen

Sorri

et al. 2021

International Journal of Audiology

View full text Add to dashboard Cite

Objective: To investigate the prevalence and incidence of hearing impairment (HI) in a longitudinal setting among adults. Design: An unscreened, population-based epidemiological 13-year follow-up study. Study sample: 850 randomly sampled 54 to 66-year-old baseline participants, of whom 559 participated in the follow-up study at the age of 68 to 79 years. A questionnaire-based interview, an otological examination and pure-tone audiometry were performed. Results: The overall prevalence of HI was 70.3%, defined by better ear hearing level (BEHL) ≥20 dB in the 0.5-4 kHz frequency range. The prevalence was higher among men (78.6%) than among women (63.7%). The overall incidence rate for HI was 45.8 per 1000 person years and the 13-year cumulative incidence was 60.9%. The incidence was higher among men and older participants. Conclusion: HI is highly prevalent and incident among older adults in Northern Finland.

show abstract

Section: Introductionmentioning

confidence: 98%

Prevalence and incidence of hearing impairment among adults: a 13-year follow-up study

Lohi

Ohtonen

Sorri

et al. 2021

International Journal of Audiology

View full text Add to dashboard Cite

show abstract

Establishing multifactorial risk factors for adult-onset hearing loss: A systematic review with topic modelling and synthesis of epidemiological evidence

Tran,

Tang,

et al. 2024

Preventive Medicine

View full text Add to dashboard Cite

Micro Injection Molding of Drug-Loaded Round Window Niche Implants for an Animal Model Using 3D-Printed Molds

Mau

Eickner²,

Jüttner

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

A novel approach for the long-term medical treatment of the inner ear is the diffusion of drugs through the round window membrane from a patient-individualized, drug-eluting implant, which is inserted in the middle ear. In this study, drug-loaded (10 wt% Dexamethasone) guinea pig round window niche implants (GP-RNIs, ~1.30 mm × 0.95 mm × 0.60 mm) were manufactured with high precision via micro injection molding (µIM, Tmold = 160 °C, crosslinking time of 120 s). Each implant has a handle (~3.00 mm × 1.00 mm × 0.30 mm) that can be used to hold the implant. A medical-grade silicone elastomer was used as implant material. Molds for µIM were 3D printed from a commercially available resin (TG = 84 °C) via a high-resolution DLP process (xy resolution of 32 µm, z resolution of 10 µm, 3D printing time of about 6 h). Drug release, biocompatibility, and bioefficacy of the GP-RNIs were investigated in vitro. GP-RNIs could be successfully produced. The wear of the molds due to thermal stress was observed. However, the molds are suitable for single use in the µIM process. About 10% of the drug load (8.2 ± 0.6 µg) was released after 6 weeks (medium: isotonic saline). The implants showed high biocompatibility over 28 days (lowest cell viability ~80%). Moreover, we found anti-inflammatory effects over 28 days in a TNF-α-reduction test. These results are promising for the development of long-term drug-releasing implants for human inner ear therapy.

show abstract

Neuroprotective factors and incident hearing impairment in the epidemiology of hearing loss study

Cited by 4 publications

References 32 publications

Prevalence and incidence of hearing impairment among adults: a 13-year follow-up study

Prevalence and incidence of hearing impairment among adults: a 13-year follow-up study

Establishing multifactorial risk factors for adult-onset hearing loss: A systematic review with topic modelling and synthesis of epidemiological evidence

Micro Injection Molding of Drug-Loaded Round Window Niche Implants for an Animal Model Using 3D-Printed Molds

Contact Info

Product

Resources

About