Neurocysticercosis Among Patients With Cerebral Gliomas

Brutto, Oscar H. Del; Castillo, Pablo R.; Mena, Iván X.; Freire, Amado X.

doi:10.1001/archneur.1997.00550210057013

Cited by 55 publications

(43 citation statements)

References 23 publications

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“…The lesions in the growth and cellular diferentiation were identified in the host-parasite interface in one NCC case and is in accordance to the literature 32 which indicates a significant association between NCC and gliomas.…”

Section: Fig 3 Host-parasite Interface Nearby a Cysticercus In Destrsupporting

confidence: 90%

Anatomopathological aspects of neurocysticercosis in autopsied patients

Lino-Júnior

Faleiros²,

Vinaud

et al. 2007

Arq. Neuro-Psiquiatr.

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-The aim of this paper was to describe the occurrence and morphology of neurocysticercosis (NCC) in autopsies. We revised 2218 autopsies performed at the School Hospital from Federal Unversity of Triangulo Mineiro, 1970Mineiro, -2003. Data referring to age, gender and color of patients were reported and NCC was microscopically and macroscopically analyzed. We found 53 (2.4%) NCC cases. The mean age was 50 years old, 34 (64.1%) individuals were male and 36 (67.9%) white. Macroscopically, 17 cysticerci were analyzed. The most frequent location was meningocortical in 12 (70.6%) cases. Microscopically, the cysticerci presented an ovoid shape, containing the larvae preserved in 4 (23.5%) cases or in destruction degrees in 13 (76.5%) cases. Therefore, in NCC was found several general pathologic processes (necrosis, interstitial deposits, fibrosis, gliosis, inflammation) amongst which are highlighted beta-fibrillose in 13 (76.5%) cases associated to inflammatory process in 16 (94.1%) cases caused by the parasite, not yet related to NCC, and calcification present in viable and destruction parasites.KEY WORDS: autopsy neurocysticercosis, general pathologic processes, cysticercosis, central nervous system. Aspectos anatomopatológicos da neurocisticercose em pacientes autopsiadosRESUMO -O objetivo desse trabalho foi descrever ocorrência e morfologia da neurocisticercose (NCC) autópsias. Revisou-se 2218 autópsias realizadas no Hospital Escola da Universidade Federal do Triângulo Mineiro (UFTM), 1970-2003. Registrou-se idade, gênero e cor dos pacientes, analisou-se macroscopia e microscopia da NCC. Encontrou-se 53 (2,4%) casos de NCC. A média das idades foi 50 anos, sendo 34 (64,1%) do sexo masculino e 36 (67,9%) brancos, não havendo diferença significante na comparação da idade, gênero e cor dos pacientes. Analisou-se macroscopicamente 17 cisticercos. A localização mais comum foi a meningocortical em 12 (70,6%) casos. Microscopicamente, os cisticercos apresentaram forma oval contendo a larva íntegra em 4 (23,5%) casos ou em grau de destruição em 13 (76,5%) casos. Portanto, na NCC foram verificados vários processos patológicos gerais (necrose, depósitos intersticiais, fibrose, gliose, inflamação) destacando-se: beta-fibrilose em 13 (76,5%) casos associada ao processo inflamatório em 16(94,1%) casos causado pelo parasito, ainda não relatada na NCC, e calcificação presente no parasito viável e em destruição. PALAVRAS-CHAVE: autópsia, neurocisticercose, processos patológicos gerais, cisticercose, sistema nervoso central.Human cysticercosis occurs due to ingestion, with contaminated food, of eggs containing oncospheres. In the intestinal portion the oncospheres hatch, penetrate in the intestinal wall and disseminate through blood and lymph vessels until it gets to several tissues, however with great tropism to the central nervous system (CNS) 1,2 . Neurocysticercosis (NCC) is characterized by presenting several clinic manifestations 3 . The polymorphism of its clinic manifestations depends not only on its localization ...

