Neuroprotective compounds isolated from Cynanchum paniculatum

Weon, Jin Bae; Kim, Chul Young; Yang, Hye Jin; Je, Choong

doi:10.1007/s12272-012-0404-4

Cited by 24 publications

(15 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gallic acid and vanillic acid showed neuroprotective effect, AchE inhibitory activity and antioxidant effect (Ban et al ., 2008; Ghayur et al ., 2011; Gan et al ., 2011; Weon et al ., 2012). Ferulic acid was also protected against memory and learning deficit induced β-amyloid peptide in mice and had antioxidant activity (Cho et al ; 2005).…”

Section: Disscusionmentioning

confidence: 99%

Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata

Weon

Yun

Lee

et al. 2014

Biomolecules & Therapeutics

Self Cite

View full text Add to dashboard Cite

Codonopsis lanceolata has been used as an herbal medicine for several lung inflammatory diseases, such as asthma, tonsillitis, and pharyngitis. Previously, we showed the neuroprotective effect of steamed and fermented C. lanceolata (SFC) in vitro and in vivo. In the current study, the treatment of HT22 cells with SFC decreased glutamate-induced cell death, suggesting that SFC protected HT22 cells from glutamate-induced cytotoxicity. Based on these, we sought to elucidate the mechanisms of the neuro-protective effect of SFC by measuring the oxidative stress parameters and the expression of Bax and caspase-3 in HT22 cells. SFC reduced contents of ROS, Ca2+ and NO. Moreover, SFC restored contents of glutathione and glutathione reductase as well as inhibited Bax and caspase-3 activity in HT22 cells. These results indicate that steamed and fermented C. lanceolata (SFC) extract protected HT22 cells by anti-oxidative effect and inhibition of the expression of Bax and caspase-3.

show abstract

Section: Disscusionmentioning

confidence: 99%

Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata

Weon

Yun

Lee

et al. 2014

Biomolecules & Therapeutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…[13] In addition, the present study isolated compound from C. paniculatum and identified it as 4,5-dimethoxypyrocatechol. Also, 4,5-dimethoxypyrocatechol showed neuroprotective effect against glutamate-induced cell death in HT22 cell.…”

Section: Discussionmentioning

confidence: 81%

“…[1112] We isolated 10 compounds, paeonol, 4-acetylphenol, 2,5-dihydroxy-4-methoxyacetophenone, 2,3-dihydroxy-4-methoxyacetophenone, acetoveratrone, 2,5-dimethoxyhydroquinone, vanillic acid, resacetophenone, m-acetylphenol, and 3,5-dimethoxy-hydroquinone from C. paniculatum and investigated their neuroprotective effects. [13]…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of 4,5-dimethoxypyrocatechol isolated from Cynanchum paniculatum on HT22 cells

Weon¹,

Lee²,

Yun³

et al. 2014

Phcog Mag

View full text Add to dashboard Cite

Background:Cynanchum paniculatum, belongs to the family Asclepiadaceae and is used to treat various diseases, such as invigorate blood, alleviate edema and to relieve pain and toxicity for a long time.Materials and Methods:4,5-Dimethoxypyrocatechol was isolated from the 80% methanol extract of C. paniculatum and its neuroprotective effect was evaluated by MTT assay.Results:4,5-Dimethoxypyrocatechol had neuroprotective effect on the glutamate-induced cellular oxidative death in HT22 cells.Conclusion:Furthermore, we found that reactive oxygen species (ROS) accumulation and calcium concentration by oxidative stress were reduced by 4,5-dimethoxypyrocatechol in HT22 cells.

show abstract

Section: Disscusionmentioning

confidence: 99%

Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata

Weon¹,

Yun²,

Lee³

et al. 2014

Biomol Ther

Self Cite

View full text Add to dashboard Cite

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. www.biomolther.orgCodonopsis lanceolata has been used as an herbal medicine for several lung infl ammatory diseases, such as asthma, tonsillitis, and pharyngitis. Previously, we showed the neuroprotective effect of steamed and fermented C. lanceolata (SFC) in vitro and in vivo. In the current study, the treatment of HT22 cells with SFC decreased glutamate-induced cell death, suggesting that SFC protected HT22 cells from glutamate-induced cytotoxicity. Based on these, we sought to elucidate the mechanisms of the neuroprotective effect of SFC by measuring the oxidative stress parameters and the expression of Bax and caspase-3 in HT22 cells. SFC reduced contents of ROS, Ca 2+ and NO. Moreover, SFC restored contents of glutathione and glutathione reductase as well as inhibited Bax and caspase-3 activity in HT22 cells. These results indicate that steamed and fermented C. lanceolata (SFC) extract protected HT22 cells by anti-oxidative effect and inhibition of the expression of Bax and caspase-3.

show abstract

Neuroprotective compounds isolated from Cynanchum paniculatum

Cited by 24 publications

References 18 publications

Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata

Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata

Neuroprotective effects of 4,5-dimethoxypyrocatechol isolated from Cynanchum paniculatum on HT22 cells

Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata

Contact Info

Product

Resources

About