Neurological manifestations in HTLV-I-infected blood donors

Leite, Ana Cláudia Celestino Bezerra; Mendonça, Gulnar Azevedo Silva; Serpa, Maria José Andrada; Nascimento, Osvaldo J. M.; Araújo, Abelardo

doi:10.1016/s0022-510x(03)00179-5

Cited by 25 publications

(23 citation statements)

References 29 publications

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“…[6][7][8]13 However, all but one of the studies consisted of uncontrolled case reports, so results could not be appropriately compared with HTLV-seronegative persons. Because peripheral neuropathy has multiple causes, 35 the use of a control group is critical.…”

Section: Discussionmentioning

confidence: 99%

“…These symptoms and conditions may later progress to HAM or constitute isolated neurologic syndromes associated with HTLV infection. Sensory neuropathy, [6][7][8] gait abnormalities, 9,10 bladder dysfunction, 6,9-12 erectile dysfunction, 13,14 ALS, 15 mild cognitive deficits, 16 and rarely, motor neuropathies 6,8,13,[17][18][19] have all been reported among HTLV-I-infected individuals without HAM. Although less research has focused on HTLV-II, sensory neuropathy has been observed with HTLV-II alone 20 and with HIV coinfection.…”

mentioning

confidence: 99%

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Neurologic abnormalities in HTLV-I– and HTLV-II–infected individuals without overt myelopathy

Biswas

Engstrom²,

Kaidarova³

et al. 2009

Neurology

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Neurologic abnormalities in HTLV-I– and HTLV-II–infected individuals without overt myelopathy

Biswas

Engstrom²,

Kaidarova³

et al. 2009

Neurology

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“…Objective leg weakness is described in some studies and can reach a prevalence of 10% 6,78,81,91 . Some of those pyramidal signs appear as an isolated form and some combined with urinary and erectile dysfunction 80 , but not fulfilling the formal criteria for HAM/TSP. Interestingly in two cohort studies involving children with HTLV-1 a high prevalence of hyperreflexia was found and there was a strong relation with skin diseases (infective dermatitis, seborrhea, eczema) and anemia 79,90 .…”

Section: Isolated Pyramidal Signsmentioning

confidence: 94%

“…In the literature, hyperreflexia was found to be prevalent with a range from 4.6 to 34% 78 , Babinski sign was not common and has been seen in 6 to 10.4% [78][79][80][81]90 ( Table 2). Objective leg weakness is described in some studies and can reach a prevalence of 10% 6,78,81,91 .…”

Section: Isolated Pyramidal Signsmentioning

confidence: 99%

Immunopathogenesis and neurological manifestations associated to HTLV-1 infection

Souza¹,

Tanajura

Toledo-Cornell

et al. 2012

Rev. Soc. Bras. Med. Trop.

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The human T lymphotropic virus type-1 (HTLV-1) was the first human retrovirus identified. The virus is transmitted through sexual intercourse, blood transfusion, sharing of contaminated needles or syringes and from mother to child, mainly through breastfeeding. In addition to the well-known association between HTLV-1 and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), several diseases and neurologic manifestations have been associated with the virus. This review was conducted through a PubMed search of the terms HTLV-1, immune response and neurological diseases. Emphasis was given to the most recent data regarding pathogenesis and clinical manifestations of HTLV-1 infection. The aim of the review is to analyze the immune response and the variety of neurological manifestations associated to HTLV-1 infection. A total of 102 articles were reviewed. The literature shows that a large percentage of HTLV-1 infected individuals have others neurological symptoms than HAM/TSP. Increased understanding of these numerous others clinical manifestations associated to the virus than adult T cell leukemia/lymphoma (ATLL) and HAM/TSP has challenged the view that HTLV-1 is a low morbidity infection.

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“…HTLV-I carriers present with severe muscular atrophy, fasciculation, and pyramidal tract damage similar to those noted in amyotrophic lateral sclerosis (ALS) (8)(9)(10)(11). Silva et al (12) reported that 1.9% of HTLV-I carriers with neurological symptoms present with an ALS-like syndrome, which is unusual in typical HAM/TSP.…”

Section: Introductionmentioning

confidence: 91%

Fulminant Myelopathy following Neurogenic Proximal Weakness Associated with Human T-Cell Lymphotropic Virus Type I Infection

et al. 2011

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We report a patient with human T-cell lymphotropic virus type I (HTLV-I) infection, who presented with proximal extremity neurogenic muscular weakness followed by fulminant myelopathy, but with no upper motor symptoms. The symptoms were inconsistent with the World Health Organization or El Escorial criteria for HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) or amyotrophic lateral sclerosis (ALS). This case indicates that fulminant myelopathy without upper motor neuronal symptoms may occur long after the onset of HTLV-I-associated neurogenic proximal muscular weakness. Additionally, we report that treatment with high-dose steroid pulse therapy partially improves symptoms of lightning pain and sensory disturbance.

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Neurological manifestations in HTLV-I-infected blood donors

Cited by 25 publications

References 29 publications

Neurologic abnormalities in HTLV-I– and HTLV-II–infected individuals without overt myelopathy

Neurologic abnormalities in HTLV-I– and HTLV-II–infected individuals without overt myelopathy

Immunopathogenesis and neurological manifestations associated to HTLV-1 infection

Fulminant Myelopathy following Neurogenic Proximal Weakness Associated with Human T-Cell Lymphotropic Virus Type I Infection

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