Neurophysiological, psychological and behavioural correlates of rTMS treatment in alcohol dependence

Felice, Alessandra Del; Bellamoli, Elisa; Formaggio, Emanuela; Manganotti, Paolo; Masiero, Stefano; Cuoghi, Giuseppe; Rimondo, Claudia; Genetti, Bruno; Sperotto, Milena; Corso, F; Brunetto, Giampaolo; Bricolo, Francesco; Gomma, M.; Serpelloni, Giovanni

doi:10.1016/j.drugalcdep.2015.11.018

Cited by 72 publications

(53 citation statements)

References 57 publications

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“…(Gay et al, ). Similar results were found for people with alcohol dependence (Del Felice et al, ), with HF rTMS over the left DLPFC improving performance of a cognitive inhibition control task but ineffective at reducing alcohol intake. We can only speculate on these results.…”

Section: Discussionsupporting

confidence: 77%

“…These results agree with the few studies available in clinical samples. Del Felice et al () found that HF rTMS over the left DLPFC improved inhibitory control in alcohol dependence. Similarly, McClelland et al () found that HF rTMS over the left DLPFC transiently reduced core symptoms of anorexia nervosa and encouraged prudent decision‐making.…”

Section: Discussionmentioning

confidence: 99%

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Improving decision‐making and cognitive impulse control in bulimia nervosa by rTMS: An ancillary randomized controlled study

Guillaume

Jaussent

Sigaud

et al. 2018

Intl J Eating Disorders

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Objective Impaired decision‐making and inhibitory control may be involved in the pathophysiology of psychiatric disorders like bulimia nervosa (BN). Their improvement after neuromodulation may underpin clinical improvement. We assessed the effects of rTMS on these cognitive functions in a sample of women with BN. Methods Thirty‐nine participants (22 in a sham group and 17 in an rTMS group) were assessed before and after 10 high frequency rTMS sessions over the left dorsolateral prefrontal cortex (DLPFC). Results The between‐group analyses revealed no differences in the final neuropsychological performances. The within‐group analyses showed that inhibitory control improved in both the go/no‐go task (p = .03) and the BIS cognitive impulsivity subscale (p = .01) in the rTMS group only. Switches toward good choices on the Iowa gambling task significantly improved in the rTMS group only (p = .002), and understanding of the task contingencies increased between the two assessments, also in the rTMS group only (p = .03). Discussion This preliminary evidence suggests that modulation of left DLPFC might improve two putative cognitive biomarkers of BN.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Improving decision‐making and cognitive impulse control in bulimia nervosa by rTMS: An ancillary randomized controlled study

Guillaume

Jaussent

Sigaud

et al. 2018

Intl J Eating Disorders

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“…Only studies whose primary and/or secondary outcomes were related to substance use outcomes (ie, consumption, abstinence, craving, and withdrawal) or drug cue‐induced neurophysiological/functional imaging changes were included in this review. This process yielded 69 studies, of which nine were excluded that did not meet these criteria.…”

Section: Methodsmentioning

confidence: 99%

A review of brain stimulation methods to treat substance use disorders

2018

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Background Substance use disorders (SUDs) are a leading cause of disability worldwide. While several pharmacological and behavioral treatments for SUDs are available, these may not be effective for all patients. Recent studies using non-invasive neuromodulation techniques including Repetitive Transcranial Magnetic Stimulation (rTMS), Transcranial Direct Current Stimulation (tDCS), and Deep Brain Stimulation (DBS) have shown promise for SUD treatment. Objective Multiple studies were evaluated investigating the therapeutic potential of non-invasive brain stimulation techniques in treatment of SUDs. Method Through literature searches (eg, PubMed, Google Scholar), 60 studies (2000–2017) were identified examining the effect of rTMS, tDCS, or DBS on cravings and consumption of SUDs, including tobacco, alcohol, cannabis, opioids, and stimulants. Results rTMS and tDCS demonstrated decreases in drug craving and consumption, while early studies with DBS suggest similar results. Results are most encouraging when stimulation is targeted to the Dorsolateral Prefrontal Cortex (DLPFC). Conclusions Short-term treatment with rTMS and tDCS may have beneficial effects on drug craving and consumption. Future studies should focus on extending therapeutic benefits by increasing stimulation frequency and duration of treatment. Scientific Significance The utility of these methods in SUD treatment and prevention are unclear, and warrants further study using randomized, controlled designs.

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“…Furthermore, the present protocol delivered 20 rTMS pulses using inter-train intervals of 10 or 11 s. On the one hand, the current safety guideline considers 5 s or longer intertrain intervals to be safe up to 110% motor threshold [24]. Yet, 10 Hz rTMS studies usually employ substantially longer inter-train intervals that are in the range of 20 to 68 s [e.g., 25,26]. One can avoid this potential safety concern in future studies by at least doubling the inter-train intervals used in the present study.…”

Section: Relation Of Electric Field Strengths To Previous Tacs and Rtmentioning

confidence: 99%

Weak rTMS-induced electric fields produce neural entrainment in humans

Zmeykina¹,

Mittner²,

Paulus³

et al. 2019

Preprint

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Repetitive transcranial magnetic stimulation (rTMS) is a potent tool for modulating endogenous oscillations in humans. The current standard dosing method for rTMS defines the electric field strength only indirectly. A better characterization of the electric field strength induced by a given rTMS protocol is necessary in order to improve the understanding of the neural mechanisms of rTMS. In this study we used a novel approach, in which individualized prospective computational modeling of the induced electric field guided the choice of stimulation intensity. We consistently found that rhythmic rTMS protocols increased neural synchronization in the posterior alpha frequency band when measured simultaneously with scalp electroencephalography. We observed this effect already at electric field strengths of roughly half the lowest conventional dose, which is 80% of the resting motor threshold. We conclude that rTMS can induce immediate electrophysiological effects at much weaker electric field strengths than previously thought.

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Neurophysiological, psychological and behavioural correlates of rTMS treatment in alcohol dependence

Cited by 72 publications

References 57 publications

Improving decision‐making and cognitive impulse control in bulimia nervosa by rTMS: An ancillary randomized controlled study

Improving decision‐making and cognitive impulse control in bulimia nervosa by rTMS: An ancillary randomized controlled study

A review of brain stimulation methods to treat substance use disorders

Weak rTMS-induced electric fields produce neural entrainment in humans

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