Neuroprotective effect of 20(R)-ginsenoside Rg3 against transient focal cerebral ischemia in rats

He, Bo; Chen, Peng; Yang, Jianyu; Yu, Yun; Zhang, Xiaochao; Yang, Renhua; Zhi-qiang, Shen

doi:10.1016/j.neulet.2012.08.022

Cited by 78 publications

(57 citation statements)

References 21 publications

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“…Oral administration of ginsenoside Rb1, which is the main bioactive component in ginseng, significantly increased cell survival in the dentate gyrus and hippocampus, which could be potentially related to its effects on memory and learning . In addition, ginsenoside Rg downregulated calpain I and caspase‐3 and attenuated neuronal apoptosis induced by cerebral I/R injury …”

Section: Resultsmentioning

confidence: 99%

“…133 In addition, ginsenoside Rg downregulated calpain I and caspase-3 and attenuated neuronal apoptosis induced by cerebral I/R injury. 134 Oral administration of P. ginseng aqueous extract on WDIAI model of TBI in rat improved its neurological functions. In addition, P. ginseng reduced the levels of MDA, nitrite, acetylcholinesterase (AChE), TNFα, and IL-6 and increased GSH, SOD, and CAT in hippocampus and cerebral cortex.…”

Section: Malva Sylvestrismentioning

confidence: 98%

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Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI, fluid percussion injury, cold injury, weight drop impact acceleration injury, lateral fluid percussion, cortical impact injury, and blast injury. Studies with Actaea racemosa, Artemisia annua, Aframomum melegueta, Carthamus tinctorius, Cinnamomum zeylanicum, Crocus sativus, Cnidium monnieri, Curcuma longa, Gastrodia elata, Malva sylvestris, Da Chuanxiong Formula, Erigeron breviscapus, Panax ginseng, Salvia tomentosa, Satureja khuzistanica, Nigella sativa, Drynaria fortune, Dracaena cochinchinensis, Polygonum cuspidatum, Rosmarinus officinalis, Rheum tanguticum, Centella asiatica, and Curcuma zedoaria show a significant decrease in neuronal injury by different mechanisms such as increasing superoxide dismutase and catalase activities, suppressing nuclear factor kappa B (NF‐κB), interleukin 1 (IL‐1), glial fibrillary acidic protein, and IL‐6 expression. The aim of this study was to evaluate the neuroprotective effects of medicinal plants in central nervous system pathologies by reviewing the available literature.

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Section: Resultsmentioning

confidence: 99%

Section: Malva Sylvestrismentioning

confidence: 98%

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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“…More than sixty different ginsenosides (such as Rg 1 , Rg 2 , Rg 3 ) have been identified in ginseng and have played important roles in multifunctional properties (Kim et al, 2011;Liu et al, 2010). For instance, anti-cancer effects of Rh 2 (Gu et al, 2009), neuroprotective effects of Rb 1 , Rg 1 , Rd, Rb 3 , 20(R)-Rg 3 , and Rg 2 (Fang et al, 2012;He et al, 2012;Li, Liu, Dluzen, & Jin, 2007;Liao, Newmark, & Zhou, 2002;Peng et al, 2009;Zhang, Pi, et al, 2012), cardio-protective effects of Rb 3 (Wang, Yu, Qu, Xu, & Sui, 2010), anti-diabetic effects of Rc , antinociception & regulate intestinal motility effects of Rf Mogil, Shin, McCleskey, Kim, & Nah, 1998), anticoagulant activities effects of Rg 1 and Rg 2 (Li, Wang, & Xu, 2013), and vasodilating effects of Rg 3 (Kim et al, 2003), have been widely investigated. All in all, ginsenosides are known as the main active compounds in ginseng, having various bioactive and pharmacological activities .…”

Section: Introductionmentioning

confidence: 99%

Ginsenosides and amino acids in flavored ginseng chips as affected by food formulation and processing technology

Chen¹,

Du²,

Cai³

et al. 2015

LWT - Food Science and Technology

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“…Furthermore, we investigated the relations between the effects of LBP and the mitochondrial apoptosis pathway in mice brains after stroke. Nimodipine, as a classic clinic drug in stroke, has shown obviously beneficial effects on active treatment in previous studies [20], [21]. So it was also used as a positive control in this study.…”

Section: Introductionmentioning

confidence: 99%

Lycium barbarum Polysaccharide Prevents Focal Cerebral Ischemic Injury by Inhibiting Neuronal Apoptosis in Mice

Wang

et al. 2014

PLoS ONE

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Aims of the StudyTo investigate the neuroprotective effect of Lycium barbarum polysaccharide (LBP) on focal cerebral ischemic injury in mice and to explore its possible mechanism.Materials and MethodsMale ICR mice were used to make the model of middle cerebral artery occlusion (MCAO) after intragastric administration with LBP (10, 20 and 40 mg/kg) and Nimodipine (0.4 mg/kg) for seven successive days. After 24 h of reperfusion, neurological scores were estimated and infarct volumes were measured by 2, 3, 5-triphenyltetrazolium chloride (TTC) staining. Morphological changes in ischemic brains were performed for hematoxylin-eosin (HE) staining. The number of apoptotic neurons was detected by TUNEL staining. The Bax, Bcl-2 protein expression and CytC, Caspase-3, -9 and cleaved PARP-1 activation were investigated by immunofluorescence and western-blot analysis.ResultsLBP (10, 20 and 40 mg/kg) treatment groups significantly reduced infract volume and neurological deficit scores. LBP also relieved neuronal morphological damage and attenuated the neuronal apoptosis. LBP at the dose of 40 mg/kg significantly suppressed overexpression of Bax, CytC, Caspase-3, -9 and cleaved PARP-1, and inhibited the reduction of Bcl-2 expression.ConclusionsBased on these findings we propose that LBP protects against focal cerebral ischemic injury by attenuating the mitochondrial apoptosis pathway.

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Neuroprotective effect of 20(R)-ginsenoside Rg3 against transient focal cerebral ischemia in rats

Cited by 78 publications

References 21 publications

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Ginsenosides and amino acids in flavored ginseng chips as affected by food formulation and processing technology

Lycium barbarum Polysaccharide Prevents Focal Cerebral Ischemic Injury by Inhibiting Neuronal Apoptosis in Mice

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