Neurolymphomatose périphérique humaine (polyradiculonévrite réticuloendothéliosique)

Trelles, J. O.; Urquiaga, C.; Palomino, L.; Trelles, Luis

doi:10.1016/0022-510x(76)90102-7

“…edu) I nfiltration of the peripheral nervous system (PNS) 3 by lymphoma was termed "neurolymphomatosis" (NL) prior to identification of the causative B lymphocyte (Lhermitte and Trelles, 1934). The least common clinical presentation of nervous system lymphoma (Dickenman and Chason, 1958;Griffin et al 1971), malignant lymphocytic infiltrates of root, plexus, and nerve, is separable from nontumor disorders associated with lymphoma such as irradiation, chemotherapy, or paraneoplastic effects (Borit and Altrocchi, 1971;Kuroda et al, 1989;Schoenfeld et al, 1983;Trelles and Trelles, 1983;Trelles et al, 1976;Vallat et al, 1995).…”

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confidence: 99%

Neurolymphomatosis

Baehring¹

2003

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The term "neurolymphomatosis" (NL) has included infiltration of the peripheral nervous system by lymphoma and nontumor lymphocytes. We describe NL as a lymphoma entity that affects cranial and peripheral nerves and roots. We reviewed the medical records of patients at the Massachusetts General Hospital (MGH) who registered between 1972 and 2000, as well as cases published in the English-language literature. Inclusion criteria were (A) histopathologic demonstration of lymphoma within peripheral nerve, nerve root/plexus, or cranial nerve or (B) CT/MRI or intraoperative evidence of nerve enlargement and/or enhancement beyond the dural sleeve in the setting of prior or concurrent lymphoma in systemic or CNS sites. We identified 25 patients with NL in addition to 47 reported by others. Four clinical presentations were (1) painful involvement of nerves or roots, (2) cranial neuropathy with or without pain, (3) painless involvement of peripheral nerves, (4) painful or painless involvement of a single peripheral nerve. Twenty of our patients and 44 of those reported had histopathologic confirmation of lymphoma infiltrating root or nerve. In the remainder, diagnosis was based upon clinical presentation, nodular nerve enlargement or enhancement, and lymphoma cells in spinal fluid or extraneural sites. For antemortem diagnosis, imaging studies were of greatest utility, followed by biopsy. Thirty-three patients of the combined series were not correctly diagnosed until postmortem examination. Systemic chemotherapy was used to address the multiple potential sites of involvement. When properly treated, NL carries a prognosis similar to primary CNS lymphoma in the modern era.

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“…02-017, February 12, 2003 I nfiltration of the peripheral nervous system (PNS) 3 by lymphoma was termed "neurolymphomatosis" (NL) prior to identification of the causative B lymphocyte (Lhermitte and Trelles, 1934). The least common clinical presentation of nervous system lymphoma (Dickenman and Chason, 1958;Griffin et al 1971), malignant lymphocytic infiltrates of root, plexus, and nerve, is separable from nontumor disorders associated with lymphoma such as irradiation, chemotherapy, or paraneoplastic effects (Borit and Altrocchi, 1971;Kuroda et al, 1989;Schoenfeld et al, 1983;Trelles and Trelles, 1983;Trelles et al, 1976;Vallat et al, 1995).…”

mentioning

confidence: 99%

Neurolymphomatosis

Baehring¹,

Damek²,

Martin³

et al. 2003

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The term "neurolymphomatosis" (NL) has included infiltration of the peripheral nervous system by lymphoma and nontumor lymphocytes. We describe NL as a lymphoma entity that affects cranial and peripheral nerves and roots. We reviewed the medical records of patients at the Massachusetts General Hospital (MGH) who registered between 1972 and 2000, as well as cases published in the English-language literature. Inclusion criteria were (A) histopathologic demonstration of lymphoma within peripheral nerve, nerve root/plexus, or cranial nerve or (B) CT/MRI or intraoperative evidence of nerve enlargement and/or enhancement beyond the dural sleeve in the setting of prior or concurrent lymphoma in systemic or CNS sites. We identified 25 patients with NL in addition to 47 reported by others. Four clinical presentations were (1) painful involvement of nerves or roots, (2) cranial neuropathy with or without pain, (3) painless involvement of peripheral nerves, (4) painful or painless involvement of a single peripheral nerve. Twenty of our patients and 44 of those reported had histopathologic confirmation of lymphoma infiltrating root or nerve. In the remainder, diagnosis was based upon clinical presentation, nodular nerve enlargement or enhancement, and lymphoma cells in spinal fluid or extraneural sites. For antemortem diagnosis, imaging studies were of greatest utility, followed by biopsy. Thirty-three patients of the combined series were not correctly diagnosed until postmortem examination. Systemic chemotherapy was used to address the multiple potential sites of involvement. When properly treated, NL carries a prognosis similar to primary CNS lymphoma in the modern era.

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“…NL is an uncommon form of initial presentation or recurrence of lymphoma. It was described by Lhermitte and Trelles [8] in 1934 as a localized invasion of malignant lymphoid cells into peripheral nerves, roots, and cranial nerves. The nerve structures involved are peripheral nerves (60% of cases), spinal nerve roots (48% of cases), nerve plexus (40% of cases), cranial nerves (46% of cases), and multiple sites (58% of cases) [9].…”

Section: Discussionmentioning

confidence: 99%

Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness

Kim

¹

,

Kim

²

,

Rok

³

et al. 2021

Yeungnam Univ J Med

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Neurolymphomatosis (NL), defined as lymphocytic invasion of the peripheral nervous system in a hematologic malignancy setting, is a rare form of lymphoma that may occur as an initial presentation or recurrence [1]. Involvement of the peripheral nerves, spinal nerve roots, nerve plexus, cranial nerves, and multiple sites has been reported [2]. Since its characteristic symptoms vary according to the site of involvement, physicians might fail to obtain an accurate diagnosis. NL should be discriminated from other neuro-

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Neurolymphomatose périphérique humaine (polyradiculonévrite réticuloendothéliosique)

Cited by 13 publications

References 16 publications

Neurolymphomatosis

Neurolymphomatosis

Neurolymphomatosis

Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness

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