volume 27, issue 3, P651-664 2011
DOI: 10.3233/jad-2011-110590
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Cristina Cecchi, Elisa Evangelisti, Roberta Cascella, Mariagioia Zampagni, Susanna Benvenuti, Paola Luciani, Cristiana Deledda, Ilaria Cellai, Daniel Wright, Riccardo Saccardi, Alessandro Peri, Massimo Stefani

Abstract: Cell therapy is a promising approach for the treatment of neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. However, the presence of toxic aggregates in tissue raises the question of whether grafted stem cells are susceptible to amyloid toxicity before they differentiate into mature neurons. To address this question, we investigated the relative vulnerability of human mesenchymal stromal cells and their neuronally differentiated counterparts to Aβ(42) oligomers and whether susceptibili…

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