Neurological complications of celiac disease and autoimmune mechanisms: A prospective study

Briani, Chiara; Zara, Gabriella; Alaedini, Armin; Grassivaro, Francesca; Ruggero, Susanna; Toffanin, Elisabetta; Albergoni, Maria Paola; Luca, M.M.G. Di; Giometto, Bruno; Ermani, Mario; Lazzari, F. De; D’Odorico, Anna; Battistin, Leontino

doi:10.1016/j.jneuroim.2008.01.008

Cited by 109 publications

(97 citation statements)

References 21 publications

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“…79,82 Several of the above neurological disorders have been linked to poor QoL, [83][84][85] and we cannot rule out that psychological dimensions of neurological comorbidity have thereby influenced QoL in CD patients. Neurological and psychological morbidities in CD patients might be caused by the mechanisms reported above, such as vitamin deficiency and hyperhomocysteinemia, as well as by the presence of antineuronal antibodies 86 and brain dysfunctions. 87 For example, a similar gray matter loss described in particular in the gyrus rectus and anterior cingulate gyrus of CD patients with neurological disturbances 87 has also been reported in individuals with depression.…”

Section: Mechanisms Explaining Psychological Morbiditiesmentioning

confidence: 99%

Psychological morbidity of celiac disease: A review of the literature

et al. 2015

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Section: Mechanisms Explaining Psychological Morbiditiesmentioning

confidence: 99%

Psychological morbidity of celiac disease: A review of the literature

et al. 2015

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“…Some others reported this rate as 8-22.5% 11,12 . On the other hand, Luostarinen et al 13 reported that the underlying cause was CD in 7% of the patients presented with neurological findings.…”

Section: Discussionmentioning

confidence: 98%

Neurological findings spectrum in Celiac disease

et al. 2016

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We aimed to provide early diagnosis by determining possible Celiac disease related subclinical or symptomatic neurological abnormalities in children in order to decrease risk of mortality and morbidity.Children with Celiac disease were assessed with neurological examination, neurophysiological tests and neuroimaging.A total of 65 patients were included in the study. The neurological examination was abnormal in 4 patients. There were EEG abnormalities in 5 patients, VEP was abnormal in 7 patients, BAER was abnormal in 1 patient, ENMG was abnormal in 8 patients, and there were abnormal findings on neuroimaging in 2 patients.The Celiac disease related neurological complications that manifest in adulthood usually lay their foundations in childhood. Therefore, it must be kept in mind that subclinical neurological abnormalities may be related to Celiac disease, and Celiac disease may be the underlying cause in the patients with overt neurological abnormalities in childhood.

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“…In general. neurological manifestations including epilepsy, dementia, peripheral neuropathy and cerebellar ataxia are estimated to occur in 7-22.5% of CD cases (3,7,8).…”

Section: Discussionmentioning

confidence: 99%

Celiac Disease and Associated Neurological Conditions

IŞIKAY¹,

HIZLI²

2015

Turkish J Pediatr Dis

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Objective: Celiac disease has been associated with many neurological disorders. In this report, we discuss 16 patients with both celiac disease and neurological symptoms and evaluate the overall neurological features of celiac disease in the light of the current literature to emphasize the neurological aspects of celiac disease. Material and Methods:The medical records of all patients diagnosed with celiac disease between 2010 and 2012 were reviewed.Results: Nine of these 16 cases were female while seven were male with a mean age of 10.34±3.76 years (5-16 years). The reported neurological problems of these 16 children with celiac disease were epilepsy (n=10), mental retardation (n=9), ataxia (n=3), neuropathy (n=1), headache (n=2), febrile seizure (n=1), and neurofi bromatosis type 1 (plus headache) (n=1). Conclusion:Celiac disease may accompany many different neurological conditions. These disorders can share some symptoms such as associated anemia, short stature, and chronic gastrointestinal complaints and the diagnosis of celiac disease may be delayed among patients with neurological disease.

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Neurological complications of celiac disease and autoimmune mechanisms: A prospective study

Cited by 109 publications

References 21 publications

Psychological morbidity of celiac disease: A review of the literature

Psychological morbidity of celiac disease: A review of the literature

Neurological findings spectrum in Celiac disease

Celiac Disease and Associated Neurological Conditions

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