Neuroanatomical Alterations in Tinnitus Assessed with Magnetic Resonance Imaging

Allan, Thomas W.; Besle, Julien; Langers, Dave R. M.; Davies, J. E.; Hall, Deborah A.; Palmer, Alan R.; Adjamian, Peyman

doi:10.3389/fnagi.2016.00221

Cited by 43 publications

(63 citation statements)

References 50 publications

(108 reference statements)

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“…None of the studies discussed sample size justification or power calculations. Nine of the studies explicitly stated their subjects’ tinnitus severity, while four mentioned which severity score they used, but did not include the actual score (Allen et al 2016, Leaver et al 2011, Leaver et al 2012, Melcher et al 2013). …”

Section: 0 Resultsmentioning

confidence: 99%

“…Three studies did not use any control groups and analyzed brain volume changes of tinnitus using only regression models (Schecklmann et al 2012, Schecklmann et al 2013, Vanneste et al 2015). Three of the studies that used controls had controls with hearing loss and with normal hearing (Allan et al 2016, Boyen et al 2013, Husain et al 2011). The other seven studies used a single control group in their VBM study (Krick et al 2015, Landgrebe et al 2009, Leaver et al, 2011, Leaver et al 2012, Mahoney et al 2011, Melcher et al 2013, Mühlau et al 2005).…”

Section: 0 Resultsmentioning

confidence: 99%

“…Four of the studies did not allow for any type of hearing loss (Landgrebe et al 2009, Melcher et al 2013, Mühlau et al 2006, Schecklmann et al 2013). An important consistency of the studies is that all but three (Allan et al 2016, Boyen et al 2013, Mahoney et al 2011) of the studies excluded patients with anatomical causes of tinnitus, such as acoustic neuroma.…”

Section: 0 Resultsmentioning

confidence: 99%

“…2015, Landgrebe et al 2009, Mahoney et al 2011, Mühlau et al 2006); three studies matching controls on age, sex, and hearing loss (Allan et al 2016, Husain et al 2011, Melcher et al 2013); and one study that did not describe how they chose their controls (Boyen et al 2013). Two studies did not mention matching their controls to patients on any variables (Leaver et al 2011, Leaver et al 2012).…”

Section: 0 Resultsmentioning

confidence: 99%

“…This process left nine studies that addressed VBM and tinnitus. Upon further review, we identified one additional article (Leaver et al, 2011) that did not appear in the search, but was cited in the VBM/tinnitus literature; reviewers also pointed us to three additional papers (Allan et al 2016, Krick et al 2015, Mahoney et al 2011). In total, 13 articles met the selection criteria of the study.…”

Section: 0 Methodologymentioning

confidence: 99%

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A methodological assessment of studies that use voxel-based morphometry to study neural changes in tinnitus patients

et al. 2017

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Background The scientific understanding of tinnitus and its etiology have transitioned from thinking of tinnitus as solely a peripheral auditory problem to an increasing awareness that cortical networks may play a critical role in tinnitus percept or bother. With this change, studies that seek to use structural brain imaging techniques to better characterize tinnitus patients have become more common. These studies include using voxel-based morphometry (VBM) to determine if there are differences in regional gray matter volume in individuals who suffer from tinnitus and those who do not. However, studies using VBM in patients with tinnitus have produced inconsistent and sometimes contradictory results. Objective This paper is a systematic review of all of the studies to date that have used VBM to study regional gray matter volume in people with tinnitus, and explores ways in which methodological differences in these studies may account for their heterogeneous results. We also aim to provide guidance on how to conduct future studies using VBM to produce more reproducible results to further our understanding of disease processes such as tinnitus. Methods Studies about tinnitus and VBM were searched for using PubMed and Embase. These returned 15 and 25 results respectively. Of these, nine met the study criteria and were included for review. An additional 5 studies were identified in the literature as pertinent to the topic at hand and were added to the review, for a total of 13 studies. Results There was significant heterogeneity among the studies in several areas, including inclusion and exclusion criteria, software programs, and statistical analysis. We were not able to find publicly shared data or code for any study. Discussion The differences in study design, software analysis, and statistical methodology make direct comparisons between the different studies difficult. Especially problematic are the differences in the inclusion and exclusion criteria of the study, and the statistical design of the studies, both of which could radically alter findings. Thus, heterogeneity has complicated efforts to explore the etiology of tinnitus using structural MRI. Conclusion There is a pressing need to standardize the use of VBM when evaluating tinnitus patients. While some heterogeneity is expected given the rapid advances in the field, more can be done to ensure that there is internal validity between studies.

