Neuroanatomy of adult strabismus: a voxel-based morphometric analysis of magnetic resonance structural scans

Chan, Suk-Tak; Tang, Kwok-wing; Lam, Kwok-cheung; Chan, L.K.; Mendola, Janine D.; Kwong, Kenneth K.

doi:10.1016/j.neuroimage.2004.02.021

Cited by 79 publications

(94 citation statements)

References 49 publications

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“…These findings may indicate a global reorganization of tissue composition throughout the brain, rather than isolated increases or decreases in regional GM volumes. This is supported by previous VBM-based studies demonstrating that both increases and decreases of GM coexist in several conditions, such as heavy marijuana use [36], adult strabismus [37], obsessive compulsive disorder [38], bipolar disorder [39], dyslexia [40], Down's syndrome [41], schizophrenia [42], and obesity [5].…”

Section: Discussionsupporting

confidence: 80%

Relationships between plasma leptin concentrations and human brain structure: A voxel-based morphometric study

Pannacciulli¹,

Le²,

Chen

et al. 2007

Neuroscience Letters

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We have previously demonstrated that obese people have reduced grey matter (GM) in several brain areas, including regions implicated in the regulation of taste (i.e., inferior frontal operculum and postcentral gyrus), reward (i.e., putamen), and behavioral processing (i.e., middle frontal gyrus), compared with their lean counterparts. It is well established that the brain may serve as a direct target for adiposity signals, one of the most important being leptin. We investigated the relationships between fasting plasma leptin concentrations and brain tissue composition in a group of 32 young adult Caucasians (12M/20F, age 32±1 y, body fat 29±1%, mean ± SE) with normal glucose tolerance by using voxel-based morphometry of magnetic resonance imaging scans. Fasting plasma leptin concentrations were positively correlated with grey matter (GM) volumes of the left cerebellum and left inferior temporal gyrus and negatively associated with GM volumes of the left inferior frontal operculum, left postcentral gyrus, and right putamen (P<0.001, uncorrected for multiple comparisons) after adjustment for sex, percent body fat, age, fasting plasma insulin concentrations (i.e., the major determinants of plasma leptin), and global GM volume (thus allowing for an assessment of regional effects only). This study showed an independent, negative correlation between fasting plasma leptin concentrations, which are increased in obesity, and the volumes of GM in brain areas where obese people have reduced GM compared to their lean counterparts. These relationships may explain some of the abnormalities in brain morphology recently found to be associated with excess body fatness.

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Section: Discussionsupporting

confidence: 80%

Relationships between plasma leptin concentrations and human brain structure: A voxel-based morphometric study

Pannacciulli¹,

Le²,

Chen

et al. 2007

Neuroscience Letters

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“…Given that changes in the periphery, i.e., loss of afferent input due to unilateral amputation of an extremity or phantom pain due to spinal cord injury (Wrigley et al, 2009) and even amblyopia (Mendola et al, 2005) and strabismus (Chan et al, 2004) may change the brain structure of individuals, one has to conclude that these changes are possibly a result of experience-dependent neuronal plasticity (Draganski and May, 2008). Our data provide evidence for activation-dependant brain plasticity in humans on a structural level (Draganski et al, 2004;Boyke et al, 2008) as the key to structural changes of the brain in chronic pain patients.…”

Section: Discussionmentioning

confidence: 99%

Brain Gray Matter Decrease in Chronic Pain Is the Consequence and Not the Cause of Pain

Rodriguez-Raecke¹,

Niemeier²,

Ihle³

et al. 2009

J. Neurosci.

466

329

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Recently, local morphologic alterations of the brain in areas ascribable to the transmission of pain were reported in patients suffering from chronic pain. Although some authors discussed these findings as damage or loss of brain gray matter, one of the key questions is whether these structural alterations in the cerebral pain-transmitting network precede or succeed the chronicity of pain. We investigated 32 patients with chronic pain due to primary hip osteoarthritis and found a characteristic gray matter decrease in patients compared with controls in the anterior cingulate cortex (ACC), right insular cortex and operculum, dorsolateral prefrontal cortex (DLPFC), amygdala, and brainstem. We then investigated a subgroup of these patients (n ϭ 10) 6 weeks and 4 months after total hip replacement surgery, monitoring whole brain structure. After surgery, all 10 patients were completely pain free and we observed a gray matter increase in the DLPFC, ACC, amygdala, and brainstem. As gray matter decrease is at least partly reversible when pain is successfully treated, we suggest that the gray matter abnormalities found in chronic pain do not reflect brain damage but rather are a reversible consequence of chronic nociceptive transmission, which normalizes when the pain is adequately treated.

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“…There is evidence for reduced grey matter in the lateral geniculate nucleus (LGN) (Barnes et al, 2010;von Noorden, Crawford, & Levacy, 1983), and the primary and extrastriate visual cortex (Chan et al, 2004;Mendola et al, 2005). Whether these structural changes are restricted to grey matter or affect the white matter is an open question, although some evidence for abnormal development of the prechiasmatic pathways (Gümüstas et al, 2013;Pineles & Demer, 2009) and optic radiations has been reported in children with amblyopia (Ming-xia et al, 2007;Song et al, 2010;Xie et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Altered white matter in early visual pathways of humans with amblyopia

et al. 2015

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Amblyopia is a visual disorder caused by poorly coordinated binocular input during development. Little is known about the impact of amblyopia on the white matter within the visual system. We studied the properties of six major visual white-matter pathways in a group of adults with amblyopia (n=10) and matched controls (n=10) using diffusion weighted imaging (DWI) and fiber tractography. While we did not find significant differences in diffusion properties in cortico-cortical pathways, patients with amblyopia exhibited increased mean diffusivity in thalamo-cortical visual pathways. These findings suggest that amblyopia may systematically alter the white matter properties of early visual pathways.

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Neuroanatomy of adult strabismus: a voxel-based morphometric analysis of magnetic resonance structural scans

Cited by 79 publications

References 49 publications

Relationships between plasma leptin concentrations and human brain structure: A voxel-based morphometric study

Relationships between plasma leptin concentrations and human brain structure: A voxel-based morphometric study

Brain Gray Matter Decrease in Chronic Pain Is the Consequence and Not the Cause of Pain

Altered white matter in early visual pathways of humans with amblyopia

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