Neurological disease in pregnancy

Mohan, Naina; Nelson‐Piercy, Catherine

doi:10.1016/j.ogrm.2021.11.003

Cited by 1 publication

(1 citation statement)

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“…Because myasthenic crises and mortality are more common in the first year or two following diagnosis, including in early pregnancy and after childbirth, deferring pregnancy until first year or two is common. Prior to actually conceiving, females with myasthenia gravis must consult with their neurologist to discuss the importance of thymectomy, maximize clinical benefits, and reduce the need of immunomodulatory medicines [16]. The therapy aims to reduce disease severity in the mother while reducing the potential harm to the fetus.…”

Section: Introductionmentioning

confidence: 99%

Overview of Myasthenia Gravis Subgroups and its influence on Pregnancy and their Treatment Advances

Wal¹,

Wal²,

Pandey³

et al. 2022

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Antibodies that attack the neuromuscular junction induce myasthenia gravis, an immunological illness. Such antibodies assault and degrade postsynaptic molecules in by binding to the postsynaptic muscular end-plate. As a consequence, signal transduction is disrupted, resulting in muscular weakness and fatigability. Developments in our knowledge of the immunological mechanisms that cause myasthenia gravis have paved the way for the development of new targeted immunity treatments. The majority of myasthenia gravis sufferers have a well-managed condition with just minor to moderate symptoms. The goal must be to create more targeted therapies that reduce or enhance tolerance to the well-known and particular autoimmune reactions that result in autoantibody formation and muscular weakening. Several drugs widely used in obstetrics can aggravate the condition. The impact of maternity on myasthenia varies greatly from one woman to the next, as well as from one pregnancy to the next within the same woman. Acetylcholine esterase inhibitors, corticosteroids, and other immunosuppressants, as well as proper rest, are the most common therapy. Intrauterine antibody exposure can cause in utero or neonatal effects in newborns, which are usually temporary. This review focuses on myasthenia gravis subgroups and treatment breakthroughs, as well as the influence of myasthenia gravis on pregnancy and its management.

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Section: Introductionmentioning

confidence: 99%