Neuropeptides: Potential neuroprotective agents in ischemic injury

Saklani, Priyanka; Khan, Heena; Gupta, Saurabh; Kaur, Amandeep; Singh, Thakur Gurjeet

doi:10.1016/j.lfs.2021.120186

Cited by 38 publications

(16 citation statements)

References 155 publications

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“…Increased prolactin and oxytocin levels during breastfeeding may be involved in the peripheral neuroprotection of breastfeeding. 30–34 Inflammation and oxidative stress play crucial roles in peripheral neuropathy. 10 As a mediator of inflammation, tumor necrosis factor (TNF-α) can directly cause peripheral nerve injury and influence peripheral nerves by causing endothelial dysfunction and vascular thickening.…”

Section: Discussionmentioning

confidence: 99%

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Association Between Breastfeeding and Reduced Distal Sensory Polyneuropathy in Postmenopausal Women Aged 40–70 Years: Analysis of Data from the 1999–2004 National Health and Nutrition Examination Survey

Santibenchakul

Chongpison

et al. 2023

Breastfeeding Medicine

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Background: Distal sensory polyneuropathy (DSP) is a common peripheral neuropathy subtype. We aimed to determine the association between breastfeeding and DSP among postmenopausal women aged 40–70 years, and the effect modification of obesity on this association. Methods: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey 1999–2004. Postmenopausal women aged 40–70 years were included. Women with diabetes, stroke, cancer, cardiovascular disease, thyroid disease, liver disease, weak/failing kidneys, or amputation were excluded. Binary logistic regression was used to analyze the association between breastfeeding and DSP. Results: Among 798 participants, 386 (44.30%) reported breastfeeding history and 51 (5.29%) were defined as having DSP using the monofilament test. A significant inverse association was observed between breastfeeding and DSP (odds ratio [OR] = 0.29; 95% confidence interval [CI]: 0.11–0.79; p = 0.017) after adjusting for other confounding variables. In subgroup analysis, this adjusted association was observed only in the obese group (OR = 0.21; 95% CI: 0.06–0.73, p = 0.013). Conclusions: Breastfeeding was found to have potential benefits in the presence of DSP in postmenopausal women aged 40–70 years, and obesity modified the association between breastfeeding and DSP. Promoting breastfeeding may reduce the burden of peripheral neuropathy in middle-aged postmenopausal women.

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Section: Discussionmentioning

confidence: 99%

“… 35 Oxytocin acts as a neuroprotective factor by preventing ischemia-induced inflammation and oxidative stress by regulating NF-κB, TNF-α, IL-1β, and microglial activation. 30–32 …”

Section: Discussionmentioning

confidence: 99%

Association Between Breastfeeding and Reduced Distal Sensory Polyneuropathy in Postmenopausal Women Aged 40–70 Years: Analysis of Data from the 1999–2004 National Health and Nutrition Examination Survey

Santibenchakul

Chongpison

et al. 2023

Breastfeeding Medicine

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“…Corticotropin-releasing factor (CRF) has been shown to have opposing effects to neuropeptide Y in the control of inhibitory transmission [ 100 ], whilst substance P facilitates excitatory glutamatergic transmission by prolonging activation of NMDA receptors [ 101 ]. Neuropeptides including neuropeptide Y, calcitonin gene-related peptide (CGRP), PACAP and bradykinin have also been shown to exert neuroprotective effects by reducing excitotoxicity and apoptosis and exerting anti-inflammatory and antioxidant actions on neurons following brain injury [ 102 , 103 ]. Therefore, neuropeptides have essential roles in the control of neuronal homeostasis and recovery following insult to the brain, excitatory/inhibitory neurotransmission, and synaptic plasticity associated with learning and memory.…”

