Neurochemical Changes in White Matter

Yet more evidence that myelin protons can be directly imaged with UTE sequences on a clinical 3T scanner: Bicomponent analysis of native and deuterated ovine brain specimens

“…Fitting the signal in complex images would provide more accurate estimation of f S . Besides, more advanced inversion recovery UTE sequences are currently under investigation by our team (39) and another group (40) to simultaneously suppress long T 2 water signals with a broad range of T 1 s. Second, our f S values were relatively small compared with the known myelin tissue concentration in the wet mass of WM (41,42). This might be due to insufficient nulling of LTCs.…”

Yet more evidence that myelin protons can be directly imaged with UTE sequences on a clinical 3T scanner: Bicomponent analysis of native and deuterated ovine brain specimens

“…Fitting the signal in complex images would provide more accurate estimation of f S . Besides, more advanced inversion recovery UTE sequences are currently under investigation by our team (39) and another group (40) to simultaneously suppress long T 2 water signals with a broad range of T 1 s. Second, our f S values were relatively small compared with the known myelin tissue concentration in the wet mass of WM (41,42). This might be due to insufficient nulling of LTCs.…”

Neurodegeneration and Neuro-Regeneration—Alzheimer’s Disease and Stem Cell Therapy

“…Oligodendrocytes exhibit specific morphological changes during AD progression. Deterioration in myelin integrity and axonal destruction have been observed [64,65,66,67,68,69]. However, studies on mouse models and hAD samples have shown that there is no reduction of the overall amount of myelin [70,71,72].…”

The Biology of Glial Cells and Their Complex Roles in Alzheimer’s Disease: New Opportunities in Therapy

“…These cells are responsible for providing insulation and support to the neuronal axons in the CNS required for the fast action potential propagation. Evidence suggests that structural and spatial organization of myelin lipid bilayers have a strong connection with the pathogenesis of AD [ 91 , 92 ]. As with microglia and astrocytes, oligodendrocytes have also been shown to exhibit specific morphological changes during AD progression.…”

“…As with microglia and astrocytes, oligodendrocytes have also been shown to exhibit specific morphological changes during AD progression. In 15-month-old PDAPP mice as well as hAD samples, researchers have used imaging studies and X-ray diffraction to show that near the Aβ plaques, there is noticeable deterioration in myelin integrity and axonal destruction [ 91 , 93 , 94 , 95 , 96 ]. Electron microscopy and myelin staining revealed that 2–6 month-old 3xTg-AD mice compared to control groups exhibit myelin sheath alterations and impairment of axonal morphology possibly due to a loss of oligodendrocytes [ 97 , 98 ].…”

Yet more evidence that myelin protons can be directly imaged with UTE sequences on a clinical 3T scanner: Bicomponent analysis of native and deuterated ovine brain specimens

“…Fitting the signal in complex images would provide more accurate estimation of f S . Besides, more advanced inversion recovery UTE sequences are currently under investigation by our team (39) and another group (40) to simultaneously suppress long T 2 water signals with a broad range of T 1 s. Second, our f S values were relatively small compared with the known myelin tissue concentration in the wet mass of WM (41,42). This might be due to insufficient nulling of LTCs.…”

Neurodegeneration and Neuro-Regeneration—Alzheimer’s Disease and Stem Cell Therapy

“…Oligodendrocytes exhibit specific morphological changes during AD progression. Deterioration in myelin integrity and axonal destruction have been observed [64,65,66,67,68,69]. However, studies on mouse models and hAD samples have shown that there is no reduction of the overall amount of myelin [70,71,72].…”

The Biology of Glial Cells and Their Complex Roles in Alzheimer’s Disease: New Opportunities in Therapy

“…These cells are responsible for providing insulation and support to the neuronal axons in the CNS required for the fast action potential propagation. Evidence suggests that structural and spatial organization of myelin lipid bilayers have a strong connection with the pathogenesis of AD [ 91 , 92 ]. As with microglia and astrocytes, oligodendrocytes have also been shown to exhibit specific morphological changes during AD progression.…”

“…As with microglia and astrocytes, oligodendrocytes have also been shown to exhibit specific morphological changes during AD progression. In 15-month-old PDAPP mice as well as hAD samples, researchers have used imaging studies and X-ray diffraction to show that near the Aβ plaques, there is noticeable deterioration in myelin integrity and axonal destruction [ 91 , 93 , 94 , 95 , 96 ]. Electron microscopy and myelin staining revealed that 2–6 month-old 3xTg-AD mice compared to control groups exhibit myelin sheath alterations and impairment of axonal morphology possibly due to a loss of oligodendrocytes [ 97 , 98 ].…”

Yet more evidence that myelin protons can be directly imaged with UTE sequences on a clinical 3T scanner: Bicomponent analysis of native and deuterated ovine brain specimens

“…Fitting the signal in complex images would provide more accurate estimation of f S . Besides, more advanced inversion recovery UTE sequences are currently under investigation by our team (39) and another group (40) to simultaneously suppress long T 2 water signals with a broad range of T 1 s. Second, our f S values were relatively small compared with the known myelin tissue concentration in the wet mass of WM (41,42). This might be due to insufficient nulling of LTCs.…”

Neurodegeneration and Neuro-Regeneration—Alzheimer’s Disease and Stem Cell Therapy

“…Oligodendrocytes exhibit specific morphological changes during AD progression. Deterioration in myelin integrity and axonal destruction have been observed [64,65,66,67,68,69]. However, studies on mouse models and hAD samples have shown that there is no reduction of the overall amount of myelin [70,71,72].…”

The Biology of Glial Cells and Their Complex Roles in Alzheimer’s Disease: New Opportunities in Therapy

“…These cells are responsible for providing insulation and support to the neuronal axons in the CNS required for the fast action potential propagation. Evidence suggests that structural and spatial organization of myelin lipid bilayers have a strong connection with the pathogenesis of AD [ 91 , 92 ]. As with microglia and astrocytes, oligodendrocytes have also been shown to exhibit specific morphological changes during AD progression.…”

“…As with microglia and astrocytes, oligodendrocytes have also been shown to exhibit specific morphological changes during AD progression. In 15-month-old PDAPP mice as well as hAD samples, researchers have used imaging studies and X-ray diffraction to show that near the Aβ plaques, there is noticeable deterioration in myelin integrity and axonal destruction [ 91 , 93 , 94 , 95 , 96 ]. Electron microscopy and myelin staining revealed that 2–6 month-old 3xTg-AD mice compared to control groups exhibit myelin sheath alterations and impairment of axonal morphology possibly due to a loss of oligodendrocytes [ 97 , 98 ].…”