Neuron-specific enolase correlates with other prognostic markers after cardiac arrest

Abstract

NSE correlates well with other markers of ischemic brain injury. In patients with no other signs of brain injury, postanoxic ESE may explain a poor outcome.

Early prediction of coma recovery after cardiac arrest with blinded pupillometry

“…Serum NSE is a robust marker of postanoxic brain damage. A relationship between NSE and EEG findings has been previously reported by our group and others in comatose CA patients . Here, we are the first to describe a significant correlation between elevated NSE and reduced quantitative PLR.…”

Early prediction of coma recovery after cardiac arrest with blinded pupillometry

“…Serum NSE is a robust marker of postanoxic brain damage. A relationship between NSE and EEG findings has been previously reported by our group and others in comatose CA patients . Here, we are the first to describe a significant correlation between elevated NSE and reduced quantitative PLR.…”

Neurological prognostication after cardiac arrest and targeted temperature management 33°C versus 36°C: Results from a randomised controlled clinical trial

“…6,[8][9][10]12,21,32 Importantly our study confirms that a GCS M ≤2 is an unreliable marker of a poor prognosis in comatose patients. Furthermore the false positive rate of these findings remains high beyond 72 h after cardiac arrest.…”

Electroencephalography (EEG) for neurological prognostication after cardiac arrest and targeted temperature management; rationale and study design

“…Earlier studies of hypothermia-treated patients found that approximately one third of patients are still comatose 3 days after rewarming [ 53 ] and we found the proportion of patients that had an EEG in the TTM-trial (n = 399, 42%) to be close to the expected. Thereby, the 399 EEGs are likely to compose a representative sample of EEGs performed for the purpose of prognostication.…”

Early prediction of coma recovery after cardiac arrest with blinded pupillometry

“…Serum NSE is a robust marker of postanoxic brain damage. A relationship between NSE and EEG findings has been previously reported by our group and others in comatose CA patients . Here, we are the first to describe a significant correlation between elevated NSE and reduced quantitative PLR.…”

Neurological prognostication after cardiac arrest and targeted temperature management 33°C versus 36°C: Results from a randomised controlled clinical trial

“…6,[8][9][10]12,21,32 Importantly our study confirms that a GCS M ≤2 is an unreliable marker of a poor prognosis in comatose patients. Furthermore the false positive rate of these findings remains high beyond 72 h after cardiac arrest.…”

Electroencephalography (EEG) for neurological prognostication after cardiac arrest and targeted temperature management; rationale and study design

“…Earlier studies of hypothermia-treated patients found that approximately one third of patients are still comatose 3 days after rewarming [ 53 ] and we found the proportion of patients that had an EEG in the TTM-trial (n = 399, 42%) to be close to the expected. Thereby, the 399 EEGs are likely to compose a representative sample of EEGs performed for the purpose of prognostication.…”

Early prediction of coma recovery after cardiac arrest with blinded pupillometry

“…Serum NSE is a robust marker of postanoxic brain damage. A relationship between NSE and EEG findings has been previously reported by our group and others in comatose CA patients . Here, we are the first to describe a significant correlation between elevated NSE and reduced quantitative PLR.…”

Neurological prognostication after cardiac arrest and targeted temperature management 33°C versus 36°C: Results from a randomised controlled clinical trial

“…6,[8][9][10]12,21,32 Importantly our study confirms that a GCS M ≤2 is an unreliable marker of a poor prognosis in comatose patients. Furthermore the false positive rate of these findings remains high beyond 72 h after cardiac arrest.…”

Electroencephalography (EEG) for neurological prognostication after cardiac arrest and targeted temperature management; rationale and study design

“…Earlier studies of hypothermia-treated patients found that approximately one third of patients are still comatose 3 days after rewarming [ 53 ] and we found the proportion of patients that had an EEG in the TTM-trial (n = 399, 42%) to be close to the expected. Thereby, the 399 EEGs are likely to compose a representative sample of EEGs performed for the purpose of prognostication.…”