Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis

Yousefifard, Mahmoud; Rahimi-Movaghar, Vafa; Nasirinezhad, Farinaz; Baikpour, Masoud; Safari, Saeed; Saadat, Soheil; Jafari, Ali; Asady, Hadi; Tousi, Seyed Mohammad Taghi Razavi; Hosseini, Mostafa

doi:10.1016/j.neuroscience.2016.02.034

Cited by 135 publications

(114 citation statements)

References 118 publications

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“…Recently, numerous studies have confirmed the contribution of NSCs to the recovery of nerve function following spinal cord injury 3–7 . NSCs are used to repair the damaged nervous system, either by transplantation of cells grown in vitro or by activation of endogenous stem cells.…”

Section: Introductionmentioning

confidence: 99%

Formyl peptide receptors promotes neural differentiation in mouse neural stem cells by ROS generation and regulation of PI3K-AKT signaling

Zhang

Wang

Chen

et al. 2017

Sci Rep

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This study aimed to determine whether formyl peptide receptors (FPRs) regulated the differentiation of neural stem cells (NSCs). FPRs promote the migration of NSCs both in vitro and in vivo. However, the role of FPRs during differentiation of NSCs is unknown. Analysis by Western blot showed significantly increased expression of FPR1 and FPR2 during differentiation of NSCs. The activation of FPRs promotes NSCs to differentiate into neurons with more primary neurites and branch points and longer neurites per cell. Meanwhile, this activation also inhibits the differentiation of NSC into astrocytes. This bidirectional effect can be inhibited by the FPRs-specific inhibitor. Moreover, it was found that the activation of FPRs increased the generation of reactive oxygen species (ROS) and phosphorylation of AKT in the NSCs, while N-acetylcysteine and LY294002 inhibited the FPRs-stimulated increase in ROS generation and AKT phosphorylation, and blocked the FPRs-stimulated neural differentiation into neurons. Therefore, FPRs-stimulated neural differentiation was mediated via ROS and PI3K-AKT signaling pathways. Collectively, the present findings provided a novel insight into the functional role of FPRs in neurogenesis, with important implications for its potential use as a candidate for treating brain or spinal cord injury.

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Section: Introductionmentioning

confidence: 99%

Formyl peptide receptors promotes neural differentiation in mouse neural stem cells by ROS generation and regulation of PI3K-AKT signaling

Zhang

Wang

Chen

et al. 2017

Sci Rep

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“…A partir do 25º dia, os animais do grupo CTM apresentavam resultado significativamente maior que os do grupo TP (p<0,05). Os animais dos grupos Adicionalmente, diversos estudos demonstram a capacidade de recuperação neurológica funcional de ratos submetidos à TEA, após utilização de CT, via diferentes mecanismos de ação (Oliveri et al 2014, Zhang & He 2014, Yousefifard et al 2016. Numerosos estudos têm sugerido que é mais provável que as CTM atuem por mecanismos parácrinos transitórios ao invés de sobreviverem por longo prazo e substituírem as células danificadas (Oliveri et al 2014, Han et al 2015.…”

Section: Resultsunclassified

“…, Gabriela F. Siano 2 e Eliane G. Melo secundária é desencadeada por uma série complexa de eventos celulares que induz a morte por apoptose dentro de poucas horas a vários dias após o trauma inicial (Crowe et al 1997, Springer et al 1999, Han et al 2015, Yousefifard et al 2016. Dentre os vários estímulos que promovem ativação dos fatores apoptóticos está a sobrecarga do íon cálcio (Ca 2+ ) no meio intracelular (Springer et al 1999, Oo et al 2015.…”

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“…Adicionalmente, o uso de terapia celular é uma estratégia promissora para o tratamento de doenças neurodegenerativas, seja via ação direta, por meio de sua diferenciação em neurônios que irão substituir aqueles que foram lesionados (Woodbury et al 2000, Rooney et al 2009), seja via supressão de inflamação local, ou pela estimulação da produção de citocinas, quimiocinas e fatores de crescimento (Himes et al 2006, Dasari et al 2007, Sasaki et al 2009, Osaka et al 2010, Oliveri et al 2014, os quais, supostamente, favorecem a neurogênese das células-tronco (CT) neurais endógenas e o reparo tecidual (Jaerve et al 2012, Yousefifard et al 2016.…”

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Dantrolene e células-tronco mesenquimais promovem melhora funcional em ratos Wistar com trauma espinhal agudo

et al. 2018

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RESUMO.-Objetivou-se avaliar o efeito do dantrolene (DAN) e das células-tronco mesenquimais (CTM) no trauma espinhal agudo (TEA). Sessenta ratos Wistar foram divididos nos grupos CTM, DAN + CTM, DAN, trauma e placebo (TP) e sem trauma e placebo (STP). Realizou-se laminectomia de T12 em todos os grupos, seguida de TEA contusivo ∕ compressivo, com exceção do grupo STP. This study aimed to evaluate the effects of dantrolene (DAN) and mesenchymal stem cells (MSCs) in acute spinal cord injury (SCI). Sixty Wistar rats were divided into groups MSCs, MSCs + DAN, DAN, trauma and placebo (TP) and no trauma and placebo (STP). Laminectomy was performed at T12 level in all animals, followed by a weight-drop model of SCI, except for the STP group. An hour later, the MSCs + DAN and DAN groups received 10mg/kg of DAN. After seven days, the MSCs and MSCs + DAN groups received 1x10 6 cells intravenously. Behavioral tests were performed to assess functional recovery for 28 days. Traumatized animals showed paraplegia. There was a significant improvement in groups MSCs, DAN and MSCs + DAN compared to TP (p<0.05). It was concluded that DAN and MSCs for the treatment of SCI in rats have neuroprotection effect and promote functional neurological improvement.

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“…There are a few clinical trials of cell therapy for acute or subacute SCI, with 33 or without positive outcome. 34 An acute SCI leads to obvious edema and inflammatory reaction in damaged area, and cell injections may exacerbate injury at this period; so, the spinal cord with an acute injury may not be suitable for direct cell transplantation into injured area.…”

Section: Cell Therapymentioning

confidence: 99%

Clinical therapeutic guideline for neurorestoration in spinal cord injury (Chinese version 2016)

Feng¹,

Sun²,

Chen³

et al. 2017

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Abstract:Restoring functions following spinal cord injury (SCI) was the most challenging task in clinical practice in the past. Fortunately, some effective neurorestorative methods have been exploited in acute, subacute, and chronic phase of SCI. There were no clinical neurorestorative therapeutic guidelines available before this document which can be followed by physicians to manage patients with acute, subacute, and chronic SCI. This guideline will be a helpful reference to physicians to implement their neurorestorative strategies that can help to improve the neurological functions in patients with SCI and their quality of life.

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Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis

Cited by 135 publications

References 118 publications

Formyl peptide receptors promotes neural differentiation in mouse neural stem cells by ROS generation and regulation of PI3K-AKT signaling

Formyl peptide receptors promotes neural differentiation in mouse neural stem cells by ROS generation and regulation of PI3K-AKT signaling

Dantrolene e células-tronco mesenquimais promovem melhora funcional em ratos Wistar com trauma espinhal agudo

Clinical therapeutic guideline for neurorestoration in spinal cord injury (Chinese version 2016)

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