Neurochemical Effects of Vitamins C, E and DMSO Combinations on Oxidative Stress Biomarkers and Severity of Ischemic Stroke in Wistar Rats

Abstract

Stroke is a growing disease and is the third commonest cause of death in the world after coronary heart disease and cancer, especially in the elderly [1]. In Nigeria, Stroke constitutes about 2.4% of all emergency admissions with cerebral infarction making up to 49% of all cases [2]. The burden of Stroke in Nigeria is such that it is responsible for 1.8% of all deaths in the emergency unit with case fatality rates that increase from 9% to 46%, depending on the duration of the event [2].Stroke treatment is dependent on whether it is ischaemic or haemorrhagic, and therefore diagnosis within the first six hours after onset of symptoms is essential if patients with ischaemic stroke are to benefit from t-PA therapy since it is the only FDA