Neuroprotective effects of estradiol in hippocampal neurons and glia of middle age mice

Saravia, Flavia; Beauquis, Juan; Pietranera, Luciana; Nicola, Alejandro F. De

doi:10.1016/j.psyneuen.2007.02.012

Cited by 57 publications

(44 citation statements)

References 65 publications

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“…Previous experiments on male gerbils showed that E2 protected CA1 hippocampal neurons against global ischemia (78). These findings were corroborated by studies in which prolonged E2 treatment had protective effect in aging-related neuronal loss in hippocampus of middle-aged male mice (79). Furthermore, recent experiments have shown that E2 as well as progesterone effectively reduced cortical cell damage in male rats after transient middle cerebral artery occlusion (80).…”

Section: Functional Relevance Of E2 Treatment-induced Fiber Restorationmentioning

confidence: 69%

Postlesion Estradiol Treatment Increases Cortical Cholinergic Innervations via Estrogen Receptor-α Dependent Nonclassical Estrogen Signaling in Vivo

et al. 2011

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17β-Estradiol (E2) treatment exerts rapid, nonclassical actions via intracellular signal transduction system in basal forebrain cholinergic (BFC) neurons in vivo. Here we examined the effect of E2 treatment on lesioned BFC neurons in ovariectomized mice and the role of E2-induced nonclassical action in this treatment. Mice given an N-methyl-d-aspartic acid (NMDA) injection into the substantia innominata-nucleus basalis magnocellularis complex (SI-NBM) exhibited cholinergic cell loss in the SI-NBM and ipsilateral cholinergic fiber loss in the cortex. A single injection of E2 after NMDA lesion did not have an effect on cholinergic cell loss in the SI-NBM, but it restored the ipsilateral cholinergic fiber density in the cortex in a time- and dose-dependent manner. The most effective cholinergic fiber restoration was observed with 33 ng/g E2 treatment at 1 h after NMDA lesion. The E2-induced cholinergic fiber restoration was absent in neuron-specific estrogen receptor-α knockout mice in vivo. Selective activation of nonclassical estrogen signaling in vivo by estren induced E2-like restorative actions. Selective blockade of the MAPK or protein kinase A pathway in vivo prevented E2's ability to restore cholinergic fiber loss. Finally, studies in intact female mice revealed an E2-induced restorative effect that was similar to that of E2-treated ovariectomized mice. These observations demonstrate that a single E2 treatment restores the BFC fiber loss in the cortex, regardless of endogenous E2 levels. They also reveal the critical role of nonclassical estrogen signaling via estrogen receptor-α and protein kinase A-MAPK pathways in E2-induced restorative action in the cholinergic system in vivo.

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Section: Functional Relevance Of E2 Treatment-induced Fiber Restorationmentioning

confidence: 69%

Postlesion Estradiol Treatment Increases Cortical Cholinergic Innervations via Estrogen Receptor-α Dependent Nonclassical Estrogen Signaling in Vivo

et al. 2011

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“…For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article. neurogenesis in the dentate gyrus is associated with aging (Saravia et al, 2007), neurodegenerative disorders (Beauquis et al, 2008) and specifically with some psychiatric conditions like depression (Tanti and Belzung, 2013).…”

Section: Discussionmentioning

confidence: 99%

Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity

Vinuesa

Pomilio

Menafra

et al. 2016

Psychoneuroendocrinology

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“…Immunoreactive cells were counted in 6-8 brain sections per animal, spaced 120 μm apart and corresponding to the whole hippocampal extension according to the following coronal coordinates from bregma: −0.82 to −3.08 mm (Franklin and Paxinos, 1997). The SGZ was defined as two cell bodies wide of the hilus along the border of the GCL (Saravia et al, 2007;Denis-Donini et al, 2008). Cells were qualified as being in the SGZ if they were touching or were within the SGZ.…”

Section: Quantitative Analysismentioning

confidence: 99%

Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

Schiavon

Bonato

Milani

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

114

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Neuroprotective effects of estradiol in hippocampal neurons and glia of middle age mice

Cited by 57 publications

References 65 publications

Postlesion Estradiol Treatment Increases Cortical Cholinergic Innervations via Estrogen Receptor-α Dependent Nonclassical Estrogen Signaling in Vivo

Postlesion Estradiol Treatment Increases Cortical Cholinergic Innervations via Estrogen Receptor-α Dependent Nonclassical Estrogen Signaling in Vivo

Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity

Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

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