Neuropeptide Y Reverses Chronic Stress-induced Baroreflex Hypersensitivity in Rats

Xie, Fang; Sun, Lihua; Su, Xiaolin; Wang, Ying; Liu, Jing; Zhang, Rong; Wang, Ning; Zhao, Jing; Ban, Takahiko; Niu, Huifang; Ai, Jing

doi:10.1159/000338500

Cited by 9 publications

(12 citation statements)

References 55 publications

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“…This is an important homeostatic mechanism in the whole body for self-protective functions. Xie et al found that long-term NPY administration induced abnormal baroreflex sensitivity but reversed chronic stressinduced baroreflex hypersensitivity in rats [28,43], providing the evidence of the double controlled role of NPY depending on specific conditions. It's very meaningful to illustrate the effect of NPY on heart function at different time points.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Administration of Neuropeptide Y in the Subcutaneous Infusion Results in Cardiac Dysfunction and Hypertrophy in Rats

Zhang

Niu

Kang

et al. 2015

Cell Physiol Biochem

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Background/Aims: The purpose of the present study was to clarify whether chronically elevated plasma neuropeptide Y (NPY) might affect heart function and cardiac remodeling in rats. Methods: Male Wistar rats were administered NPY (85 μg for 30 days) by mini-osmotic pump subcutaneously implanted between the scapulae. Associated indices for heart function, cardiac remodeling and hypertrophy were evaluated. Results: Compared to the sham group, the baseline systolic blood pressure (SBP) in rats administered NPY was significantly increased; cardiac function was significantly decreased, as indicated by reduced ejection fraction (EF), left ventricular end-systolic pressure (LVESP), maximum change velocity of left ventricular pressure in the isovolumic contraction or relaxation period (±dp/dt_max) and increased left ventricular end-diastolic pressure (LVEDP); hematoxylin-eosin (H&E) staining detection displayed enlarged cell areas and a consistent increase in heart-to-body weight ratios (HW/BW) was observed; quantitative real time PCR (qRT-PCR) and Western blot analysis showed markedly increased expressions of β-myosin heavy chain (β-MHC), calcineurin (CaN) and phosphorylated p38 proteins, while no changes were found in the expressions of p38 total protein and the phosphorylations of JNK and ERK. Conclusion: This study reported for the first time that long-term elevated plasma concentration of NPY could induce cardiac dysfunction and cardiac hypertrophy and this phenomenon could, in part, be mediated by the Ca²⁺/CaM-dependent CaN pathway and p38 mitogen-activated protein kinase (MAPK) signal pathway in rats.

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Section: Discussionmentioning

confidence: 99%

Long-Term Administration of Neuropeptide Y in the Subcutaneous Infusion Results in Cardiac Dysfunction and Hypertrophy in Rats

Zhang

Niu

Kang

et al. 2015

Cell Physiol Biochem

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“…A minor pocket was made with a hemostat by spreading the subcutaneous connective tissues apart, the pump was inserted into the pocket while orienting the flow moderator to point to the opposite direction of the incision, and the incision was closed with wound sutures [17,18]…”

Section: Methodsmentioning

confidence: 99%

“…Elevated levels of plasma NPY have also been proposed as a prognostic marker for coronary diseases [13], heart failure [14] and myocardial ischemia [15]. Our previous studies demonstrated that long-term NPY administration led to abnormal BRS, and reversed chronic stress-induced baroreflex hypersensitivity in rats [16,17]. Clinical investigation has shown that the level of plasma NPY is positively correlated with the insulin level for patients with T2DM [18].…”

Section: Introductionmentioning

confidence: 99%

Blockage of Peripheral NPY Y1 and Y2 Receptors Modulates Barorefex Sensitivity of Diabetic Rats

Liu

Wang²,

Xie³

et al. 2013

Cell Physiol Biochem

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Background/Aims: Abnormal baroreceptor reflex sensitivity (BRS) and elevated plasma neuropeptide Y (NPY) are prevalent in diabetic patients. The present study was conducted to determine whether NPY Y1 receptor (Y1R) and NPY Y2 receptor (Y2R) contribute to the regulatin of BRS in diabetic rats. Methods: Diabetes mellitus (DM) rats with hyperlipidemia were developed by an emulsion diet enriched with fat, sucrose and fructose followed by streptozocin (STZ). Y1R and Y2R specific antagonists (BIBP 3226 and BIIE 0246) were administered by a mini-osmotic pump. Systolic blood pressure (SBP), heart rate (HR), BRS and heart functions, as well as the plasma NPY and lipid level were measured after treatment for 4 weeks. Results: Both BIBP 3226 and BIIE 0246 treatment reversed the elevated total cholesterol (TC) and low density lipoprotein (LDL-C) level, and reduced high density lipoprotein (HDL-C) level in DM rats. BIIE 0246 may attenuate the increased triglyceride (TG) level in DM rats. In addition, neither BIBP 3226 nor BIIE 0246 treatment produced significant effects on BRS, SBP or HR (P>0.05) in DM rats, even after PE and SNP challenge. However, BIBP 3226 and BIIE 0246 further impaired LVSP, LVEDP, +dp/dt_max and -dp/dt_max. Conclusion: This study provided us with the evidence that the inhibition of peripheral Y1R and Y2R did not affect impaired BRS but amplified the deterioration of the compromised cardiac function in STZ-induced DM rats with hyperlipidemia.

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“…These findings indicate that these experimental models of stress may increase the vulnerability and severity of cardiac complications. In addition, cardiac contractile dysfunction was reported in animals subjected to CVS protocols (Grippo et al, 2006 ; Xie et al, 2012 ).…”

Section: Cardiovascular Responses To Stress: Influence Of Chronicitymentioning

confidence: 99%

Emotional Stress and Cardiovascular Complications in Animal Models: A Review of the Influence of Stress Type

Crestani

2016

Front. Physiol.

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Emotional stress has been recognized as a modifiable risk factor for cardiovascular diseases. The impact of stress on physiological and psychological processes is determined by characteristics of the stress stimulus. For example, distinct responses are induced by acute vs. chronic aversive stimuli. Additionally, the magnitude of stress responses has been reported to be inversely related to the degree of predictability of the aversive stimulus. Therefore, the purpose of the present review was to discuss experimental research in animal models describing the influence of stressor stimulus characteristics, such as chronicity and predictability, in cardiovascular dysfunctions induced by emotional stress. Regarding chronicity, the importance of cardiovascular and autonomic adjustments during acute stress sessions and cardiovascular consequences of frequent stress response activation during repeated exposure to aversive threats (i.e., chronic stress) is discussed. Evidence of the cardiovascular and autonomic changes induced by chronic stressors involving daily exposure to the same stressor (predictable) vs. different stressors (unpredictable) is reviewed and discussed in terms of the impact of predictability in cardiovascular dysfunctions induced by stress.

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Neuropeptide Y Reverses Chronic Stress-induced Baroreflex Hypersensitivity in Rats

Cited by 9 publications

References 55 publications

Long-Term Administration of Neuropeptide Y in the Subcutaneous Infusion Results in Cardiac Dysfunction and Hypertrophy in Rats

Long-Term Administration of Neuropeptide Y in the Subcutaneous Infusion Results in Cardiac Dysfunction and Hypertrophy in Rats

Blockage of Peripheral NPY Y1 and Y2 Receptors Modulates Barorefex Sensitivity of Diabetic Rats

Emotional Stress and Cardiovascular Complications in Animal Models: A Review of the Influence of Stress Type

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