Neuropathology of Kynurenine Pathway of Tryptophan Metabolism

Tutakhail, Abdulkarim; Boulet, Lysiane; Khabil, Sarah; Nazari, Qand Agha; Hamid, Hafiza; François, Clément

doi:10.1007/s40495-019-00208-2

Cited by 19 publications

(14 citation statements)

References 173 publications

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“…3 . For example, tryptophan-kynurenine metabolism modulates 5-HT as well as glutamate signalling [ 98 ], while disordered tryptophan-kynurenine metabolism together with a pro-inflammatory state and changes in regional brain DA levels, have been described in an animal model of schizophrenia [ 99 ]. Trace amines, also relevant when discussing the stress-inflammation cascade in psychosis ( review by Gainetdinov et al [ 100 ]) modulate inflammatory cytokine production in macrophages via actions on.…”

Section: The Association Between Stress Inflammation and Treatment Rmentioning

confidence: 99%

“…Tryptophan-kynurenine modulators , such as allopurinol, inhibit xanthine oxidase as well as tryptophan 2,3-dioxygenase (TDO), thereby modulating the formation of kynurenine and the depletion of tryptophan for 5-HT synthesis. The tryptophan-kynurenine pathway plays an important mediating role in inflammation-induced psychopathology [ 98 ]. An early report suggested that treatment with allopurinol, in combination with a chemically modified superoxide dismutase (a scavenger of O 2 ), improved the survival rate of influenza virus-infected mice [ 352 ].…”

Section: Adjunctive Psychotropic Treatments During Sars-cov-2 Infectimentioning

confidence: 99%

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The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment

Vuren

Steyn

Brink

et al. 2021

Biomedicine & Pharmacotherapy

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Section: The Association Between Stress Inflammation and Treatment Rmentioning

confidence: 99%

Section: Adjunctive Psychotropic Treatments During Sars-cov-2 Infectimentioning

confidence: 99%

The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment

Vuren

Steyn

Brink

et al. 2021

Biomedicine & Pharmacotherapy

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“…Limited numbers of these initiations elaborated clinical candidates and registered for the clinical trials at the national institute of health. The therapeutic usefulness of hIDO1 and TDO inhibitors extended to the treatment of depression, psychosis, cognitive problems, neurodegenerative diseases, [22] pain, [23] inflammation, and musculoskeletal diseases [24] via the serotonin and kynurenine metabolic pathways blockade [9,22e,25] …”

Section: Introductionmentioning

confidence: 99%

Structural Basis of Selective Human Indoleamine‐2,3‐dioxygenase 1 (hIDO1) Inhibition

Kassab

Mowafy

2021

ChemMedChem

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hIDO1 is a heme−dioxygenase overexpressed in the tumor microenvironment and is implicated in the survival of cancer cells. Metabolism of tryptophan to N‐formyl−kynurenine by hIDO1 leads to immune suppression to result in cancer cell immune escape. In this article, we discuss the discovery of selective hIDO1 inhibitors for therapeutic intervention that have been promoted to clinical trials and for which crystallographic structural information is available for the respective inhibitor−enzyme complex. The structural insights are based on the complex crystal structures and the relative biological data profiles. The structural basis of selective hIDO1 inhibition, as discussed herein, opens new avenues to the discovery of novel inhibitors with improved activity profiles, selectivity, and distinct structure frameworks.

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“…The visual exercise, through cortical re-arrangement and oscillatory feedback signaling between cranial motor nerves, brain stem, thalamus, hypothalamus, and motor cortex regulates local and cortical endothelium releasing factors including NO and BDNF (44-48). To conclude, regulating several reciprocal feedback mechanisms between neuronal and vascular interactions, including hormones (e.g., melatonin, irisin), biomolecules (e.g., No, and BDNF), organelles (e.g., mitochondria), axis (e.g., hypothalamus-pituitary-adrenal (PHA)), and systems (e.g., immune and metabolism), regular physical exercises or other progressive regulatory techniques including eye movement exercise and diaphragmatic breathing can alleviate pain processing in a migraine brain (49)(50)(51)(52)(53)(54).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Jogging, Eye Movement Exercises, and Diaphragmatic Breathing in Reducing Migraine Symptoms: A Randomized Controlled Trial

Rahimi

Alidoosti

Hassani

et al. 2021

Preprint

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Background: electrophysiological dysresponsiveness (ED) is apparent in a migraine brain. Various methods have been suggested to regulate ED, including electrochemical transduction or regulation of Nitric Oxide (NO) and Brain-Derived Neurotrophic Factor (BDNF), jogging, eye movement exercises, and diaphragmatic breathing.Objectives and methods: A three-group, double-blind, and randomized design with pre-test, post-test, and follow-up assessment was used to test the effectiveness of jogging, eye movement exercises, and diaphragmatic breathing in the treatment of patients with episodic migraine. International Classification of Headache Disorders 3rd edition (ICHD-3) was used to diagnose the migraine patients, who were randomly assigned to one of the three study groups to perform either 12 consecutive weeks of (a) jogging and eye movement exercises (n = 22) ;(b) jogging and diaphragmatic breathing (n = 19); or (c) treatment as usual (TAU), receiving prescribed medication (n = 22) group.Results: The results of a series of MANCOVA showed that, compared to the TAU group, patients in the two experimental groups showed significant reductions in the frequency, duration, and intensity of their episodic migraine attacks. Moreover, the frequency of menstrual cycle-dependent headache attacks and over the counter drugs use were reduced, and the quality of sleep and drinking water were improved at post-test and a 12-month follow-up.Conclusion: The results suggest that jogging and eye movement exercises or jogging and diaphragmatic breathing can be used as effective alternative interventions in the treatment of episodic migraine.Trial registration retrospectively: Ir.mums.fm.rec.1396.362

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Neuropathology of Kynurenine Pathway of Tryptophan Metabolism

Cited by 19 publications

References 173 publications

The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment

The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment

Structural Basis of Selective Human Indoleamine‐2,3‐dioxygenase 1 (hIDO1) Inhibition

Effectiveness of Jogging, Eye Movement Exercises, and Diaphragmatic Breathing in Reducing Migraine Symptoms: A Randomized Controlled Trial

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