Section: Neuromodulator Function In the Central Nervous System And Dy...mentioning

confidence: 99%

Alternative Pharmacological Strategies for the Treatment of Alzheimer’s Disease: Focus on Neuromodulator Function

et al. 2022

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Alzheimer’s disease (AD) is a neurodegenerative disorder, comprising 70% of dementia diagnoses worldwide and affecting 1 in 9 people over the age of 65. However, the majority of its treatments, which predominantly target the cholinergic system, remain insufficient at reversing pathology and act simply to slow the inevitable progression of the disease. The most recent neurotransmitter-targeting drug for AD was approved in 2003, strongly suggesting that targeting neurotransmitter systems alone is unlikely to be sufficient, and that research into alternate treatment avenues is urgently required. Neuromodulators are substances released by neurons which influence neurotransmitter release and signal transmission across synapses. Neuromodulators including neuropeptides, hormones, neurotrophins, ATP and metal ions display altered function in AD, which underlies aberrant neuronal activity and pathology. However, research into how the manipulation of neuromodulators may be useful in the treatment of AD is relatively understudied. Combining neuromodulator targeting with more novel methods of drug delivery, such as the use of multi-targeted directed ligands, combinatorial drugs and encapsulated nanoparticle delivery systems, may help to overcome limitations of conventional treatments. These include difficulty crossing the blood-brain-barrier and the exertion of effects on a single target only. This review aims to highlight the ways in which neuromodulator functions are altered in AD and investigate how future therapies targeting such substances, which act upstream to classical neurotransmitter systems, may be of potential therapeutic benefit in the sustained search for more effective treatments.

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“…With their wide distribution in the human body, neuropeptides are peptidergic neurotransmitters, modulators, or hormones that modulate the central and peripheral nervous systems [12][13][14][15]. As a potential growth factor for normal cells, it can mediate tumor cell proliferation and differentiation through autocrine, paracrine, neurosecretory, and endocrine mechanisms [16,17].…”

Section: Introductionmentioning

confidence: 99%

Prognostic and Functional Analysis of NPY6R in Uveal Melanoma Using Bioinformatics

Mei

Kang

2022

Disease Markers

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Neuropeptides can mediate tumor cell proliferation and differentiation through autocrine, paracrine, neurosecretory, and endocrine mechanisms. This study investigated the expression and prognostic significance of neuropeptide Y receptor Y6 (NPY6R) in uveal melanoma (UVM) and preliminarily investigated the biological function of NPY6R in UVM. NPY6R was poorly expressed in most tumors and was associated with better prognosis in UVM. Among the clinicopathological features of UVM, NPY6R expression was lower in male patients. The area under the curve (AUC) value of NPY6R for the diagnosis of UVM was 0.676 (95% CI: 0.556–0.795). A nomogram including four clinical predictors was constructed. NPY6R expression was significantly associated with features of the UVM immune microenvironment. ESTIMATE and CIBERSORT algorithms were used to calculate the fraction of immune cells and the percentage of infiltration in each patient, respectively. NPY6R expression-related gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analyses were performed. GO and KEGG enrichment analyses revealed that NPY6R-related genes are mainly enriched in pathways and functions related to visual light perception. Gene set enrichment analysis suggested that NPY6R is associated with tumor progression in UVM. NPY6R is involved in the tumor progression of UVM and has a good predictive value as a prognostic marker of UVM.

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Neuropeptides: Potential neuroprotective agents in ischemic injury

Cited by 38 publications

References 155 publications

Association Between Breastfeeding and Reduced Distal Sensory Polyneuropathy in Postmenopausal Women Aged 40–70 Years: Analysis of Data from the 1999–2004 National Health and Nutrition Examination Survey

Association Between Breastfeeding and Reduced Distal Sensory Polyneuropathy in Postmenopausal Women Aged 40–70 Years: Analysis of Data from the 1999–2004 National Health and Nutrition Examination Survey

Alternative Pharmacological Strategies for the Treatment of Alzheimer’s Disease: Focus on Neuromodulator Function

Prognostic and Functional Analysis of NPY6R in Uveal Melanoma Using Bioinformatics

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