Neuronal hypertrophy and mast cells in histologically negative, clinically diagnosed acute appendicitis: a quantitative immunophenotypical analysis

Amber, Safeena; Mathai, Alka Mary; Naik, Ramadas; Pai, Muktha R; Kumar, Suneet; Prasad, Keerthana

doi:10.1007/s12664-010-0016-1

Cited by 12 publications

(6 citation statements)

References 7 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[14] Remaining two cases showed mucosal neuronal hyperplasia and one showed myenteric neuronal hyperplasia. These cases also had increased number of neutrophils similar to the study by Amber et al [15] Giant cell reaction was found in three cases. One case was associated with transmural inflammation though there was no other evidence of Crohn's disease.…”

Section: Shift To Left 1 Total 10 Rif: Right Iliac Fossasupporting

confidence: 87%

A Retrospective Study of Histopathological Features of Appendectomy Specimens – What All can Expect?

Sinha¹,

Dey²

2016

JMSH

View full text Add to dashboard Cite

Introduction: Acute appendicitis is the most common cause of acute abdomen in young adults. It is also one of the most common conditions requiring emergency surgery. Macroscopically normal-appearing appendix, removed from patients with suspected acute appendicitis, on histopathological examination may reveal a more sinister underlying pathology. We did a retrospective study of the histopathological examination of 140 specimens of appendix to see the pattern of various findings. Materials and Methods: Hospital records of 140 patients who were diagnosed as acute appendicitis or recurrent acute appendicitis and who underwent appendectomy, either laparoscopic or open, were reviewed. Histopathology records of these resected appendices submitted to the

show abstract

Section: Shift To Left 1 Total 10 Rif: Right Iliac Fossasupporting

confidence: 87%

A Retrospective Study of Histopathological Features of Appendectomy Specimens – What All can Expect?

Sinha¹,

Dey²

2016

JMSH

View full text Add to dashboard Cite

show abstract

“…In about 20-25% of appendicectomies performed for clinically suspected acute appendicitis, definite morphological changes are lacking on histopathological examination. 1 Since appendectomy relieves pain, an unknown pathology is likely to exist. 2 The role of inflammatory reactions involving local endocrine cells and neuroproliferation in causing repeated attacks of pain has been described and several staining techniques including immunohistochemistry have been tried in detecting the pro-inflammatory mediators.…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

A Study of Mast Cells in Surgically Resected Appendix.

Verma¹,

R.M²,

R.M³

et al. 2016

IJAR

View full text Add to dashboard Cite

“…Although several studies have focused on the presence of neuronal hyperplasia/ hypertrophy (eg, increased numbers of ganglion cells) in the setting of clinical or histologically confirmed acute appendicitis, 1-3 none of these have demonstrated a predominance of swollen ganglion cells in small clusters or as single cells infiltrating the mucosa and superficial submucosa. As such, the current study is the first to highlight neuronal (ganglion cell) hyperplasia as a diagnostic pitfall in the differential diagnosis of goblet cell adenocarcinoma and signet-ring cell adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Acute Appendicitis with Neuronal Hyperplasia and Swelling: A Novel Histologic Mimic of Appendiceal Goblet Cell Adenocarcinoma and Signet-Ring Cell Adenocarcinoma

2021

View full text Add to dashboard Cite

Goblet cell adenocarcinoma and signet-ring cell adenocarcinoma are well-known diagnostic pitfalls of routine appendectomy specimens. Here we present a case of acute appendicitis with prominent neuronal (ganglion cell) hyperplasia and swelling which histologically mimics goblet cell adenocarcinoma and signet-ring cell adenocarcinoma. Attention to the cytologic features of the lesional cells (absence of atypia, mitotic activity) and their close association with nerves and classic ganglion cells, along with the use of a limited panel of immunostains, ensures proper classification of this rare but striking benign process.

show abstract

Neuronal hypertrophy and mast cells in histologically negative, clinically diagnosed acute appendicitis: a quantitative immunophenotypical analysis

Abstract: Neuronal hypertrophy and mast cells may play a role in the pathogenesis of appendicitis-like pain in patients with histologically normal appendices.

Cited by 12 publications

References 7 publications

A Retrospective Study of Histopathological Features of Appendectomy Specimens – What All can Expect?

A Retrospective Study of Histopathological Features of Appendectomy Specimens – What All can Expect?

A Study of Mast Cells in Surgically Resected Appendix.

Acute Appendicitis with Neuronal Hyperplasia and Swelling: A Novel Histologic Mimic of Appendiceal Goblet Cell Adenocarcinoma and Signet-Ring Cell Adenocarcinoma

Contact Info

Product

Resources

About