Neurobehavioural and Electrophysiological Effects of Lead in Rats and Monkeys

Lilienthal, Hellmuth; Muñoz, Carmen; Winneke, Gerhard; Lenaerts, C.; Hennekes, R

doi:10.1007/978-94-009-0847-5_27

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…In some studies, lead is most closely Volume 104, Number 10, October 1996 * Environmental Health Perspectives related to loss in verbal skills; in others, it is nonverbal skills. However, Lilienthal et al (53) found that the behavioral profile in rats with chemically induced lesions of the hippocampus differed from patterns obtained in rats with prenatal exposure to lead and that chemical lesions of the amygdala show a greater similarity with leadinduced effects, suggesting that the hippocampus is not the sole target for lead toxicity. Lead related losses in visual motor integration, poorer performance on tasks of serial learning, and increased errors in tasks requiring perseverance in experimatal animal models are generally consistent with clinical findings and are thought to pinpoint the hippocampus as the primary target for neurobehavioral effects (47-50).…”

Section: Mechanisms For Neurological Effects Of Leadmentioning

confidence: 97%

Results of Lead Research: Prenatal Exposure and Neurological Consequences

Goyer¹

1996

Environmental Health Perspectives

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. The National Institute of Environmental Health Sciences (NIEHS) and Brogan & Partners are collaborating with JSTOR to digitize, preserve and extend access to Environmental Health Perspectives.The history of advances in the understanding of the toxic effects of lead over the past 20 years is an outstanding example of how knowledge learned from research can impact public health. Measures that have had the greatest impact on reducing exposure to lead are reduction of lead from gasoline, elimination of lead solder from canned food, removal of lead from paint, and abatement of housing containing lead-based paint. Nevertheless, continuing factors that enhance risk to lead exposure, particularly during fetal life, are low socioeconomic status, old housing with lead-containing paint, and less than ideal nutrition, particularly low dietary intake of calcium, iron, and zinc. Prenatal exposure may result from endogenous sources such as lead in the maternal skeletal system or maternal exposures from diet and the environment. Experimental studies have shown that the developing nervous system is particularly sensitive to the toxic effects of lead and that a large number of the effects in the nervous system are due to interference of lead with biochemical functions dependent on calcium ions and impairment of neuronal connections dependent on dendritic pruning. There is need for more study to determine whether these effects are a continuum of prenatal lead exposure or whether prenatal exposure to lead produces unique effects. Key words: blood lead levels, fetal brain, fetal susceptibility, lead, mechanisms of central nervous system effects, neurological effects, pregnancy, prenatal exposure, risk factors. Environ Health Perspect

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Section: Mechanisms For Neurological Effects Of Leadmentioning

confidence: 97%

Results of Lead Research: Prenatal Exposure and Neurological Consequences

Goyer¹

1996

Environmental Health Perspectives

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“…Also, the hippocampus is known to accumulate lead in humans (51) and rat pups exposed to lead (52). However, Lilienthal et al (53) found that the behavioral profile in rats with chemically induced lesions of the hippocampus differed from patterns obtained in rats with prenatal exposure to lead and that chemical lesions of the amygdala show a greater similarity with leadinduced effects, suggesting that the hippocampus is not the sole target for lead toxicity.…”

Section: Mechanisms For Neurological Effects Of Leadmentioning

confidence: 99%

Results of lead research: prenatal exposure and neurological consequences.

Goyer

1996

Environ Health Perspect

187

View full text Add to dashboard Cite

The history of advances in the understanding of the toxic effects of lead over the past 20 years is an outstanding example of how knowledge learned from research can impact public health. Measures that have had the greatest impact on reducing exposure to lead are reduction of lead from gasoline, elimination of lead solder from canned food, removal of lead from paint, and abatement of housing containing lead-based paint. Nevertheless, continuing factors that enhance risk to lead exposure, particularly during fetal life, are low socioeconomic status, old housing with lead-containing paint, and less than ideal nutrition, particularly low dietary intake of calcium, iron, and zinc. Prenatal exposure may result from endogenous sources such as lead in the maternal skeletal system or maternal exposures from diet and the environment. Experimental studies have shown that the developing nervous system is particularly sensitive to the toxic effects of lead and that a large number of the effects in the nervous system are due to interference of lead with biochemical functions dependent on calcium ions and impairment of neuronal connections dependent on dendritic pruning. There is need for more study to determine whether these effects are a continuum of prenatal lead exposure or whether prenatal exposure to lead produces unique effects.Imagesp1050-aFigure 1. AFigure 1. BFigure 2.Figure 3.

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Neurobehavioural and Electrophysiological Effects of Lead in Rats and Monkeys

Cited by 2 publications

References 22 publications

Results of Lead Research: Prenatal Exposure and Neurological Consequences

Results of Lead Research: Prenatal Exposure and Neurological Consequences

Results of lead research: prenatal exposure and neurological consequences.

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