J. Neurosci. Res. volume 86, issue 13, P2973-2983 2008 DOI: 10.1002/jnr.21728 View full text
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Cui Zhou, Chong Li, Hong-Min Yu, Fa Zhang, Dong Han, Guang-Yi Zhang

Abstract: It is well documented that exitotoxicity induced by N-methyl-D-aspartate (NMDA) receptor activation plays a pivotal role in delayed neuronal death in the hippocampal CA1 region after transient global ischemia. However, the effect of gamma-aminobutyric acid (GABA) receptor activation is uncertain in ischemia brain injury. The aim of this study was to investigate whether the enhancement of GABA receptor activity could inhibit NMDA receptor-mediated nitric oxide (NO) production by neuronal NO synthase (nNOS) in b…

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