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Section: Fig 3 Host-parasite Interface Nearby a Cysticercus In Destrsupporting

confidence: 90%

Anatomopathological aspects of neurocysticercosis in autopsied patients

Lino-Júnior

Faleiros²,

Vinaud

et al. 2007

Arq. Neuro-Psiquiatr.

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“…solium neurocysticercosis is also associated with malignant diseases in humans. Del Brutto et al [1997] and Herrera et al [1999; found a higher than expected frequency of glioma and hematological malignancy among patients with neurocysticercosis. There also have been isolated cases of patients with cysticercosis who have developed multiple myeloma [Duren et al, 1956], astrocytomas [Hautecoeur et al, 1987], leukemia [Ridaura-Sánz, 1987], and oligodendrogliomas [Agapejev et al, 1992].…”

Section: Introductionmentioning

confidence: 70%

Genotoxicity of vesicular fluid and saline extract of Taenia solium metacestodes in somatic cells of Drosophila melanogaster

Silva

Costa-Cruz

Spanó

et al. 2006

Environ and Mol Mutagen

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Neurocysticercosis, the most common parasitic disease of the central nervous system, is caused by cysticerci of the helminth Taenia solium, which is prevalent in developing countries and is reemerging in affluent societies. This helminth is associated with brain tumors and hematological malignancies in humans. In the present study, we analyzed the genotoxicity of vesicular fluid (VF) and a saline extract (SE) of T. solium metacestodes in the Drosophila melanogaster wing somatic mutation and recombination test (SMART). Third-instar larvae derived from standard and high bioactivation crosses were treated for approximately 48 hr with 12.5, 25.0, and 50.0 microg/ml of VF and SE of T. solium metacestodes. Negative (phosphate buffered saline) and positive (10 mM urethane) controls were also included. The results showed that the two test compounds were genotoxic in both crosses of Drosophila. Nevertheless, further research is needed to determine the genotoxic potential of specific compounds present in VF and SE and their role in the development of cancer.

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“…This depressed immunity may be responsible for the reported association of this parasitic disease with conditions resulting from immunological disturbances such as hematological malignancies and conditions leading to the development of cerebral tumors. 18,19,38 CLINICAL MANIFESTATIONS Neurocysticercosis may affect males and females from birth through advanced age; however, the peak age of its incidence is in middle-aged adults. The disease may present with a variety of clinical manifestations, a pleomorphic quality that is related to individual differences in the number and location of the lesions within the CNS.…”

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confidence: 99%

Review of neurocysticercosis

Sotelo¹,

Brutto²

2002

FOC

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In the neurosurgical services in many developing countries, treatment of neurocysticercosis (NCC) accounts for greater than 10% of brain surgical procedures and approximately 15% of neurological consultations. In these areas brain cysticercosis is the leading cause of hydrocephalus in adults and the first cause of late-onset epilepsy. During the last two decades, successful medical treatment has been established. Additionally, neuroimaging and immunological studies have clearly defined the topography, pathophysiological mechanisms, and biological status of these lesions. Thus, selection of cases for medical or surgical treatment has improved; in a significant number of cases, both interventions are required. New therapies with either albendazole or praziquantel have respectively reduced to 8 days and to 1 day the course of anticysticidal therapy, which now is fast, effective, inexpensive, atoxic, and convenient, particularly in endemic areas where most patients belong to the lower socioeconomic groups. Additionally, the rational use of steroid agents facilitates the treatment of inflammation, a conspicuous accompaniment in cases of NCC. A major effort, however, is still required to eradicate this disease.

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Neurocysticercosis Among Patients With Cerebral Gliomas

Cited by 55 publications

References 23 publications

Anatomopathological aspects of neurocysticercosis in autopsied patients

Anatomopathological aspects of neurocysticercosis in autopsied patients

Genotoxicity of vesicular fluid and saline extract of Taenia solium metacestodes in somatic cells of Drosophila melanogaster

Review of neurocysticercosis

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