Neurofibrillary Tangles, Amyloid, and Memory in Aging and Mild Cognitive Impairment

Abstract

Neurofibrillary tangles are more numerous in medial temporal lobe regions associated with memory function and show a relationship to performance on memory tests in nondemented individuals. These results suggest that NFTs may constitute a pathological substrate for memory loss not only in AD but also in normal aging and MCI.

Memory performance is related to amyloid and tau pathology in the hippocampus

“…In contrast with previous studies,28 32 we have shown that amyloid plaques in either region of the hippocampal formation, particularly in the entorhinal cortex, were associated with memory function in cross sectional and longitudinal analyses. This is consistent with the viewpoint that both early and late memory loss in AD is related to Aβ neurotoxicity.…”

Memory performance is related to amyloid and tau pathology in the hippocampus

“…In contrast with previous studies,28 32 we have shown that amyloid plaques in either region of the hippocampal formation, particularly in the entorhinal cortex, were associated with memory function in cross sectional and longitudinal analyses. This is consistent with the viewpoint that both early and late memory loss in AD is related to Aβ neurotoxicity.…”

Imaging myelin degradation in ex vivo prefrontal cortex tissue blocks in Alzheimer's disease and chronic traumatic encephalopathy

“…As expected, the value of close to 0% for AT8 staining in NC is consistent with other studies that confirm that less p‐tau deposition is correlated with healthy subjects 48 . NC images presented little or no staining with Ab4G8, and the clear separation of the GM and WM layers was observed.…”

Differential FDDNP PET Patterns in Nondemented Middle-Aged and Older Adults

“…The HF/PA cluster was the most diagnostically diverse, with 71% MCI and 29% cognitively normal subjects. Neuropathological studies indicate a greater degree of amyloid and tau pathology in MCI compared to cognitively normal older persons6,7, 26, which is consistent with the current findings of more MCI patients in the two clusters with relatively higher FDDNP signal. Others have found variable binding patterns in MCI and healthy controls using Pittsburg Compound B ([11C]PIB) 27, which has been reported to have in vivo specificity for A-beta plaques, but is not known to label neurofibrillary tangle pathology.…”

Memory performance is related to amyloid and tau pathology in the hippocampus

“…In contrast with previous studies,28 32 we have shown that amyloid plaques in either region of the hippocampal formation, particularly in the entorhinal cortex, were associated with memory function in cross sectional and longitudinal analyses. This is consistent with the viewpoint that both early and late memory loss in AD is related to Aβ neurotoxicity.…”

Imaging myelin degradation in ex vivo prefrontal cortex tissue blocks in Alzheimer's disease and chronic traumatic encephalopathy

“…As expected, the value of close to 0% for AT8 staining in NC is consistent with other studies that confirm that less p‐tau deposition is correlated with healthy subjects 48 . NC images presented little or no staining with Ab4G8, and the clear separation of the GM and WM layers was observed.…”

Differential FDDNP PET Patterns in Nondemented Middle-Aged and Older Adults

“…The HF/PA cluster was the most diagnostically diverse, with 71% MCI and 29% cognitively normal subjects. Neuropathological studies indicate a greater degree of amyloid and tau pathology in MCI compared to cognitively normal older persons6,7, 26, which is consistent with the current findings of more MCI patients in the two clusters with relatively higher FDDNP signal. Others have found variable binding patterns in MCI and healthy controls using Pittsburg Compound B ([11C]PIB) 27, which has been reported to have in vivo specificity for A-beta plaques, but is not known to label neurofibrillary tangle pathology.…”

Memory performance is related to amyloid and tau pathology in the hippocampus

“…In contrast with previous studies,28 32 we have shown that amyloid plaques in either region of the hippocampal formation, particularly in the entorhinal cortex, were associated with memory function in cross sectional and longitudinal analyses. This is consistent with the viewpoint that both early and late memory loss in AD is related to Aβ neurotoxicity.…”

Imaging myelin degradation in ex vivo prefrontal cortex tissue blocks in Alzheimer's disease and chronic traumatic encephalopathy

“…As expected, the value of close to 0% for AT8 staining in NC is consistent with other studies that confirm that less p‐tau deposition is correlated with healthy subjects 48 . NC images presented little or no staining with Ab4G8, and the clear separation of the GM and WM layers was observed.…”

Differential FDDNP PET Patterns in Nondemented Middle-Aged and Older Adults

“…The HF/PA cluster was the most diagnostically diverse, with 71% MCI and 29% cognitively normal subjects. Neuropathological studies indicate a greater degree of amyloid and tau pathology in MCI compared to cognitively normal older persons6,7, 26, which is consistent with the current findings of more MCI patients in the two clusters with relatively higher FDDNP signal. Others have found variable binding patterns in MCI and healthy controls using Pittsburg Compound B ([11C]PIB) 27, which has been reported to have in vivo specificity for A-beta plaques, but is not known to label neurofibrillary tangle pathology.…”