Neurogenic Factors in Contact Dermatitis

Psychological factors associated with hand dermatoses: which subgroup needs additional psychological care?

“…Diagnosis may be made more difficult by reactivity of the skin to contact allergens, which apparently differs at various times. In the 1950s, Guy 6 performed experiments with results that, today, are still very impressive. Allergic reactions to a given material in the same concentration in the same person could vary from 4+ to a negative patch test result and could do so within 3 weeks.…”

A Molecular Explanation of Stress Dermatitis

“…The process may be hastened by release of vasoactive amines and hormones due to psychological reasons, stress, or trauma. As a consequence of the forementioned sequence of events, it is understandable that release of sympathomimetic amines and hormones along with the presence of antigen may perpetu ate or even worsen cell-mediated immunity.Abundant data in literature support the assumption that psychogenic fac tors, anxiety, stress or exhaustion can influence allergic sensitization reactions (Cormia, 1946;Guy, 1952; Polak and Bielicky, 1953\Poldk, 1955, \951\Mier-zecki et al, 1959,Storck, 1960, Brown and Young, 1959, 1965\Shanon, 1970. Mettrop and Visser (1969) found in guinea pigs that the probability of skin reactions of delayed-type hypersensitivity to DNCB in a subthreshold concentra tion was significantly greater in the once-stressed group compared to the control group.…”

Exteroceptive Stimulation as a Contingent Factor in the Induction and Elicitation of Delayed Type Hypersensitivity Reactions to 1 Chloro‐, 2‐4, Dinitrobenzene in Guinea Pigs

“…It should be pointed out that De Week and Erey (1966), in discussing tolerance for allergens of simple chemical structure, deny the direct infiuence of the nervous system on induction and elicitation of delayed-type hypersensitivity skin-reactions. Nevertheless the authors refer to an earlier publication (Guy, 1952), which reports that interference with the sleep cycle of animal subjects changed the overt behavior and increased the response of their skin to repeated contacts with sensitizing agents. The outcome of recent research leads to the conclusion that 386 METTROP AND VISSER Vol.…”