Neuromodulators of the lingual von Ebner gland: an immunocytochemical study

Solomon, Sidney; Brusco, O. A.; Goldberg, William J.; Bernstein, Jerald J.

doi:10.1007/bf00315986

Cited by 12 publications

(4 citation statements)

References 20 publications

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“…DISCUSSION Our experiments showed that SP stimulated secretion of both lingual lipase and amylase from von Ebner's gland in a doseand time-dependent manner. In addition, recent histochemical studies of rat von Ebner's glands revealed degranulation of acinar cells in response to SP (53) and the presence of SP immunoreactivity in selective cells (38) and neuronal elements (33).…”

Section: Resultsmentioning

confidence: 99%

Effect of Substance P and Receptor Antagonists on Secretion of Lingual Lipase and Amylase from Rat von Ebner's Gland

Field

Chirtel

Redman³

1997

Peptides

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Substance P (SP, 1 microM) when incubated with minced von Ebner's glands for 15, 30, and 60 min, stimulated secretion of lingual lipase (12.14% +/- 0.90) and amylase (8.30% +/- 0.42). Only 10 microM of the SP receptor antagonist CP-96,345 significantly inhibited SP-evoked secretion. D-Pro2-D-Phe7-D-Trp9-SP (Ia), D-Pro2-D-Trp7,9-SP (Ib), D-Arg1-D-Trp7,9-D-Leu11-SP (Ic), or 1 microM CP-96,345 were not effective, suggesting that the SP receptor of von Ebner's gland might be an isoform. Propranolol and timolol, beta 1/beta 2-adrenergic receptor antagonists were not effective and the cholinergic receptor antagonist, atropine, was effective in only slightly reducing amylase secretion but not lingual lipase. Differential secretion of the two enzymes was observed for basal and stimulated secretion. Thus, exocytosis may not be the only pathway involved in SP-evoked protein secretion.

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Section: Resultsmentioning

confidence: 99%

Effect of Substance P and Receptor Antagonists on Secretion of Lingual Lipase and Amylase from Rat von Ebner's Gland

Field

Chirtel

Redman³

1997

Peptides

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“…Somatostatin, substance P, and vasointestinal peptide (VIP) have been localized immunohistochemically to nerve fi bers serving VEG (Roberts et al 1991); substance P fi bers were observed to be in close contact with myoepithelial cells (Oomori et al 1995). In general, secretion is controlled primarily by cholinergic stimulation with contributions from β -adrenergic stimulation and enhancement by substance P (Hamosh 1978, Field and Hand 1987, Field et al 1989, Gurkan and Bradley 1988, Ruellan et al 1988, Ueba and Uchihashi 1991.…”

Section: Lingual Serous Glands Of Von Ebner (Veg)mentioning

confidence: 94%

Morphologic diversity of the minor salivary glands of the rat: fertile ground for studies in gene function and proteomics

Redman¹

2011

Biotechnic & Histochemistry

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In this article the locations and histologic and ultrastructural features of all of the minor salivary glands of the rat are presented; similarities and differences among them are highlighted. These glands are almost as diverse morphologically as the major salivary glands of the rat. The acini of von Ebner's glands are serous; those of the anterior and posterior buccal glands and minor sublingual glands are mucous; and those of the glossopalatal, palatal, and Weber's glands are mucous with serous demilunes. The anterior buccal, minor sublingual and von Ebner's glands have striated and stratified columnar ducts, while only the minor sublingual and von Ebner's glands have intercalated ducts. The glossopalatal, palatal, posterior buccal and Weber's glands have none of these ducts; the tubulo-acini drain abruptly into short terminal ducts composed of stratified squamous epithelium. All of the mucous acini react with an antibody to a mucin (Muc19) of the rat major sublingual gland, but in some of the glands the reaction varies in intensity among the acinar cells. Ultrastructurally, the mucous secretory granules of the anterior buccal, glossopalatal, palatal and Weber's glands are biphasic, while those of the minor sublingual and posterior buccal glands are monophasic. Although there is a considerable body of literature concerning the development, innervation, physiology and proteomics of von Ebner's glands, investigation of the other minor salivary glands of the rat ranges from modest to nearly nonexistent.

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“…There are approximately eight to 12 circumvallate papillae, located directly anterior to the terminal sulcus. The ducts of the lingual glands of von Ebner secrete lingual lipase into the surrounding troughs to begin the process of lipolysis [10]. On the lateral surface of the tongue foliate papillae are identified, they are small folds of mucosa.…”

Section: Tongue Anatomymentioning

confidence: 99%

Oral Tongue Cancer: Literature Review and Current Management

Arrangoiz¹,

Cordera²,

Caba³

et al. 2018

Cancer Rep Rev

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In 2018, it is estimated that about 51, 540 new cases of oral cavity and pharyngeal cancer will develop, which represent approximately 3-5% of all cancers in the United States. During the same time period it is estimated that there will be approximately 10, 030 deaths. Incidence rates are more than twice as high in men as in women (Male cases-37,160, Female cases-14,380). From 2006 to 2010 incidence rates remained stable in men and have decreased by 0.9% per year in women. Oral tongue cancer requires a multidisciplinary approach to treat it that includes a surgical oncologist, a medical oncologist, a radiation oncologist, speech therapists and physical rehabilitation as well as emotional support through the help of psychologists or social workers. In this review paper we will discuss current management of these complex tumor.

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Neuromodulators of the lingual von Ebner gland: an immunocytochemical study

Cited by 12 publications

References 20 publications

Effect of Substance P and Receptor Antagonists on Secretion of Lingual Lipase and Amylase from Rat von Ebner's Gland

Effect of Substance P and Receptor Antagonists on Secretion of Lingual Lipase and Amylase from Rat von Ebner's Gland

Morphologic diversity of the minor salivary glands of the rat: fertile ground for studies in gene function and proteomics

Oral Tongue Cancer: Literature Review and Current Management

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