2018
DOI: 10.1038/s41377-018-0103-0
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Abstract: Optical activation of neurons requires genetic manipulation or the use of chemical photoactivators with undesirable side effects. As a solution to these disadvantages, here, we demonstrate optically evoked neuronal activity in mouse cortical neurons in acute slices and in vivo by nonlinear excitation of gold nanoparticles. In addition, we use this approach to stimulate individual epitheliomuscular cells and evoke body contractions in Hydra vulgaris. To achieve this, we use a low-power pulsed near-infrared exci… Show more

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Cited by 22 publications
(21 citation statements)
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“…The AuNP‐targeted stimulation could further stimulate individual epitheliomuscular cells and trigger body contractions in Hydra Vulgaris. [ 69 ]…”
Section: Gold Nanomaterials For Single‐mode Phototherapymentioning
confidence: 99%
“…The AuNP‐targeted stimulation could further stimulate individual epitheliomuscular cells and trigger body contractions in Hydra Vulgaris. [ 69 ]…”
Section: Gold Nanomaterials For Single‐mode Phototherapymentioning
confidence: 99%
“…The photothermal effect of nanoparticles has been reported to successfully modulate neurons mainly in vitro 9,[11][12][13]17,[36][37][38][39][40] . Two potential stimulation mechanisms were proposed, one through the increase of temperature, with highest temperature often found in the range of 50 °C to 70 °C 17,38 , and another through an optocapacitive stimulation determined by the rate of temperature change [13][14][15] . In our work, excited by a 3-nanosecond pulsed laser, the maximum temperature rise on the PAN surface is 8 °C and temperature change is in the form of 10 spikes, each of which is less than 10 nanoseconds in duration, over 3 ms.…”
Section: Successful In Vivo Activation Through Pans Directly Injectedmentioning
confidence: 99%
“…These techniques allow simultaneous photoactivation of arbitrary sets of neurons within the 3D imaging volume of an optical microscope with high spatial and temporal resolution . Although gold nanorods can be tuned to absorb directly in the near infrared tissue window, second‐order nonlinear processes can also be exploited for nanoparticle‐enhanced nerve stimulation …”
Section: Light Delivery and Recordingmentioning
confidence: 99%