Neuronal protective effects of focal ischemic pre- and/or postconditioning on the model of transient focal cerebral ischemia in rats

Taşkapılıoğlu, Mevlüt Özgür; Alkan, Tülin; Gören, Bülent; Türeyen, Kudret; Şahi̇n, Soner; Taşkapılıoğlu, Özlem; Korfalı, Ender

doi:10.1016/j.jocn.2008.07.077

Cited by 18 publications

(10 citation statements)

References 26 publications

(34 reference statements)

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“…It also promotes the remodeling of synapses in the hippocampus (Liu et al, 2011). Astrocytes play an important role in this process (Humm et al, 1998;Taskapiliogly et al, 2009) by synthesizing glial-derived neurotrophic factor, which is responsible for the increased survival of dopaminergic neurons and by promoting neuroplasticity (Senna et al, 2011;Henderson et al, 1994;Lin et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Effect of Exercise Prior or After Ischemia on the Density of Neurons and Astrocytes in the Brain of Rats

Damázio¹,

Melo²,

Lima³

et al. 2014

American Journal of Neuroscience

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The aim of this study was to analyse the density of astrocytes and neurons in the motor areas of the cortex, striatum and hippocampus of rats that performed exercise before or after cerebral ischemia. A total of 36 Wistar rats were separated into two groups: One that was subjected to Middle Cerebral Artery Occlusion (MCAO) and the other that underwent surgical access in the absence of ischemia. Both groups were subdivided into: Animals that underwent exercise prior to MCAO and sham surgery (AI and AC, n = 12); animals that underwent exercise after MCAO and sham surgery (DI and DC, n = 12); and animals that did not undergo exercise (SI and SC, n = 12). The brains of mice were sectioned and stained by the Nissl method for staining of neurons and the astrocytes were labeled by immunohistochemistry with glial fibrillary acidic protein. Physical training was conducted after the surgery for 6 weeks (30 min/day), 5 days per week. The animals exercised before cerebral ischemia showed greater density of neurons in the striatum, in the apex of the dentate gyrus of the hippocampus, in the motor cortex contra lateral to the lesion and more astrocytes in the motor cortex of the cerebral hemispheres compared with the untrained group (p<0.05). The density of neurons in the brain regions analysed remained unchanged in exercised animals from the fourth day after cerebral ischemia when compared with the sedentary group.

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Section: Introductionmentioning

confidence: 99%

Effect of Exercise Prior or After Ischemia on the Density of Neurons and Astrocytes in the Brain of Rats

Damázio¹,

Melo²,

Lima³

et al. 2014

American Journal of Neuroscience

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“…IPC developed by a brief time (2 min) of transient cerebral ischemia does not result in pyramidal neuronal death in the CA1 region in the gerbil, and the IPC protects CA1 pyramidal neurons from lethal transient ischemic damage following a subsequent longer duration (5 min) of transient cerebral ischemia. It has been reported that IPC generates neuronal tolerance to a subsequent longer or lethal period of ischemia [31,32], although the time and interval of IPC has been determined by many researchers [7,23,33]. In this study, IPC induced by 2 min transient ischemia protected the CA1 pyramidal neurons from lethal transient ischemic damage induced by 5 min transient ischemia.…”

Section: Discussionmentioning

confidence: 63%

Neuroprotection of Ischemic Preconditioning is Mediated by Anti-inflammatory, Not Pro-inflammatory, Cytokines in the Gerbil Hippocampus Induced by a Subsequent Lethal Transient Cerebral Ischemia

et al. 2015

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Ischemic preconditioning (IPC) induced by sublethal transient cerebral ischemia could reduce neuronal damage/death following a subsequent lethal transient cerebral ischemia. We, in this study, compared expressions of interleukin (IL)-2 and tumor necrosis factor (TNF)-α as pro-inflammatory cytokines, and IL-4 and IL-13 as anti-inflammatory cytokines in the gerbil hippocampal CA1 region between animals with lethal ischemia and ones with IPC followed by lethal ischemia. In the animals with lethal ischemia, pyramidal neurons in the stratum pyramidale (SP) of the hippocampal CA1 region were dead at 5 days post-ischemia; however, IPC protected the CA1 pyramidal neurons from lethal ischemic injury. Expressions of all cytokines were significantly decreased in the SP after lethal ischemia and hardly detected in the SP at 5 days post-ischemia because the CA1 pyramidal neurons were dead. IPC increased expressions of anti-inflammatory cytokines (IL-4 and IL-13) in the stratum pyramidale of the CA1 region following no lethal ischemia (sham-operation), and the increased expressions of IL-4 and IL-13 by IPC were continuously maintained is the SP of the CA1 region after lethal ischemia. However, pro-inflammatory cytokines (IL-2 and TNF-α) in the SP of the CA1 region were similar those in the sham-operated animals with IPC, and the IL-4 and IL-13 expressions in the SP were maintained after lethal ischemia. In conclusion, this study shows that anti-inflammatory cytokines significantly increased and longer maintained by IPC and this might be closely associated with neuroprotection after lethal transient cerebral ischemia.

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“…These findings demonstrate the protective effect of ischemic post-conditioning and are consistent with findings from previous studies. [17][18][19] Both ischemic pre-conditioning (I PreC) and I PostC have protective effects against cerebral ischemia reperfusion injury. [20][21][22] However, I PreC is impractical as a clinical protective treatment because the onset of cerebral ischemia is unpredictable.…”

Section: Discussionmentioning

confidence: 99%

The effect of ischemic post-conditioning on hippocampal cell apoptosis following global brain ischemia in rats

Zhang

Wang

Zhou

et al. 2012

Journal of Clinical Neuroscience

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Neuronal protective effects of focal ischemic pre- and/or postconditioning on the model of transient focal cerebral ischemia in rats

Cited by 18 publications

References 26 publications

Effect of Exercise Prior or After Ischemia on the Density of Neurons and Astrocytes in the Brain of Rats

Effect of Exercise Prior or After Ischemia on the Density of Neurons and Astrocytes in the Brain of Rats

Neuroprotection of Ischemic Preconditioning is Mediated by Anti-inflammatory, Not Pro-inflammatory, Cytokines in the Gerbil Hippocampus Induced by a Subsequent Lethal Transient Cerebral Ischemia

The effect of ischemic post-conditioning on hippocampal cell apoptosis following global brain ischemia in rats

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