Neuropeptide B and Vaspin as New Biomarkers in Anorexia Nervosa

Grzelak, Teresa; Tyszkiewicz‐Nwafor, Marta; Dutkiewicz, Agata; Mikulska, Aniceta Ada; Dmitrzak‐Węglarz, Monika; Słopień, Agnieszka; Czyżewska, Krystyna; Paszyńska, Elżbieta

doi:10.1155/2018/9727509

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…We found that nPB and its receptor are present in rat adipocytes (11) where nPB stimulates lipolysis and suppresses leptin expression, and secretion (11). others have reported that nPB serum level is upregulated in humans who suffer from anorexia nervosa (12), while it is reduced in type 1 diabetic patients (13). overall, these results collectively indicate that the nPB/nPBW1 system is involved in controlling body weight and energy homeostasis and its alternation may contribute to obesity.…”

Section: Introductionsupporting

confidence: 67%

Neuropeptide�B stimulates insulin secretion and expression but not proliferation in rat insulin‑producing INS‑1E cells

et al. 2019

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neuropeptide B (nPB) regulates food intake, body weight and energy homeostasis by interacting with nPBW1/nPBW2 in humans and nPBW1 in rodents. nPB and nPBW1 are widely expressed in the central nervous system and peripheral tissues including pancreatic islets. although previous studies have demonstrated a prominent role for nPB and nPBW1 in controlling glucose and energy homeostasis, it remains unknown as to whether nPB modulates pancreatic β-cell functions. Therefore, the aim of the present study was to investigate the effects of nPB on insulin expression and secretion in vitro. Furthermore, the role of nPB in the modulation of inS-1e cell growth, viability and death was examined. Gene expression was assessed by reverse transcription-quantitative Pcr. cell proliferation and viability were determined by Brdu or MTT tests, respectively. apoptotic cell death was evaluated by relative quantification histone-complexed DNA fragments (mono-and oligonucleosomes). insulin secretion was studied using an eliSa test. Protein phosphorylation was assessed by western blot analysis. nPB and nPBW1 mrna was expressed in inS-1e cells and rat pancreatic islets. in inS-1e cells, nPB enhanced insulin 1 mrna expression via an erK1/2-dependent mechanism. Furthermore, nPB stimulated insulin secretion from inS-1e cells and rat pancreatic islets. By contrast, nPB failed to affect inS-1e cell growth or death. We conclude that nPB may regulate insulin secretion and expression in inS-1e cells and insulin secretion in rat pancreatic islets.

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Section: Introductionsupporting

confidence: 67%

Neuropeptide�B stimulates insulin secretion and expression but not proliferation in rat insulin‑producing INS‑1E cells

et al. 2019

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“…Discussing the contribution of NPB to appetite modulation, it is worth noting that a human study was conducted on circulating NPB in blood in patients with anorexia nervosa (AN). Grzelak et al reported that patients who suffer from AN are characterized by lower levels of NPB in the circulation compared to healthy controls, suggesting the use of NPB in diagnosing AN [ 36 ]. Nevertheless, as pointed out in this work, NPB levels were evaluated in only 30 healthy controls and 46 patients with anorexia [ 36 ]; therefore, these results should be interpreted cautiously.…”

Section: The Role Of Npb In Appetite Modulationmentioning

confidence: 99%

“…Grzelak et al reported that patients who suffer from AN are characterized by lower levels of NPB in the circulation compared to healthy controls, suggesting the use of NPB in diagnosing AN [ 36 ]. Nevertheless, as pointed out in this work, NPB levels were evaluated in only 30 healthy controls and 46 patients with anorexia [ 36 ]; therefore, these results should be interpreted cautiously. The downregulation of circulating NPB levels in patients with anorexia was independently confirmed by a study of 30 healthy controls and 30 patients with AN [ 37 ].…”

Section: The Role Of Npb In Appetite Modulationmentioning

confidence: 99%

The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis

Wojciechowicz

Billert

Jasaszwili

et al. 2021

IJMS

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Neuropeptide B (NPB) is a peptide hormone that was initially described in 2002. In humans, the biological effects of NPB depend on the activation of two G protein-coupled receptors, NPBWR1 (GPR7) and NPBWR2 (GPR8), and, in rodents, NPBWR1. NPB and its receptors are expressed in the central nervous system (CNS) and in peripheral tissues. NPB is also present in the circulation. In the CNS, NPB modulates appetite, reproduction, pain, anxiety, and emotions. In the peripheral tissues, NPB controls secretion of adrenal hormones, pancreatic beta cells, and various functions of adipose tissue. Experimental downregulation of either NPB or NPBWR1 leads to adiposity. Here, we review the literature with regard to NPB-dependent control of metabolism and energy homeostasis.

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“…Some authors emphasise sexual dimorphism of SVC in adults and children. They show that sex is an independent predictor of circulating vaspin in diabetic, obese, and nondiabetic patients, SVC increases with sexual maturation in girls, vaspin secretion is conditioned by nutrition status, and there is significantly higher SVC in female teenagers with anorexia nervosa than in healthy girls and lower in girls with Turner syndrome [23][24][25]. SVC in children with chronic kidney disease is significantly lower than in healthy children [26].…”

Section: Introductionmentioning

confidence: 99%

Increased serum vaspin concentration in full-term neonates with early-onset infections

Wiśniewska-Ulfik¹,

Behrendt²,

Nawrat³

et al. 2019

polp

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Aim of the study: The evaluation of serum vaspin concentration (SVC) in full-term, appropriate for gestational age (AGA) neonates, according to their sex, gestational age, anthropometric parameters, type of delivery, birth asphyxia, and kind of infection. Material and methods: In 183 full-term neonates, 102 infected and 81 healthy, 108 male and 75 female, 119 born vaginally and 64 by caesarean section, SVC was measured in serum of peripheral venous blood by ELISA test between the third and seventh day of life. The study was approved by the Ethics Committee of the Medical University of Silesia in Katowice. The neonates were divided into two groups: group I-102 infected; and group II (control)-81 healthy full-term neonates from physiological pregnancies. Early-onset infection involved sepsis (24 cases), bilateral pneumonia (38 cases), urinary tract infection (24 cases), purulent omphalitis, dermatitis, purulent meningitis, and osteomyelitis. Results: In infected neonates the SVC ranged from 0.093 to 1.19 ng/ml, and in the control group from 0.018 to 0.580 ng/ml. It was stated that infected neonates have significantly (p < 0.002) higher SVC than healthy neonates. Septic neonates had the highest value, significantly higher than local infected neonates. We did not observe any differences between infected males and females, or between those born by caesarean section and those delivered vaginally. Healthy girls had significantly higher SVC than the healthy boys. No correlation was noted between SVC and anthropometric parameters in both healthy and infected neonates and between sex, birth asphyxia, and C-reactive protein value in infected babies. Conclusions: Early-onset infections, especially sepsis, increase SVC in full-term, AGA neonates independently of their sex, birth asphyxia, and type of delivery.

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Neuropeptide B and Vaspin as New Biomarkers in Anorexia Nervosa

Cited by 6 publications

References 43 publications

Neuropeptide�B stimulates insulin secretion and expression but not proliferation in rat insulin‑producing INS‑1E cells

Neuropeptide�B stimulates insulin secretion and expression but not proliferation in rat insulin‑producing INS‑1E cells

The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis

Increased serum vaspin concentration in full-term neonates with early-onset infections

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