J. Neurosci. Res. volume 86, issue 5, P1132-1141 2008 DOI: 10.1002/jnr.21569 View full text
Hui-Ling Zhang, Zhen-Lun Gu, Sean I. Savitz, Feng Han, Kohji Fukunaga, Zheng-Hong Qin

Abstract: We have previously reported that prostaglandin A(1) (PGA(1)) reduces infarct size in rodent models of focal ischemia. This study seeks to elucidate the possible molecular mechanisms underlying PGA(1)'s neuroprotective effects against ischemic injury. Rats were subjected to permanent middle cerebral artery occlusion (pMCAO) by intraluminal suture blockade. PGA(1) was injected intracerebroventricularly (icv) immediately after ischemic onset. Western blot analysis was employed to determine alterations in IkappaBa…

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