Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury–Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells

Li, Jian; Ouyang, Qing; Chen, Cheng-wen; Chen, Qian-bo; Li, Xiangnan; Xiang, Zhenghua; Yuan, Hongbin

doi:10.1093/pm/pnw316

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…Furthermore, Wnt/ β-catenin signaling was also reported to be negatively regulated by PS1 [ 35 ]. ADAM10 was suggested to cleave E-cadherin, which is mainly expressed in satellite glial cells [ 36 ]. Our data from the FpClass PPI prediction tool indicate that ADAM10 might interact with E-cadherin and ADAM17 rather than the other secretases or APP.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin

Dursun

Gezen-Ak

2017

PLoS ONE

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Our recent study indicated that vitamin D and its receptors are important parts of the amyloid processing pathway in neurons. Yet the role of vitamin D receptor (VDR) in amyloid pathogenesis is complex and all regulations over the production of amyloid beta cannot be explained solely with the transcriptional regulatory properties of VDR. Given that we hypothesized that VDR might exist on the neuronal plasma membrane in close proximity with amyloid precursor protein (APP) and secretase complexes. The present study primarily focused on the localization of VDR in neurons and its interaction with amyloid pathology-related proteins. The localization of VDR on neuronal membranes and its co-localization with target proteins were investigated with cell surface staining followed by immunofluorescence labelling. The FpClass was used for protein-protein interaction prediction. Our results demonstrated the localization of VDR on the neuronal plasma membrane and the co-localization of VDR and APP or ADAM10 or Nicastrin and limited co-localization of VDR and PS1. E-cadherin interaction with APP or the γ-secretase complex may involve NOTCH1, NUMB, or FHL2, according to FpClass. This suggested complex might also include VDR, which greatly contributes to Ca+2 hemostasis with its ligand vitamin D. Consequently, we suggested that VDR might be a member of this complex also with its own non-genomic action and that it can regulate the APP processing pathway in this way in neurons.

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Section: Discussionmentioning

confidence: 99%

Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin

Dursun

Gezen-Ak

2017

PLoS ONE

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“…According to the results of this systematic review, inflammation decreases when NM is applied 10 days after CCI, as shown by the reduction of most inflammatory molecules. GFAP is a marker of activated satellite glial cells in PNS, which increases after CCI and nerve ligation in rodents (50,51). Substance P, IL-1β and TRPV1 also contribute to inflammatory responses related to rodent neuropathic pain (52)(53)(54)(55).…”

Section: Authormentioning

confidence: 99%

Peripheral and central changes induced by neural mobilization in animal models of neuropathic pain: a systematic review

Salniccia,

de Vidania,

Martinez-Caro

2024

Front. Neurol.

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IntroductionNeural mobilization (NM) is a physiotherapy technique involving the passive mobilization of limb nerve structures with the aim to attempt to restore normal movement and structural properties. In recent years, human studies have shown pain relief in various neuropathic diseases and other pathologies as a result of this technique. Improvement in the range of motion (ROM), muscle strength and endurance, limb function, and postural control were considered beneficial effects of NM. To determine which systems generate these effects, it is necessary to conduct studies using animal models. The objective of this study was to gather information on the physiological effects of NM on the peripheral and central nervous systems (PNS and CNS) in animal models.MethodsThe search was performed in Medline, Pubmed and Web of Science and included 8 studies according to the inclusion criteria.ResultsThe physiological effects found in the nervous system included the analgesic, particularly the endogenous opioid pathway, the inflammatory, by modulation of cytokines, and the immune system.ConclusionOn the basis of these results, we can conclude that NM physiologically modifies the peripheral and central nervous systems in animal models.

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Satellite glia activation in dorsal root ganglion contributes to mechanical allodynia after selective motor fiber injury in adult rats

Yuan

Liu

Xian

et al. 2020

Biomedicine & Pharmacotherapy

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Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury–Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells

Abstract: Our findings indicate that neuron-derived ADAM10 production stimulates peripheral nerve injury-induced neuropathic pain by cleaving E-cadherin in satellite glial cells.

Cited by 5 publications

References 33 publications

Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin

Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin

Peripheral and central changes induced by neural mobilization in animal models of neuropathic pain: a systematic review

Satellite glia activation in dorsal root ganglion contributes to mechanical allodynia after selective motor fiber injury in adult rats

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