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Section: 0 Resultsmentioning

confidence: 99%

Section: 0 Resultsmentioning

confidence: 99%

Section: 0 Resultsmentioning

confidence: 99%

Section: 0 Resultsmentioning

confidence: 99%

Section: 0 Methodologymentioning

confidence: 99%

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A methodological assessment of studies that use voxel-based morphometry to study neural changes in tinnitus patients

et al. 2017

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Diverse application of MRI for mouse phenotyping

2017

Birth Defects Research

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Small animal models, particularly mouse models, of human diseases are becoming an indispensable tool for biomedical research. Studies in animal models have provided important insights into the etiology of diseases and accelerated the development of therapeutic strategies. Detailed phenotypic characterization is essential, both for the development of such animal models and mechanistic studies into disease pathogenesis and testing the efficacy of experimental therapeutics. Magnetic Resonance Imaging (MRI) is a versatile and non-invasive imaging modality with excellent penetration depth, tissue coverage, and soft tissue contrast. MRI, being a multi-modal imaging modality, together with proven imaging protocols and availability of good contrast agents, is ideally suited for phenotyping mutant mouse models. Here we describe the applications of MRI for phenotyping structural birth defects involving the brain, heart, and kidney in mice. The versatility of MRI and its ease of use are well suited to meet the rapidly increasing demands for mouse phenotyping in the coming age of functional genomics.

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Outcomes at 6 months are related to brain structural and white matter microstructural reorganization in idiopathic tinnitus patients treated with sound therapy

Chen

Wang

et al. 2020

Human Brain Mapping

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This study aimed to explore brain structural and white matter microstructural reorganization in the early stage of tinnitus and identify brain alterations that contribute to its relief after 6 months of sound therapy. We studied 64 patients with idiopathic tinnitus, including 29 patients who were categorized into an effective group (EG) and 35 who were categorized into an ineffective group (IG) according to the 6‐month follow‐up improvement of the Tinnitus Handicap Inventory score, along with 63 healthy controls (HCs). All participants underwent structural and diffusion tensor imaging scanning on a 3‐T magnetic resonance system. Differences in brain gray/white matter volume and white matter microstructure were evaluated using voxel‐based morphometry analysis and tract‐based spatial statistics among the three groups. Associations between brain reorganization and the improvement of tinnitus symptoms were also investigated. Compared with EG patients, IG patients experienced a significant gray matter volume decrease in the right middle frontal gyrus (MFG)/right precentral gyrus (PreCG). Meanwhile, both EG and IG patients showed significant changes (decrease or increase) in brain white matter integrity in the auditory‐related or nonauditory‐related white matter fiber tracts compared with HCs, while EG patients showed decreased axial diffusivity in the bilateral middle cerebellar peduncle (MCP) compared with IG patients. We combined the gray matter change of the MFG/PreCG and the white matter integrity of the bilateral MCP as an imaging indicator to evaluate the patient's prognosis and screen patients before treatment; this approach reached a sensitivity of 77.1% and a specificity of 82.8%. Our study suggests that there was a close relationship between brain reorganization and tinnitus improvement. The right MFG/PreCG and bilateral MCP may be indicators that can be used to predict prognoses in patients with idiopathic tinnitus and may be used to screen patients before sound therapy. These findings may provide new useful information that can lead to a better understanding of the tinnitus mechanism.

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Neuroanatomical Alterations in Tinnitus Assessed with Magnetic Resonance Imaging

Cited by 43 publications

References 50 publications

A methodological assessment of studies that use voxel-based morphometry to study neural changes in tinnitus patients

A methodological assessment of studies that use voxel-based morphometry to study neural changes in tinnitus patients

Diverse application of MRI for mouse phenotyping

Outcomes at 6 months are related to brain structural and white matter microstructural reorganization in idiopathic tinnitus patients treated with sound therapy

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