Abstract:For both AD and PD the greatest neuronal loss was found in the LC. In AD, neuronal loss was most severe and best correlated with the duration of illness in the LC, rather than in NB as traditionally expected. Correlations between neuronal loss in the LC and NB (but not SN) in both PD and AD suggest that the former 2 nuclei may share common pathogenetic susceptibilities. Given the prominent loss of neurons in the LC, detection and treatment of noradrenergic deficiencies warrant attention in both AD and PD.
Smart CitationsHow this paper cites the one you are viewing
“…The LC-hippocampal connection was the most severely altered of all neural pathways examined in the 5XFAD mice (Fig. 9 a, t = 20.19, p < 0.0001), which supports previous reports of neuronal loss in the LC being most severe in patients with AD [ 51 ]. Fig.…”
Smart CitationsHow this paper cites the one you are viewing
“…The LC-hippocampal connection was the most severely altered of all neural pathways examined in the 5XFAD mice (Fig. 9 a, t = 20.19, p < 0.0001), which supports previous reports of neuronal loss in the LC being most severe in patients with AD [ 51 ]. Fig.…”
Smart CitationsHow this paper cites the one you are viewing
“…These findings suggest that the degeneration in extrastriatal monoaminergic structures in PD occurs independently from nigrostriatal degeneration and at a slower rate. These results are in line with several postmortem studies, which have shown that in advanced PD cases, the cell loss in non-dopaminergic nuclei ranges between 30 and 50%, whereas it is close to 80% in the nigral region (Jellinger, 1991;Zarow et al, 2003;Thannickal et al, 2007).…”
Smart CitationsHow this paper cites the one you are viewing
“…The reduction of mean LC CNR MTw in PD confirms previous MRI studies performed at high field strength and has also been shown in patients with RBD who are at high risk of developing PD 11,15,16,20,22,38 . This robust and replicable reduction of LC contrast on neuromelanin‐sensitive MRI images provides an in vivo indication of the loss of pigmented LC neurons demonstrated in postmortem histological studies 10,39‐41 . In our study as well as previous neuroimaging studies, the attenuation of CNR MTw did not correlate with disease duration or motor severity.…”
Smart CitationsHow this paper cites the one you are viewing
“…The LC-hippocampal connection was the most severely altered of all neural pathways examined in the 5XFAD mice (Fig. 9 a, t = 20.19, p < 0.0001), which supports previous reports of neuronal loss in the LC being most severe in patients with AD [ 51 ]. Fig.…”
Smart CitationsHow this paper cites the one you are viewing
“…These findings suggest that the degeneration in extrastriatal monoaminergic structures in PD occurs independently from nigrostriatal degeneration and at a slower rate. These results are in line with several postmortem studies, which have shown that in advanced PD cases, the cell loss in non-dopaminergic nuclei ranges between 30 and 50%, whereas it is close to 80% in the nigral region (Jellinger, 1991;Zarow et al, 2003;Thannickal et al, 2007).…”
Smart CitationsHow this paper cites the one you are viewing
“…The reduction of mean LC CNR MTw in PD confirms previous MRI studies performed at high field strength and has also been shown in patients with RBD who are at high risk of developing PD 11,15,16,20,22,38 . This robust and replicable reduction of LC contrast on neuromelanin‐sensitive MRI images provides an in vivo indication of the loss of pigmented LC neurons demonstrated in postmortem histological studies 10,39‐41 . In our study as well as previous neuroimaging studies, the attenuation of CNR MTw did not correlate with disease duration or motor severity.…”
Smart CitationsHow this paper cites the one you are viewing
“…The LC-hippocampal connection was the most severely altered of all neural pathways examined in the 5XFAD mice (Fig. 9 a, t = 20.19, p < 0.0001), which supports previous reports of neuronal loss in the LC being most severe in patients with AD [ 51 ]. Fig.…”
Smart CitationsHow this paper cites the one you are viewing
“…These findings suggest that the degeneration in extrastriatal monoaminergic structures in PD occurs independently from nigrostriatal degeneration and at a slower rate. These results are in line with several postmortem studies, which have shown that in advanced PD cases, the cell loss in non-dopaminergic nuclei ranges between 30 and 50%, whereas it is close to 80% in the nigral region (Jellinger, 1991;Zarow et al, 2003;Thannickal et al, 2007).…”
Smart CitationsHow this paper cites the one you are viewing
“…The reduction of mean LC CNR MTw in PD confirms previous MRI studies performed at high field strength and has also been shown in patients with RBD who are at high risk of developing PD 11,15,16,20,22,38 . This robust and replicable reduction of LC contrast on neuromelanin‐sensitive MRI images provides an in vivo indication of the loss of pigmented LC neurons demonstrated in postmortem histological studies 10,39‐41 . In our study as well as previous neuroimaging studies, the attenuation of CNR MTw did not correlate with disease duration or motor severity.…”
