Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independentlyof BDNF

Fritzen, Sabrina; Schmitt, Angelika; Köth, Katharina; Sommer, Claudia; Lesch, Klaus‐Peter; Reif, Andreas

doi:10.1016/j.mcn.2007.02.021

Cited by 29 publications

(27 citation statements)

References 53 publications

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“…At least 3 isoforms of NO synthase (NOS) have been identified in the CNS, including endothelial (eNOS), neuronal (nNOS) and inducible (iNOS) forms (32,33). It has been reported that nNOS-knockout increases the survival rate of neuronal cells in the hippocampus (34). However, our results showed that the number of nNOS-positive cells in the mice fed the hard diet was significantly increased (Fig.…”

Section: Discussionmentioning

confidence: 54%

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Akazawa

Kitamura

Fujihara

et al. 2012

International Journal of Molecular Medicine

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Abstract. In this study, we examined the effect of forced mastication on neurogenesis in the hippocampal dentate gyrus (DG) of adult mice. Six-week-old mice were subjected to either a hard or normal diet for 13 weeks. They received a daily injection of bromodeoxyuridine (BrdU) for 12 consecutive days beginning at 14 weeks of age. The number of BrdU-positive cells in the DG was counted 1 day after and 5 weeks after the final BrdU injection. The number of BrdU-positive cells 1 day after injection did not differ between the 2 diet groups. However, the number of BrdU-positive cells in the group fed the hard diet was significantly increased 5 weeks after BrdU injection compared to the group fed the normal diet. The results of the Morris water maze test showed that mice fed a hard diet required significantly less time to reach the platform than the control mice when tested at 10 days. Moreover, mice in the group fed the hard diet spent significantly more time in the former platform area than the group fed the normal diet, indicating that hard diet feeding improved spatial memory compared to normal diet feeding. Real-time PCR analysis showed that the expression of glutamate receptor 1 mRNA was significantly increased in the group fed the hard diet compared with the group fed the normal diet. These results suggest that mastication increases the survival of adult neural stem cells in the hippocampal DG.

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Section: Discussionmentioning

confidence: 54%

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Akazawa

Kitamura

Fujihara

et al. 2012

International Journal of Molecular Medicine

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“…In contrast, NOS-I/-III double knockout had significantly decreased survival rates. These results suggested that NO predominantly inhibits the survival of newborn cells emphasizing the important role of the different NOS isoforms with respect to adult neurogenesis [115].…”

Section: Nitric Oxide In Autismmentioning

confidence: 86%

Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids

Das

2013

Nutrition

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“…In nNOSknockout mice, however, cerebral ischemia-induced NPC proliferation and survival of newly formed neurons is enhanced in the dentate gyrus (30). Since the focal cerebral ischemia produces an increase in the level of iNOS as well as a decrease in nNOS level in the hippocampus, it is thought that enhancement of neurogenesis following brain ischemia may be due to up-regulation of iNOS after the decrease in nNOS in the hippocampus.…”

Section: Rosmentioning

confidence: 99%

Adult Neurogenesis Is Regulated by Endogenous Factors Produced During Neurodegeneration

et al. 2011

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Abstract. Adult neurogenesis is the process of generating new neurons that become integrated into existing circuits after fetal and early postnatal development has ceased. In most mammalian species, adult neurogenesis only appears to occur in the olfactory bulb and the hippocampus, where neural stem/progenitor cells (NPCs) exist to create new neurons. In adult neurogenesis, microenviromental change is thought to provide a specific modulation for maintaining the multi-potent state of these NPCs. Neurodegeneration is driven by the activation of resident microglia, astrocytes, and infiltrating peripheral macrophages, which release a plethora of cytokines, chemokines, neurotransmitters, and reactive oxygen species. These endogenous factors cause further bystander damage to neurons and produces both detrimental and favorable conditions for neurogenesis. Interestingly, these endogenous factors also affect the proliferation, migration, differentiation, and survival of the NPCs, as well as regulate the incorporation of newly formed neurons into the brain circuitry. The unique profile of the endogenous factors released can vary the degree of neuroregeneration after neurodegeneration. This current review summarizes recent knowledge in the emerging field that is showing that adult neurogenesis is regulated by endogenous factors produced during neurodegeneration.

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Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independentlyof BDNF

Cited by 29 publications

References 53 publications

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids

Adult Neurogenesis Is Regulated by Endogenous Factors Produced During Neurodegeneration

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