Neuron Culture Systems: Astrocyte‐Encapsulated Hydrogel Microfibers Enhance Neuronal Circuit Generation (Adv. Healthcare Mater. 5/2020)

Abstract

In article number 1901072 by Insung S. Choi and co‐workers, a 3D neuron‐culture system is fabricated by encapsulating astrocytes (green in the picture) in alginate microfibers and culturing hippocampal neurons (orange) on the aligned microfibers. The astrocyte‐laden microfibers enhance neurite outgrowth and synaptic formation as well as controlling the outgrowth directionality, suggesting a cytotherapeutic platform for neural injuries. The image was designed by co‐authors Sol Han and Hyunwoo Choi.

Strategic Advances in Spatiotemporal Control of Bioinspired Phenolic Chemistries in Materials Science

“…Reproduced with permission. [ 116 ] Copyright 2020, Wiley. e) Organic molecules or polymers (hyaluronic acid (HA), poly(ethylene glycol) (PEG), poly(vinyl alcohol) (PVA), poly( N ‐vinyl pyrrolidone) (PVP), polyethyleneimine (PEI), poly(allylamine hydrochloride) (PAH), poly(acrylic acid) (PAA), poly(styrene sulfonate) (PSS), poly(sulfobetaine methacrylate) (PSBMA), poly(methacryloyloxyethyl phosphorylcholine) (PMPC), pyrogallol (PG)).…”

“…[ 115 ] More importantly, the ultrafast and localized deposition of PDA at the target catalytic sites can lead to biosensors with enhanced sensitivity in biological detection and highly concentrated colorimetric signal for spatial biomarker labeling (Figure 4C, d). [ 115–116 ] Furthermore, organic molecules, including folic acid, [ 36 ] amino acids, [ 117 ] pyridine, [ 118 ] hexamethylenediamine, [ 119,120 ] and polymers [ 121 ] (e.g., polycations, polyanions, nonionic polymers, polysaccharides) are all potent additives to tailor the structures and properties of PDA for desired utilities (Figure 4C, e).…”