Neuroimaging Intermediate Phenotypes of Executive Control Dysfunction in Schizophrenia

Sutcliffe, Grant; Harneit, Anais; Tost, Heike; Meyer‐Lindenberg, Andreas

doi:10.1016/j.bpsc.2016.03.002

Cited by 17 publications

(11 citation statements)

References 159 publications

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“…There was also a positive association between the cross-disorder PGRS and brain activation during executive functioning in frontal regions, driven by genetic risk for SCZ (Whalley et al 2015 ). Again, this is consistent with previous research implicating altered frontal activation in SCZ during executive function tasks (Costafreda et al 2011 ; Sutcliffe et al 2016 ).…”

Section: Discussionsupporting

confidence: 92%

A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder

Dezhina

Ranlund

Kyriakopoulos

et al. 2018

Brain Imaging and Behavior

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Genetic factors account for up to 80% of the liability for schizophrenia (SCZ) and bipolar disorder (BD). Genome-wide association studies have successfully identified several genes associated with increased risk for both disorders. This has allowed researchers to model the aggregate effect of genes associated with disease status and create a polygenic risk score (PGRS) for each individual. The interest in imaging genetics using PGRS has grown in recent years, with several studies now published. We have conducted a systematic review to examine the effects of PGRS of SCZ, BD and cross psychiatric disorders on brain function and connectivity using fMRI data. Results indicate that the effect of genetic load for SCZ and BD on brain function affects task-related recruitment, with frontal areas having a more prominent role, independent of task. Additionally, the results suggest that the polygenic architecture of psychotic disorders is not regionally confined but impacts on the task-dependent recruitment of multiple brain regions. Future imaging genetics studies with large samples, especially population studies, would be uniquely informative in mapping the spatial distribution of the genetic risk to psychiatric disorders on brain processes during various cognitive tasks and may lead to the discovery of biological pathways that could be crucial in mediating the link between genetic factors and alterations in brain networks.

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Section: Discussionsupporting

confidence: 92%

A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder

Dezhina

Ranlund

Kyriakopoulos

et al. 2018

Brain Imaging and Behavior

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“…There are several important findings that stand out which relate to executive function, memory and the limbic system. For example, THC alters the neural response during working memory performance ( Böcker et al, 2010 ; Bossong, Jager, et al, 2012 ) as seen in schizophrenia ( Sutcliffe et al, 2016 ). Likewise, psychosis is associated with altered threat processing ( Freeman et al, 2013 ) and THC produces complex effects on neural systems underlying fear processing including altered amygdalar response to threat and reduced amygdalo-cortical coupling ( Gorka et al, 2015 ), and THC may be anxiogenic via non-amygdalar pathways.…”

Section: Cannabis and Psychossmentioning

confidence: 99%

The neuropsychopharmacology of cannabis: A review of human imaging studies

Bloomfield

Hindocha

Green

et al. 2019

Pharmacology & Therapeutics

186

103

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The laws governing cannabis are evolving worldwide and associated with changing patterns of use. The main psychoactive drug in cannabis is Δ9-tetrahydrocannabinol (THC), a partial agonist at the endocannabinoid CB1 receptor. Acutely, cannabis and THC produce a range of effects on several neurocognitive and pharmacological systems. These include effects on executive, emotional, reward and memory processing via direct interactions with the endocannabinoid system and indirect effects on the glutamatergic, GABAergic and dopaminergic systems. Cannabidiol, a non-intoxicating cannabinoid found in some forms of cannabis, may offset some of these acute effects. Heavy repeated cannabis use, particularly during adolescence, has been associated with adverse effects on these systems, which increase the risk of mental illnesses including addiction and psychosis. Here, we provide a comprehensive state of the art review on the acute and chronic neuropsychopharmacology of cannabis by synthesizing the available neuroimaging research in humans. We describe the effects of drug exposure during development, implications for understanding psychosis and cannabis use disorder, and methodological considerations. Greater understanding of the precise mechanisms underlying the effects of cannabis may also give rise to new treatment targets.

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“…Atypical antipsychotics show promise for improving cognitive deficits, such as working memory, in those with psychotic disorders, with olanzapine and risperidone being particularly efficacious for cognition (Houthoofd, Morrens, & Sabbe, ; Meltzer & McGurk, ). The cognitive deficits in patients with psychotic disorders are considered to reflect the genetic vulnerability for psychotic disorders (Sutcliffe, Harneit, Tost, & Meyer‐Lindenberg, ).…”

Section: Psychotic Disorders and Working Memorymentioning

confidence: 99%

Effects of working memory training on emotion regulation: Transdiagnostic review

Barkus

2020

PsyCh Journal

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Working memory training is widely used transdiagnostically to improve cognition. However, more recently, studies using working memory training packages have targeted emotion-regulation outcomes to determine whether far transfer effects can be achieved.A narrative review is conducted of studies that have used standardized computerized working memory training packages across healthy volunteers, affect, anxiety, post-traumatic stress disorder (PTSD), and eating disordered populations with emotion-regulation outcomes.Working memory training has been used in children, adolescents, and adults to improve emotion regulation. Many studies have reported gains in mood as well as emotion-regulation strategies following working memory training, regardless of clinical indication and whether near transfer gains were achieved in cognitive domains. Significant emotion-regulation outcomes include: state and trait anxiety, rumination, brooding, positive appraisal, decreasing maladaptive emotion-regulation strategies, and decreasing intrusive thoughts. It is speculated that these far transfer outcomes from working memory training are possible due to the cognitive and neural overlap between cognitive and affective working memory, and emotion regulation. Working memory training could improve cognitive efficiency, which, in turn, increases the availability of cognitive resources during times when emotion regulation is taxed. Future studies need to consider the role of participant expectancy in predicting outcome measure performance, and including subjective and objective outcomes is paramount to study design. Furthermore, sample sizes require additional attention, given that the current review highlights that individual differences in non-clinical and clinical populations influence the outcomes from working memory training. Working memory training offers a possibility for improving emotion regulation transdiagnostically.

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Neuroimaging Intermediate Phenotypes of Executive Control Dysfunction in Schizophrenia

Cited by 17 publications

References 159 publications

A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder

A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder

The neuropsychopharmacology of cannabis: A review of human imaging studies

Effects of working memory training on emotion regulation: Transdiagnostic review

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