Neuromyelitis Optica Spectrum Disorder Treatment—Current and Future Prospects

Waliszewska‐Prosół, Marta; Chojdak-Łukasiewicz, Justyna; Budrewićz, Sławomir; Pokryszko−Dragan, Anna

doi:10.3390/ijms22062801

Cited by 18 publications

(17 citation statements)

References 91 publications

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“…However, the difference is that health insurance coverage is wider in foreign countries ( 16 ). At present, there is no existing effective treatment for NMOSD, and prevention of relapse is the principal goal of therapy ( 17 , 18 ). In our study, immunosuppressants and corticosteroids were the two most commonly prescribed drugs ( 19 ), and only a small proportion of patients used monoclonal antibodies.…”

Section: Discussionmentioning

confidence: 99%

Neuromyelitis optica spectrum disorder in Western China impacts employment and increases financial burden in women

Han

Hong²,

Yang³

et al. 2022

Front. Neurol.

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BackgroundNeuromyelitis optica spectrum disorder (NMOSD) often leads to disability and exerts a heavy toll on the work and life of affected female patients. This study aimed to analyze the current employment situation and economic burden as well as the risk factors for unemployment in female patients with NMSOD.MethodsWe compared the following unemployment- and employment-related aspects in with NSMOD, which were investigated using questionnaires: the specific impact of NMOSD on work, medical expenses, and factors affecting unemployment.ResultsWe enrolled 351 female patients with NMOSD. More than half (54.1%, 190/351) of participants reported that the disease led to unemployment. The unemployment group was significantly older (46.9 ± 12.1 years vs. 39.3 ± 9.4 years, P = 0.000), had a higher annual recurrence rate (ARR) (0.6 [inter quartile range [IQR]:0.4–0.9] vs. 0.5 [IQR: 0.3–0.8], P = 0.141), and a higher severe disability rate (44.2% vs. 11.2%, P = 0.000) than the employment group. Moreover, unemployed patients had lower education levels. The factors influencing unemployment included low education (junior middle-school or below), age, higher ARR, and severe disability (odds ratio [OR] = 6.943, P = 0.000; OR = 1.034, P = 0.010; OR = 1.778, P = 0.038; and OR = 4.972, P = 0.000, respectively). Medication and hospitalization costs constituted the principal economic burdens.ConclusionThe heavy financial burden, employment difficulties, and high unemployment rate are the most prominent concerns of female patients with NMOSD who require more social support and concern.

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Section: Discussionmentioning

confidence: 99%

Neuromyelitis optica spectrum disorder in Western China impacts employment and increases financial burden in women

Han

Hong²,

Yang³

et al. 2022

Front. Neurol.

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“…Autoantibody biomarkers are an indispensable clinical tool for this purpose. 1 , 2 , 3 , 4 , 5 , 6 Use of autoantibody biomarkers in human medicine includes screening markers to predict disease onset, 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 diagnostic markers to confirm disease identity, 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 and prognostic markers to characterize disease progression, 25 , 26 , 27 , 28 severity, 29 , 30 , 31 , 32 , 33 , 34 , 35 or response to treatment. 36 , 37 , 38 , 39 Autoantibody biomarkers in veterinary medicine mainly are limited to diagnostic use, and less often are used in monitoring disease progression or response to treatment.…”

Section: Introductionmentioning

confidence: 99%

A scoping review of autoantibodies as biomarkers for canine autoimmune disease

Treeful

Coffey

Friedenberg

2022

Veterinary Internal Medicne

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Background Autoantibody biomarkers are valuable tools used to diagnose and manage autoimmune diseases in dogs. However, prior publications have raised concerns over a lack of standardization and sufficient validation for the use of biomarkers in veterinary medicine. Objectives Systematically compile primary research on autoantibody biomarkers for autoimmune disease in dogs, summarize their methodological features, and evaluate their quality; synthesize data supporting their use into a resource for veterinarians and researchers. Animals Not used. Methods Five indices were searched to identify studies for evaluation: PubMed, CAB Abstracts, Web of Science, Agricola, and SCOPUS. Two independent reviewers (AET and ELC) screened titles and abstracts for exclusion criteria followed by full‐text review of remaining articles. Relevant studies were classified based on study objectives (biomarker, epitope, technique). Data on study characteristics and outcomes were synthesized in independent data tables for each classification. Results Ninety‐two studies qualified for final analysis (n = 49 biomarker, n = 9 epitope, and n = 34 technique studies). A high degree of heterogeneity in study characteristics and outcomes reporting was observed. Opportunities to strengthen future studies could include: (1) routine use of negative controls, (2) power analyses to inform sample sizes, (3) statistical analyses when appropriate, and (4) multiple detection techniques to confirm results. Conclusions These findings provide a resource that will allow veterinary clinicians to efficiently evaluate the evidence supporting the use of autoantibody biomarkers, along with the varied methodological approaches used in their development.

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“…Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system) and is characterized by injury to the optic nerve, spinal cord, brainstem, and/or brain parenchyma, which can cause severe visual dysfunction and ambulatory disability ( 1 , 2 ). The retina is one of the sites of inflammation as a result of blood-retinal barrier disruption in NMOSD.…”

Section: Introductionmentioning

confidence: 99%

Visual function and disability are associated with microcystic macular edema, macular and peripapillary vessel density in patients with neuromyelitis optica spectrum disorder

Chen

Zhang

et al. 2022

Front. Neurol.

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PurposeTo assess macular and peripapillary vessel density and neurodegeneration in eyes with and without microcystic macular edema (MME) in neuromyelitis optica spectrum disorder (NMOSD) patients while investigating their association with visual impairment and disease disability.MethodsThis is a cross-sectional study. A total of 52 eyes from 29 NMOSD patients were recruited, including 8 eyes with MME from 7 patients. Optical coherence tomography angiography (OCTA) images were analyzed to quantify the radial papillary capillary density (RPCD), and the density of macular microvascular network in both the superficial retinal capillary plexus (SRCP) and the deep retinal capillary plexus (DRCP). Thicknesses of the neural retinal layers centered on the fovea and the optic nerve head were also collected by OCT. Best-corrected visual acuity (BCVA) and Expanded Disability Status Scale (EDSS) scores were assessed for all patients. Microvascular densities and retinal sublayer thicknesses were compared among groups, and correlations of these vascular and structural parameters with BCVA and EDSS scores were determined.ResultsPatients with NMOSD and MME had significantly decreased visual acuity and worse EDSS score than patients without MME (P = 0.01 and 0.002, respectively). The vessel density in SRCP and RPCD were significantly lower in eyes with MME and ON compared to that of eyes with ON but without MME and eyes without MME or ON. Impairment of visual acuity and disease severity were significantly negatively associated with the reduction of SRCP vessel density and RPCD but were not related to DRCP vessel density.ConclusionsMME were correlated with worse visual impairment and disability in NMOSD patients. Sparse SRCP vessel density and RPCD were observed in NMOSD MME eyes and correlated with worse BCVA and EDSS scores.

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Neuromyelitis Optica Spectrum Disorder Treatment—Current and Future Prospects

Cited by 18 publications

References 91 publications

Neuromyelitis optica spectrum disorder in Western China impacts employment and increases financial burden in women

Neuromyelitis optica spectrum disorder in Western China impacts employment and increases financial burden in women

A scoping review of autoantibodies as biomarkers for canine autoimmune disease

Visual function and disability are associated with microcystic macular edema, macular and peripapillary vessel density in patients with neuromyelitis optica spectrum disorder

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