1995
DOI: 10.1016/0735-1097(95)00399-1 View full text |Buy / Rent full text
|
|

Abstract: Neurohormonal activation occurs in patients with isolated right ventricular failure and inherently normal left ventricles and appears to be related to the overall severity of cardiopulmonary derangements. The elevation in endothelin levels is consistent with its release in response to pulmonary hypertension.

Help me understand this report

Search citation statements

Order By: Relevance
Select...
2
1
1
9
174
2
5

Year Published

1996
1996
2015
2015

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

9
174
2
5
Order By: Relevance
“…However, all relevant studies are consistent in showing that the ET-1 levels are significantly increased in cases of pulmonary hypertension. The most dramatic increases in circulating ET-1 levels and ET-1 expression, appear to be associated with primary pulmonary hypertension (Stewart et al, 1991;Cacoub et al, 1993;Giaid et al, 1993;Nootens et al, 1995); although ET-1 levels are also significantly increased in pulmonary hypertension secondary to hypoxia (Stewart et al, 1991;Ferri et al, 1995), congenital heart defects (Yoshibayashi et al, 1991;Cacoub et al, 1993;Vincent et al, 1993), valvular heart disease (Stewart et al, 1991;Chang et al, 1993;Yamamoto et al, 1994;Zhu et al, 1994), chronic heart failure (Cody et al, 1992;Kiowski et al, 1995) and the adult respiratory distress syndrome (Langleben et al, 1993). Plasma ET-1 levels can be increased four fold in some of these studies.…”
Section: Resultsmentioning
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 14 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…However, all relevant studies are consistent in showing that the ET-1 levels are significantly increased in cases of pulmonary hypertension. The most dramatic increases in circulating ET-1 levels and ET-1 expression, appear to be associated with primary pulmonary hypertension (Stewart et al, 1991;Cacoub et al, 1993;Giaid et al, 1993;Nootens et al, 1995); although ET-1 levels are also significantly increased in pulmonary hypertension secondary to hypoxia (Stewart et al, 1991;Ferri et al, 1995), congenital heart defects (Yoshibayashi et al, 1991;Cacoub et al, 1993;Vincent et al, 1993), valvular heart disease (Stewart et al, 1991;Chang et al, 1993;Yamamoto et al, 1994;Zhu et al, 1994), chronic heart failure (Cody et al, 1992;Kiowski et al, 1995) and the adult respiratory distress syndrome (Langleben et al, 1993). Plasma ET-1 levels can be increased four fold in some of these studies.…”
Section: Resultsmentioning
“…This retrospective analysis showed NT-proBNP to be an independent predictor of mortality. Plasma ANP is significantly increased in PH of varying aetiologies and, like BNP, correlates with haemodynamic variables [35][36][37][38]. ANP may better reflect short-term haemodynamic changes, owing to different patterns of synthesis, secretion and clearance than BNP [23].…”
Section: Natriuretic Peptidesmentioning
“…In 21 patients with IPAH, elevated ET-1 levels correlated with right atrial pressure and pulmonary artery oxygen saturation [37]. It has been proposed that big ET-1 may be a more reliable indicator of activity of the ET-1 system, owing to a longer half-life and less tissue extraction [47].…”
Section: Natriuretic Peptidesmentioning
“…In PAH 12 as well as in biventricular failure due to HFrEF, 35,36 a biomarker of cardiac adrenergic activation, systemic plasma NE, which mostly originates from cardiac spillover, 37 is directly related to increased mortality. Antiadrenergic therapy in the form of β 1 - Figure 4.…”
Section: Could An Antiadrenergic Treatment Be Effective In Rvf Due Tomentioning
“…[9][10][11] Most importantly, targeting the increased adrenergic activation with β-adrenergic receptor blocking agents has led to the development of arguably the single most effective drug therapy in HFrEF. 11 The pressure-overloaded and ultimately remodeled/failing RV in PAH is also adrenergically activated, 12,13 which raises the issue of whether an antiadrenergic strategy could be effectively employed in this setting. This review will state the case for an antiadrenergic approach to preventing or reversing RV dysfunction in PAH and will provide some thoughts on how such a treatment could be safely and effectively delivered.…”
mentioning