Neurobehavioral protection by single dose l-deprenyl against MPTP-induced parkinsonism in common marmosets

Ando, Kiyoshi; Maeda, Jun; Inaji, Motoki; Okauchi, Takashi; Obayashi, Shigeru; Higuchi, Makoto; Suhara, Tetsuya; Tanioka, Yoshikuni

doi:10.1007/s00213-007-0929-2

Cited by 37 publications

(28 citation statements)

References 22 publications

(30 reference statements)

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“…The common marmoset ( Callithrix jacchus ) is an increasingly popular NHP species for developing models of neurological disorders (‘t Hart et al, 2000; Okano, Hikishima, Iriki, & Sasaki, 2012; Tardif, Abee, & Mansfield, 2011). Conditions such as Parkinson’s disease (Ando et al, 2008; Ando et al, 2012; Gnanalingham, Smith, Hunter, Jenner, & Marsden, 1993; Huot et al, 2012), Huntington’s disease (Kendall et al, 1998; Maclean, Baker, Ridley, & Mori, 2000), Alzheimer’s disease (Baker, Ridley, Duchen, Crow, & Bruton, 1993) and multiple sclerosis (‘t Hart et al, 2000; Genain & Hauser, 1997) have been modeled in marmosets mainly by neurotoxin administration. Advances in the role of genetics in these disorders, as well as in the tools to generate transgenic and genomic edited models, are moving the field towards a new generation of disease models.…”

Section: Introductionmentioning

confidence: 99%

Cross‐species comparison of behavioral neurodevelopmental milestones in the common marmoset monkey and human child

Ausderau

Dammann

McManus

et al. 2017

Developmental Psychobiology

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The common marmoset (Callithrix jacchus) is an increasingly popular non-human primate species for developing transgenic and genomic edited models of neurological disorders. These models present an opportunity to assess from birth the impact of genetic mutations and to identify candidate predictive biomarkers of early disease onset. In order to apply findings from marmosets to humans, a cross-species comparison of typical development is essential. Aiming to identify similarities, differences, and gaps in knowledge of neurodevelopment we evaluated peer-reviewed literature focused on the first six months of life of marmosets and compared to humans. Five major developmental constructs, including reflexes and reactions, motor, feeding, self-help, and social, were compared. Numerous similarities were identified in the developmental sequences with differences often influenced by the purpose of the behavior, specifically for marmoset survival. The lack of detailed knowledge of marmoset development was exposed as related to the vast resources for humans.

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Section: Introductionmentioning

confidence: 99%

Cross‐species comparison of behavioral neurodevelopmental milestones in the common marmoset monkey and human child

Ausderau

Dammann

McManus

et al. 2017

Developmental Psychobiology

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“…Our success with deriving transgenic Callithrix embryonic stem cell clones allows the use of these reporter cell lines to follow and track transplanted cells in preclinical studies. Furthermore, targeted gene knockdown could be developed using overexpression or short hairpin RNA interference (shRNAi) vectors [20] to study human diseases involving the loss of function of specific genes in nonhuman primates, including Huntington's disease [21], spinal cord injury [22], and Parkinson's disease [23]. …”

Section: Discussionmentioning

confidence: 99%

Derivation of Neural Progenitors and Retinal Pigment Epithelium from Common Marmoset and Human Pluripotent Stem Cells

Torrez

Perez

Yang

et al. 2012

Stem Cells International

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Embryonic and induced pluripotent stem cells (IPSCs) derived from mammalian species are valuable tools for modeling human disease, including retinal degenerative eye diseases that result in visual loss. Restoration of vision has focused on transplantation of neural progenitor cells (NPCs) and retinal pigmented epithelium (RPE) to the retina. Here we used transgenic common marmoset (Callithrix jacchus) and human pluripotent stem cells carrying the enhanced green fluorescent protein (eGFP) reporter as a model system for retinal differentiation. Using suspension and subsequent adherent differentiation cultures, we observed spontaneous in vitro differentiation that included NPCs and cells with pigment granules characteristic of differentiated RPE. Retinal cells derived from human and common marmoset pluripotent stem cells provide potentially unlimited cell sources for testing safety and immune compatibility following autologous or allogeneic transplantation using nonhuman primates in early translational applications.

