2014
DOI: 10.1016/j.nicl.2013.10.013
|View full text |Cite|
|
Sign up to set email alerts
|

Abstract: Brain imaging in Klinefelter syndrome (47, XXY) (KS), a genetic disorder characterized by the presence of an extra X chromosome, may contribute to understanding the relationship between gene expression, brain structure, and subsequent cognitive disabilities and psychiatric disorders.We conducted the largest to date voxel-based morphometry study of 65 KS subjects and 65 controls matched for age and education and correlated these data to neuropsychological test scores. The KS patients had significantly smaller t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

6
88
2

Year Published

2014
2014
2021
2021

Publication Types

Select...
5
2

Relationship

1
6

Authors

Journals

citations
Cited by 60 publications
(96 citation statements)
references
References 65 publications
6
88
2
Order By: Relevance
“…This is consistent with prior research finding. No cognitive differences observed between KS patients treated with testosterone and those who were not (Skakkebaek et al., 2013). In further support of this, no effect of testosterone treatment on cognitive functions is seen in hypogonadal men without KS (Holland, Bandelow, & Hogervorst, 2011).…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…This is consistent with prior research finding. No cognitive differences observed between KS patients treated with testosterone and those who were not (Skakkebaek et al., 2013). In further support of this, no effect of testosterone treatment on cognitive functions is seen in hypogonadal men without KS (Holland, Bandelow, & Hogervorst, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…This research has also been registered at ClinicalTrials.gov (Clinical trial NCT00999310). Certain genetic, anatomical, and neuropsychological data from this research has been presented previously to address separate research questions (Skakkebaek et al., 2013, 2014). …”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…A recent, comprehensive study reported higher rates of anxiety and depression in men with KS (Skakkebaek et al, 2014). Corresponding MRI data revealed that men with KS had Hormonal contribution to affective psychopathologies across species 14 lower grey matter volume compared to controls matched for age and education in a variety of affective regions including the hippocampus, the insula, and the corpus striatum (Skakkebaek et al, 2014 Hypogondal syndromes in humans are also comparable to castration in male rodents, as a result of removing the endogenous source of androgens in adulthood. A higher incidence of anxiety-like behaviours was evident in male mice castrated in adulthood, compared to males undergoing sham surgery (Slack et al, 2009).…”
Section: Testosterone Deficiencymentioning
confidence: 95%
“…The reviewed literature consistently indicates higher levels of depression and anxiety across conditions with a strong, inherent hormonal component. While most studies documented the presence of psychopathology in affected individuals (Barry et al, 2011;Bruining et al, 2009;Downey et al, 1989;Fliegner et al, 2013;Halbreich et al, 2003;Mueller et al, 2010;Skakkebaek et al, 2014;Woods and Mitchell, 2005), another study found state measures to directly correlate with circulating androgens (Livadas et al, 2011). Yet another line of work supports this model by showing that testosterone administration may be beneficial for mood status in hypogonadal men when their hormonal levels are below the normal range of values but less beneficial if hormonal levels are within the normal range (Alexander et al, 1997).…”
Section: Hormonal Contribution To Affective Psychopathologies Across mentioning
confidence: 99%