Neuronal Mitophagy in Neurodegenerative Diseases

Martínez-Vicente, Marta

doi:10.3389/fnmol.2017.00064

Cited by 158 publications

(123 citation statements)

References 131 publications

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“…68 In mammals, mitochondrial receptor proteins are divided into two categories based on locations: the receptor/adaptor proteins in the cytoplasm (p62, NDP52, Optneriun, TAX1BP, NBR1) and the transmembrane receptor proteins in the mitochondrial membrane (Nix, FUNDC1, BNIP3, and Bcl2-L-13). 60,[69][70][71][72][73][74][75] PINK1/Parkin-induced mitophagy, in which Parkin acts as the amplifier for PINK1-generated phospho-ubiquitin signals, is the best-studied pathway. 70,76 ATM is responsible for mitochondrial homeostasis by negatively regulating mitophagy.…”

Section: Atm In Mitophagymentioning

confidence: 99%

Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy

Liang

Liu

et al. 2019

Cell Biochemistry & Function

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The ataxia-telangiectasia mutated (ATM) protein kinase is best known for its critical nuclear roles in the DNA damage response (DDR), cell cycle checkpoints, and the maintenance of gene stability. In this review, we highlight the multifaceted cytoplasmic functions of ATM in autophagy. We focused on the functions of ATM in nonselective autophagy in cancer. An Oncomine database analysis showed a tight association between ATM and autophagy in various cancers. In particular, its mechanisms in nonselective autophagy, those induced by ionizing radiation (IR), are illustrated in detail and involve the MAPK14 pathway, mTOR pathway, and Beclin1/PI3KIII complexes. Recently, an increasing number of studies revealed that autophagy could also be highly selective. We additionally emphasized the novel roles of ATM in selective autophagy, including mitophagy, pexophagy, and lipophagy. The regulation of these processes mainly involves ATM-PEX5, ATM-AMPK-TSC2-mTORC1-ULK1, PPM1D-ATM-MTOR, PINK I/Parkin, and NAD+/ SIRT1. We aimed to provide new perspectives on the importance of ATM in the diverse field of autophagy. The intricate regulation of ATM in autophagy still requires further investigation, which would enhance our understanding of its role in cell dynamics and homeostasis.Significance of the study Our review highlighted the multifaceted cytoplasmic functions of ATM on autophagy. First, we focused on the functions of ATM in nonselective autophagy within cancer especially those induced by IR, involving the MAPK14 pathway, mTOR pathway, and Beclin1/PI3KIII complexes. These provided a theoretical understanding of tumour radiosensitivity and chemosensitivity. In addition, we emphasized the novel roles of ATM in selective autophagy, including mitophagy, pexophagy, and lipophagy. This review provides new perspectives on the importance of ATM in the diverse field of autophagy, which would provide more information on its role in whole cell dynamics and homeostasis.

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Section: Atm In Mitophagymentioning

confidence: 99%

Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy

Liang

Liu

et al. 2019

Cell Biochemistry & Function

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“…loss of membrane potential, or mtDNA damage) while preventing death via apoptosis pathways. Further details of mitophagy were recently reviewed by others (Hamacher-Brady and Brady, 2016; Martinez-Vicente, 2017). …”

Section: Mitochondrial Turnovermentioning

confidence: 99%

Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins

Aouacheria

Baghdiguian

Lamb

et al. 2017

Neurochemistry International

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The morphology of a population of mitochondria is the result of several interacting dynamical phenomena, including fission, fusion, movement, elimination and biogenesis. Each of these phenomena is controlled by underlying molecular machinery, and when defective can cause disease. New understanding of the relationships between form and function of mitochondria in health and disease is beginning to be unraveled on several fronts. Studies in mammals and model organisms have revealed that mitochondrial morphology, dynamics and function appear to be subject to regulation by the same proteins that regulate apoptotic cell death. One protein family that influences mitochondrial dynamics in both healthy and dying cells is the Bcl-2 protein family. Connecting mitochondrial dynamics with life-death pathway forks may arise from the intersection of Bcl-2 family proteins with the proteins and lipids that determine mitochondrial shape and function. Bcl-2 family proteins also have multifaceted influences on cells and mitochondria, including calcium handling, autophagy and energetics, as well as the subcellular localization of mitochondrial organelles to neuronal synapses. The remarkable range of physical or functional interactions by Bcl-2 family proteins is challenging to assimilate into a cohesive understanding. Most of their effects may be distinct from their direct roles in apoptotic cell death and are particularly apparent in the nervous system. Dual roles in mitochondrial dynamics and cell death extend beyond BCL-2 family proteins. In this review, we discuss many processes that govern mitochondrial structure and function in health and disease, and how Bcl-2 family proteins integrate into some of these processes.

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“…N ≥ 3 animals/genotype. Increased autophagy and mitophagy have been shown to exert protective effects in MDs and in other neurodegenerative diseases (Decressac et al, 2013;Martinez-Vicente, 2017). Of note, Parkin is one of the main players in the clearance of damaged mitochondria via the autophagy pathway (Geisler et al, 2010;Vives-Bauza et al, 2010).…”

mentioning

confidence: 99%

miR‐181a/b downregulation exerts a protective action on mitochondrial disease models

et al. 2019

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Mitochondrial diseases ( MD s) are a heterogeneous group of devastating and often fatal disorders due to defective oxidative phosphorylation. Despite the recent advances in mitochondrial medicine, effective therapies are still not available for these conditions. Here, we demonstrate that the micro RNA s miR‐181a and miR‐181b (miR‐181a/b) regulate key genes involved in mitochondrial biogenesis and function and that downregulation of these mi RNA s enhances mitochondrial turnover in the retina through the coordinated activation of mitochondrial biogenesis and mitophagy. We thus tested the effect of miR‐181a/b inactivation in different animal models of MD s, such as microphthalmia with linear skin lesions and Leber's hereditary optic neuropathy. We found that miR‐181a/b downregulation strongly protects retinal neurons from cell death and significantly ameliorates the disease phenotype in all tested models. Altogether, our results demonstrate that miR‐181a/b regulate mitochondrial homeostasis and that these mi RNA s may be effective gene‐independent therapeutic targets for MD s characterized by neuronal degeneration.

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Neuronal Mitophagy in Neurodegenerative Diseases

Cited by 158 publications

References 131 publications

Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy

Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy

Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins

miR‐181a/b downregulation exerts a protective action on mitochondrial disease models

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