Neuroprotective Activity of Garcinia pedunculata Roxb ex Buch Ham Fruit Extract Against Aluminium Chloride Induced Neurotoxicity in Mice

Mundugaru, Ravi; Narayana, Sunil Kumar Koppala; Ballal, Shrinidhi; Thomas, J.; Rajakrishnan, R.

doi:10.5530/ijper.50.3.17

Cited by 6 publications

(6 citation statements)

References 17 publications

(17 reference statements)

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“…Phytochemical studies have shown that the dry fruits contain hydroxylcitric acid, benzophenones, garcinol, pedunculol, and isogarcinol (cambogin), the first having been reported as possessing antioxidant activity [ 16 ], and the second and third with anticancer, anti-inflammatory, and antiparasitic activities [ 24 , 70 ]. Dry fruits have been selected for different actions and have shown anti-inflammatory, hepatoprotective, cardioprotective, and antioxidant pharmacological activities in vitro [ 71 , 72 ].…”

Section: Garcinia Species and Bioactive Compounmentioning

confidence: 99%

“…The following components have been isolated from the epicarp of G. brasiliensis fruit: a new glycosylated biflavonone, morelloflavone-4 -O-β-d-glycosyl (16), and the known compounds 1,3,6,7-tetrahydroxyxanthone (norathyriol; 17), morelloflavone (fukugetin; 9), and morelloflavone-7 -O-β-d-glycosyl (fukugesid; 18). These compounds presented antioxidant activity after the isolation of natural biflavonoids from the plant [41].…”

Section: Garcinia Brasiliensismentioning

confidence: 99%

“…Thus, species of the genus Garcinia have proved to be rich sources of compounds with relevant therapeutical properties [ 7 , 8 , 10 , 11 ]. Garcinia species are rich in secondary metabolites, such as prenylated and oxygenated xanthones [ 11 ] with biological activities such as antifungal [ 12 ], anti-inflammatory [ 13 ], antitumoral [ 14 ], antioxidant [ 15 , 16 ], Human Immunodeficiency Virus (HIV)-inhibitory [ 7 ], and antilipidemic properties [ 14 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Medicinal Potential of Garcinia Species and Their Compounds

et al. 2020

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Garcinia is a genus of Clusiaceae, distributed throughout tropical Asia, Africa, New Caledonia, Polynesia, and Brazil. Garcinia plants contain a broad range of biologically active metabolites which, in the last few decades, have received considerable attention due to the chemical compositions of their extracts, with compounds which have been shown to have beneficial effects in several diseases. Our work had the objective of reviewing the benefits of five Garcinia species (G. brasiliensis, G. gardneriana, G. pedunculata, G. cambogia, and G. mangstana). These species provide a rich natural source of bioactive compounds with relevant therapeutic properties and anti-inflammatory effects, such as for the treatment of skin disorders, wounds, pain, and infections, having demonstrated antinociceptive, antioxidant, antitumoral, antifungal, anticancer, antihistaminic, antiulcerogenic, antimicrobial, antiviral, vasodilator, hypolipidemic, hepatoprotective, nephroprotective, and cardioprotective properties. This demonstrates the relevance of the genus as a rich source of compounds with valuable therapeutic properties, with potential use in the prevention and treatment of nontransmissible chronic diseases.

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Section: Garcinia Species and Bioactive Compounmentioning

confidence: 99%

Section: Garcinia Brasiliensismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Medicinal Potential of Garcinia Species and Their Compounds

et al. 2020

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“…It has been traditionally used in tropical regions for its diverse medicinal properties. Evidence suggests that many important phytocompounds with anti-oxidant, anti-diabetic, anti-hyperlipidemic, anti-allergic, hepatoprotective, antibacterial, anti-inflammatory, neuroprotective as well as anti-cancer effects have been isolated from the fruit rind of Garcinia [10][11][12][13][14][15][16][17][18]. Garcinia plant is loaded with phenolic components including flavonoids, xanthones, benzophenones.…”

Section: Introductionmentioning

confidence: 99%

Molecular docking prediction and in vitro studies elucidate anti-inflammatory effect of Garcinia extract against inducible nitric oxide synthase and cyclooxygenase-2 targets

