2019
DOI: 10.1167/iovs.18-26216
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Abstract: PurposeRetinal ischemia, a common cause of several vision-threatening diseases, contributes to the death of retinal neurons, particularly retinal ganglion cells (RGCs). Heat shock transcription factor 1 (HSF1), a stress-responsive protein, has been shown to be important in response to cellular stress stimuli, including ischemia. This study is to investigate whether HSF1 has a role in retinal neuronal injury in a mouse model of retinal ischemia-reperfusion (IR).MethodsIR was induced by inserting an infusion nee… Show more

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Cited by 31 publications
(32 citation statements)
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References 51 publications
(118 reference statements)
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“…2 B). Since plasma membrane permeability is an early hallmark of necroptotic cell death, we further used propidium iodide (PI), which cannot cross the intact membrane of live cells but can cross disrupted cell membrane, to detect necroptotic cells (Liu et al, 2019;Shosha et al, 2016;Unal Cevik and Dalkara, 2003). We found that PI-positive cells were dramatically increased in the GCL and INL of WT retinas within 12 h following ischemic injury in comparison to WT sham control, whereas Epac1 deletion reduced the number of necroptotic cells after retinal ischemia (Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…2 B). Since plasma membrane permeability is an early hallmark of necroptotic cell death, we further used propidium iodide (PI), which cannot cross the intact membrane of live cells but can cross disrupted cell membrane, to detect necroptotic cells (Liu et al, 2019;Shosha et al, 2016;Unal Cevik and Dalkara, 2003). We found that PI-positive cells were dramatically increased in the GCL and INL of WT retinas within 12 h following ischemic injury in comparison to WT sham control, whereas Epac1 deletion reduced the number of necroptotic cells after retinal ischemia (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Following ischemic injury, vascular inflammation and leakage occur within 24 h and play critical roles in further neuronal injury ( Ha et al, 2015 ; Zhang et al, 2017 ). To assess the effects of Epac1 genetic ablation in these processes, we perfusion-labeled vessels and leukocytes attached to vessels with concanavalin A (Con A; leukostasis assay) together with CD45 staining to identify all leukocytes in the retinas of WT and Epac1-deficient mice ( Liu et al, 2019 ; Rojas et al, 2010 ). As demonstrated in Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…The factors related to its appearance are inflammatory factor-mediated inflammation, free oxygen radical formation, changes in nitric oxide (NO) formation and calcium cation overload. RGCs are vulnerable to ischemia, leading to the thinning of nerve fiber layer by RGCs injury or loss [42].…”
Section: Retinal Ischemia-reperfusion Injury (Riri)mentioning
confidence: 99%
“… 31 Exogenous expression of HSP70 and HSF1 are also suggested to significantly improve the survival of injured retinal ganglion cells. 32 , 33 Along these lines, HSP70 is suggested to play a protective role in the retina, especially in stressed photoreceptors, in response to either exogenous stress stimuli or inherited mutations. 29 32 , 34 …”
mentioning
confidence: 99%