volume 25, issue 1, P119-133 2011
DOI: 10.3233/jad-2011-102025
View full text
|
|
Share
Sarah D. Schlatterer, Matthew A. Tremblay, Christopher M. Acker, Peter Davies

Abstract: Several immunocytochemical studies have revealed that Abelson tyrosine kinase (c-Abl) is associated with both neuritic plaques and neurofibrillary tangles in the brains of patients with Alzheimer’s disease (AD). Additionally, c-Abl has been shown to phosphorylate tau on tyrosine 394. The activity of c-Abl is also involved in the control of the cell cycle and apoptosis. To examine the consequences of c-Abl activation in the adult brain, we have constructed two lines of transgenic mice expressing either a const…

expand abstract