Kalita

Das

et al. 2022

Beni-Suef Univ J Basic Appl Sci

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Background Garcinia is a tropical plant that has been traditionally used in medicinal folklore for its potential antioxidant, antibacterial, anti-hyperlipidemic, anti-diabetic, hepatoprotective, etc. In this study, methanolic extract of Garcinia herbal supplement (GME) and its important phytoconstituents (Garcinol and hydroxycitric acid) were evaluated for their inhibitory action against important inflammatory markers iNOS and COX-2 in lipopolysaccharide-induced RAW 264.7 cells. iNOS and COX-2 play a major role in the process of inflammation, and inhibition of these molecules will help to alleviate the inflammatory process. The cells were pre-treated with two doses of GME (115 µg/ml and 230 µg/ml); Ggarcinol (6 µM and 12 µM); hydroxycitric acid (17.5 µg/ml and 35 µg/ml) followed by stimulation with 1 µg/ml of LPS for 24 h. Results The results of the study demonstrated that Garcinia and its active components Garcinol and HCA play an important role in suppressing LPS-induced relative mRNA expression of iNOS, COX-2, and subsequent reduction in the levels of total nitric oxide and prostaglandinE2. Molecular docking analysis of Ggarcinol and HCA with iNOS and COX-2 proteins showed potent interactions with negative binding energies. Conclusions This study suggests that Garcinia possess anti-inflammatory activity thus providing a possibility for drug designing as iNOS and COX-2 inhibitor. Graphical Abstract

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“…It has been traditionally used in the tropical regions for its diverse medicinal properties. Evidence suggests that many important phytocompounds with anti-oxidant, anti-diabetic, anti-hyperlipidemic, anti-allergic, hepatoprotective, antibacterial, anti-in ammatory, neuroprotective as well as anti-cancer effects have been isolated from the fruit rind of Garcinia [10][11][12][13][14][15][16][17][18]. Garcinia plant is loaded with phenolic components including avonoids, xanthones, benzophenones.…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking Prediction and in Vitro Studies Elucidate Anti-inflammatory Effect of Garcinia Extract Against Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Targets

Kalita

Das

et al. 2021

Preprint

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Garcinia is a tropical plant that has been traditionally used in medicinal folklore for its potential antioxidant, antibacterial, anti-hyperlipidemic, anti-diabetic, hepatoprotective, etc. In this study, Garcinia herbal extract (GHE) and one of its important phytocompound (garcinol) were evaluated for their inhibitory action against important inflammatory markers inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced RAW 264.7 cells. iNOS and COX-2 plays an major role in the process of inflammation and inhibition of these molecules will help to alleviate the inflammatory process. The cells were pre-treated with two doses of Garcinia (230µg/ml and 115µg/ml); garcinol (12µM and 6µM) followed by stimulation with 1µg/ml of LPS for 24h. The results of the study demonstrated that GHE and garcinol plays an important role in suppressing LPS- induced relative mRNA expression of iNOS, COX-2 and subsequent reduction in the levels of nitric oxide and prostaglandin E 2 . Molecular docking analysis of garcinol and hydroxycitric acid, the major active components of GHE with iNOS and COX-2 proteins showed potent interaction with low binding energies. This study suggests that GHE (containing high percentage of HCA) and garcinol may possess anti-inflammatory activity thus providing a possibility for drug designing as iNOS and COX-2 inhibitors.

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Neuroprotective Activity of Garcinia pedunculata Roxb ex Buch Ham Fruit Extract Against Aluminium Chloride Induced Neurotoxicity in Mice

Cited by 6 publications

References 17 publications

Medicinal Potential of Garcinia Species and Their Compounds

Medicinal Potential of Garcinia Species and Their Compounds

Molecular docking prediction and in vitro studies elucidate anti-inflammatory effect of Garcinia extract against inducible nitric oxide synthase and cyclooxygenase-2 targets

Molecular Docking Prediction and in Vitro Studies Elucidate Anti-inflammatory Effect of Garcinia Extract Against Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Targets

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