Neuroendocrine dysfunction in patients recovering from subarachnoid hemorrhage

Jovanović, Vladimir; Pekić, Sandra; Stojanović, Marko; Tasić, Goran; Djurovic, B.M.; Soldatović, Ivan; Doknic, Mirjana; Miljić, Dragana; Djurović, Marina; Medić-Stojanoska, Milica; Popović, Vera

doi:10.14310/horm.2002.1273

Cited by 34 publications

(39 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Both treatment groups exhibited cognitive impairments in memory, attention and speed of information processing (4). Previous clinical studies have indicated that long-term survivors of aSAH frequently exhibit hypothyroidism (5,6). Furthermore, cognitive dysfunctions in these patients resemble the disruptions observed in patients with hypothyroidism.…”

Section: Introductionmentioning

confidence: 89%

Effect of thyroid hormone replacement therapy on cognition in long-term survivors of aneurysmal subarachnoid hemorrhage

Yang

Yin

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Aneurysmal subarachnoid hemorrhage (aSAH) is a recently identified risk factor for chronic hypothyroidism. Patients with hypothyroidism often exhibit cognitive dysfunction. The aim of the present study was to determine the effects of thyroid hormone replacement therapy on cognition in aSAH survivors with hypothyroidism. A study population of 135 patients was recruited and subjected to the Montreal Cognitive Assessment (MoCA) and Beck Depression Inventory. Among the study population, 52 patients exhibited cognitive dysfunction. Thyroid hormone levels were measured in these patients using an electrochemiluminescence immunoassay in order to elucidate possible deficits in the thyrotrophic hormonal axes, and hypothyroidism was confirmed in 31 patients. Among these 31 patients, 22 patients consented to be randomized into groups and were administered levothyroxine replacement or a placebo treatment for 3 months. The MoCA and Wechsler Adult Intelligence Scale-Chinese version (WAIS-RC) testing were performed prior to and following the replacement therapy or placebo treatments. All subjects completed the study with no negative side effects. After 8-12 weeks of oral levothyroxine administration, it was observed that the serum concentration of thyroid-stimulating hormone was restored to normal levels. Furthermore, neuropsychological test results improved following the replacement therapy. A significant improvement was observed in the MoCA scores of the replacement group following therapy, with the exception of the score for abstraction. Additionally, significant improvements in the WAIS-RC were observed in the replacement group, with the exceptions of the information comprehension and letter-number sequencing scores. Thus, the present study has demonstrated the partial normalization of cognitive impairments in patients with hypothyroidism following aSAH as a result of appropriate levothyroxine replacement therapy.

show abstract

Section: Introductionmentioning

confidence: 89%

Effect of thyroid hormone replacement therapy on cognition in long-term survivors of aneurysmal subarachnoid hemorrhage

Yang

Yin

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…We also separately noted the percentage of endocrine abnormalities detected during the acute and chronic phase after SAH. The ''acute phase'' was defined as the occurrence of pituitary dysfunction within the first 6 months after aSAH, and the ''chronic phase'' included endocrine dysfunction occurring after 6 months from aSAH, as suggested by the authors [10][11][12][13][14][15][16][17][18].…”

Section: Endocrine Dysfunctionmentioning

confidence: 99%

“…Kreitschmann-Andermahr et al [45] found a significant association between female sex and the prevalence of corticotrophin deficiency. Jovanovic et al [14] identified cerebral vasospasm and hydrocephalus as risk factors for pituitary dysfunction in a series of 93 patients with SAH; however, no data regarding the treatment modality of the aneurysm are available. Outcome of the patient Table 5 describes the association between different variables and risk factors (including the prevalence of pituitary dysfunction) on the functional outcome of the patient (described as median GOS).…”

Section: Factors Influencing the Prevalence Of Pituitary Disordersmentioning

confidence: 99%

“…Some are focused on the acute phase of aSAH [13,15], others on the chronic phase of aSAH [16,17], while some adress both [10,18]. There is substantial heterogeniety in the conclusions of these studies: although some suggest that hypopituitarism after aSAH affects only exceptional cases [19,20], others describe a high incidence reaching up to 50 % of cases [9,11,14]. Further, the clinical impact of any endocrine abnormalities that are present after aSAH remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical prevalence and outcome impact of pituitary dysfunction after aneurysmal subarachnoid hemorrhage: a systematic review with meta-analysis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The substantial production of endothelin and vascular vasopressin could further aggravate cerebral ischemia. Previous studies reported that the mild hypothermia could reduce the level of endothelin and vascular vasopressin 40,48…”

Section: Discussionmentioning

confidence: 97%

Local mild hypothermia therapy as an augmentation strategy for minimally invasive surgery of hypertensive intracerebral hemorrhage: a meta-analysis of randomized clinical trials

Han¹,

Sheng²,

Su³

et al. 2016

NDT

View full text Add to dashboard Cite

BackgroundPrevious studies reported that the mild hypothermia therapy (MHT) could significantly improve the clinical outcomes for patients with hypertensive intracerebral hemorrhage (HICH). Therefore, this meta-analysis was conducted to systematically assess whether the addition of local MHT (LMHT) could significantly improve the efficacy of minimally invasive surgery (MIS) in treating HICH.MethodsRandomized clinical trials on the combined application of MIS and LMHT (MIS+LMHT) vs MIS alone for treating HICH were searched up to September 2016 in databases. Response rate and mortality rate were the primary outcomes, and the neurologic function and Barthel index were the secondary outcomes. Side effects were also analyzed.ResultsTotally, 28 studies composed of 2,325 patients were included to compare the efficacy of MIS+LMHT to MIS alone. The therapeutic effects of MIS+LMHT were significantly better than MIS alone. The pooled odds ratio of response rate and mortality rate was 2.68 (95% confidence interval [CI]=2.22–3.24) and 0.43 (95% CI=0.32–0.57), respectively. In addition, the MIS+LMHT led to a significantly better improvement in the neurologic function and activities of daily living. The incidence of pneumonia was similar between the two treatment methods.ConclusionThese results indicated that compared to MIS alone, the MIS+LMHT could be more effective for the acute treatment of patients with HICH. This treatment modality should be further explored and optimized.

show abstract

Neuroendocrine dysfunction in patients recovering from subarachnoid hemorrhage

Cited by 34 publications

References 28 publications

Effect of thyroid hormone replacement therapy on cognition in long-term survivors of aneurysmal subarachnoid hemorrhage

Effect of thyroid hormone replacement therapy on cognition in long-term survivors of aneurysmal subarachnoid hemorrhage

Clinical prevalence and outcome impact of pituitary dysfunction after aneurysmal subarachnoid hemorrhage: a systematic review with meta-analysis

Local mild hypothermia therapy as an augmentation strategy for minimally invasive surgery of hypertensive intracerebral hemorrhage: a meta-analysis of randomized clinical trials

Contact Info

Product

Resources

About