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“…The behavioral characteristics of marmosets in the framework of preclinical PD studies have been described in previous studies [19]. In more detail, normal marmosets in individual living cages move freely, leap between mesh cage walls, and cling to the walls in the daytime, and are sedentary at night.…”

Section: Introductionmentioning

confidence: 97%

“…Thus, MPTP is often used to establish PD model in various primate species, including baboons [12], macaques [6], [13], velvet monkeys [14], squirrel monkeys [7], [15] and common marmosets [16], [17], [18], for studying the pathophysiology, etiology, pathogenesis, and possible treatment options for PD. Preclinical (non-clinical) studies have shown that the common marmoset is a suitable model for not only the identification of effective pharmacological treatments but also the evaluation of neuroprotective therapies [19], [20], [21], [22], [23].…”

Section: Introductionmentioning

confidence: 99%

PET Analysis of Dopaminergic Neurodegeneration in Relation to Immobility in the MPTP-Treated Common Marmoset, a Model for Parkinson’s Disease

Ando

Obayashi

Nagai³

et al. 2012

PLoS ONE

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BackgroundPositron Emission Tomography (PET) measurement was applied to the brain of the common marmoset, a small primate species, treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The marmoset shows prominent Parkinson’s disease (PD) signs due to dopaminergic neural degeneration. Recently, the transgenic marmoset (TG) carrying human PD genes is developing. For phenotypic evaluations of TG, non-invasive PET measurement is considered to be substantially significant. As a reference control for TG, the brain of the MPTP-marmoset as an established and valid model was scanned by PET. Behavioral analysis was also performed by recording locomotion of the MPTP-marmoset, as an objective measure of PD signs.Methodology/Principal FindingsMarmosets received several MPTP regimens (single MPTP regimen: 2 mg/kg, s.c., per day for 3 consecutive days) were used for PET measurement and behavioral observation. To measure immobility as a central PD sign, locomotion of marmosets in their individual living cages were recorded daily by infrared sensors. Daily locomotion counts decreased drastically after MPTP regimens and remained diminished for several months or more. PET scan of the brain, using [11C]PE2I as a ligand of the dopamine (DA) transporter, was performed once several months after the last MPTP regimen. The mean binding potential (BPND) in the striatum (putamen and caudate) of the MPTP-marmoset group was significantly lower than that of the MPTP-free control group (n = 5 for each group). In the MPTP-marmosets, the decrease of BPND in the striatum closely correlated with the decrease in locomotion counts (r = 0.98 in putamen and 0.91 in caudate).Conclusion/SignificanceThe present characterization of neural degeneration using non-invasive PET imaging and of behavioral manifestation in the MPTP marmoset mimics typical PD characteristics and can be useful in evaluating the phenotype of TG marmosets being developed.

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Neurobehavioral protection by single dose l-deprenyl against MPTP-induced parkinsonism in common marmosets

Abstract: The present preclinical methods using continuous recording of activity of marmosets in their living cages and autoradiography using dopamine transporter ligand might be sensitive for detecting protective actions of drugs for Parkinson's disease.

Cited by 37 publications

References 22 publications

Cross‐species comparison of behavioral neurodevelopmental milestones in the common marmoset monkey and human child

Cross‐species comparison of behavioral neurodevelopmental milestones in the common marmoset monkey and human child

Derivation of Neural Progenitors and Retinal Pigment Epithelium from Common Marmoset and Human Pluripotent Stem Cells

PET Analysis of Dopaminergic Neurodegeneration in Relation to Immobility in the MPTP-Treated Common Marmoset, a Model for Parkinson’s Disease

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